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  • Focus Biomolecules supplier, chemical structure of 6-Formylindolo[3,2-b]carbazole | AhR endogenous agonist | CAS 172922-91-7
    6-Formylindolo(3,2-b)carbazole (172922-91-7) is a very potent (Kd = 0.07 nM) endogenous ligand for the aryl hydrocarbon receptor (AhR).1,2 References/Citations1) Rannung et al. (1987) Certain photooxidized derivatives of...

  • CH-223191 | Arylhydrocarbon receptor antagonist
    Arylhydrocarbon (AhR) receptor antagonist, IC50=30 nM.1 Blocks endogenous AhR agonist-induced differentiation of Th17 cells.2   Promotes expansion of human hematopoietic stem cells.3 Mitigates cytokine-mediated...

  • Cinnabarinic acid | Endogenous AhR ligand
    Cinnabarinic acid (606-59-7) is a novel endogenous tryptophan metabolite which acts as an aryl hydrocarbon receptor (AHR) agonist.1 It drives IL-22 production by stimulating the differentiation of human and mouse T cells...

  • DiMNF | 14756-24-2 | Structure | Supplier
    DiMNF (14756-24-2) is a selective aryl hydrocarbon receptor (AHR) modulator (SAhRM). It exhibits antiinflammatory activity including suppression of cytokine-mediated acute phase genes through dissociation of...

  • Kynurenine (L) | Endogenous AhR agonist
    Kynurenine (2922-83-0) is a tryptophan catabolite.1 Endogenous tumor-promoting ligand of the human aryl hydrocarbon receptor (AhR). Constitutively generated by human tumor cells via the action of the tryptophan...

  • Pifithrin alpha | p53 inhibitor
    Pifithrin α (63208-82-2) is a reversible inhibitor of p53-mediated transcription and p53-dependent apoptosis. Enhances survival after genotoxic stress and protects against chemotherapeutic side-effects in mice.1,2...

  • SR1 | Maintains stem cells in pluripotent state
    SR1 (1227633-49-9) extends the pluripotency of hematopoietic stem cells (IC50 = 127 nM) by antagonizing AhR signaling resulting in continued expression of CD34. Effects are easily reversed by the removal of the SR1...

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