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GSK-3787 | PPARδ antagonist

CAS:
188591-46-0
Catalog Number:
10-1001
Activity:
PPARδ antagonist
Chemical Names:
4-Chloro-N-(2-{[5-(trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide
Molecular Weight:
392.78
Molecular Formula:
C15H12ClF3N2O3S
Solubility:
Soluble in DMSO (30 mg/ml)
Physical Properties:
White solid
Purity:
98% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year for up to year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

GSK-3787 (188591-46-0) is a selective and irreversible antagonist of the peroxisome proliferator-activated receptor δ (PPARδ) – plC50 = 6.6. It covalently binds to Cys 249 in the PPARd binding site.

References:

  1. Shearer et al., (2010)  Identification and characterization of 4-chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide (GSK3787), a selective and irreversible peroxisome proliferator-activated receptor delta (PPARdelta) antagonist;  J. Med. Chem. 53  1857
  2. Palkar et al (2010) Cellular and pharmacological selectivity of the peroxisome proliferator-activated receptor-β/δ antagonist GSK3787;  Mol.Pharmacol. 78  419
GSK-3787 | PPARδ antagonist is also available in the Cellular Metabolism Library.
CAS:
188591-46-0
Catalog Number:
10-1001
Activity:
PPARδ antagonist
Chemical Names:
4-Chloro-N-(2-{[5-(trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide
Molecular Weight:
392.78
Molecular Formula:
C15H12ClF3N2O3S
Solubility:
Soluble in DMSO (30 mg/ml)
Physical Properties:
White solid
Purity:
98% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year for up to year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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