Laquinimod | Immunomodulator
NMR (Conforms)
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T0901317 (293754-55-9) is a potent high affinity liver X receptor (LXRα and β) agonist, EC50~50 nM.1 Upregulates expression of ABCA1, a reverse cholesterol transporter, resulting in
Verrucarin A (3148-09-2) is a macrocyclic trichothecene mycotoxin from Myrothecium sp. It is a potent and selective inhibitor of the steroid receptor coactivator-3 and selectively down-regulates its
KL044 (1801856-93-8) is a potent stabilizer of the circadian clock protein cryptochrome (CRY).1 It lengthened the circadian period and repressed Per2 activity in reporter assays with 10-fold more potency
N-(2-(2,4-Dimethylphenyl)-2,6-dihydro-4H-thieno[3,4-c]pyrazol-3-yl)-3,4-dimethylbenzamide
1-(4-Chlorophenyl)-N-[2,6-dihydro-2-(4-methoxyphenyl)-5,5-dioxido-4H-thieno[3,4-c]pyrazol-3-yl]cyclopentanecarboxamide
SLU-PP-332 (303760-60-3) is a pan-agonist of the estrogen receptor-related receptors (EC50’s cell-based cotransfection/reporter assay: ERRα = 98 nM, ERRß = 230 nM, ERRγ = 430 nM)
T0901317 (293754-55-9) is a potent high affinity liver X receptor (LXRα and β) agonist, EC50~50 nM.1 Upregulates expression of ABCA1, a reverse cholesterol transporter, resulting in
T0901317 (293754-55-9) is a potent high affinity liver X receptor (LXRα and β) agonist, EC50~50 nM.1 Upregulates expression of ABCA1, a reverse cholesterol transporter, resulting in
SR3335 (293753-05-6) is a selective RORα partial inverse agonist (IC50 = 480 nM) – displays no activity at RORß, RORγ, or FXR.1 It was able to suppress gluconeogenesis
SR1078 (1246525-60-9) is an agonist of the orphan nuclear receptors RORα and RORγ.1 It attenuated intrapancreatic pathological changes in mouse models of chronic pancreatitis via restoration of the circadian
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