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  • Focus Biomolecules supplier, structure of 24(S)-Hydroxycholesterol | Endogenous cholesterol metabolite | CAS 474-73-7
    24S Hydroxycholesterol (474-73-7) is an important cholesterol metabolite (cholesterol 24-hydroxylase) found in the brain.1 It is an endogenous agonist of the nuclear receptor LXR.2 It has been shown to induce cell death in...

  • Focus Biomolecules cell signaling supplier, chemical structure of Nobiletin | Attenuates metabolic syndrome | CAS 478-01-3
    Nobiletin (478-01-3) is a natural product isolated from citrus peels.  It has recently been shown to possess circadian clock amplitude-enhancing properties and was able to prevent metabolic syndrome in mice via a Clock...

  • SR0987 | RORgamma t agonist
    RORγt is a T cell specific isoform of ROR that is a key transcription factor for initiating the differentiation of Th17 and Tc17 cells. SR0987 (303126-97-8) is a RORγt agonist that drives proliferation of Th17...

  • Focus Biomolecules cell signaling reagent supplier, structure of SR-1001 | RORŒ± and RORŒ≥t  agonist | CAS 1335106-03-0
    SR1001 (1335106-03-0) is a high affinity synthetic ligand for both RORα and RORγt acting as an inverse agonist. It binds specifically to the ligand-binding domain, inducing a conformational change which leads to...