Obesity and metabolic diseases
Showing 1–12 of 53 results
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Adiponectin
AdipoRon | Adiponectin agonist
AdipoRon (924416-43-3) is a novel potent and selective adiponectin (AdipoR1 and AdipoR2) receptor agonist, Kd=1.8 and 3.1 μM respectively.1 Display...$50.00 – $200.00 Select options -
Diabetes
Amlexanox | TBK1 inhibitor / Antidiabetic
Amlexanox (68302-57-8) improves obesity-related metabolic dysfunction in mouse models.1 Increases thermogenesis and weight loss, decreases steatosi...$40.00 – $100.00 Select options -
New Products
Autogramin-2 | Autophagy blocker / GRAMD1A inhibitor
Autogramin-2 (2375541-45-8) is an inhibitor of autophagy (autophagy induced by amino acid starvation IC50 = 270 nM; Rapamycin IC50 = 140 nM) acting...$70.00 – $275.00 Select options -
New Products
Belumosudil | ROCK2 Inhibitor
Belumosudil (911417-87-3) is a selective inhibitor of Rho kinase 2 (ROCK2) – IC50’s: ROCK2 = 105 nM, ROCK1 = 24 µM in enzyme assays.1 It downregula...$45.00 – $145.00 Select options -
New Products
Bempedoic acid | ATP citrate lyase inhibitor
Bempedoic acid (738606-46-7) is an inhibitor of ATP citrate lyase (ACL) and activator of AMPK used in the treatment of hypercholesterolemia.1,2 In ...$45.00 – $125.00 Select options -
Bioactive Lipids
BMS-303141 | ATP citrate lyase (ACL) inhibitor
BMS-303141 (943963-47-8) is a potent and selective ATP citrate lyase (ACL) inhibitor, IC50=0.13 μM. Inhibits lipid biosynthesis, IC50=8 μM in HepG2...$70.00 – $280.00 Select options -
Atherosclerosis
BMS-309403 | FABP4 inhibitor
BMS-309403 (300657-03-8) is a potent (Ki <2 nM FABP4, Ki = 250 nM FABP3, Ki = 350 nM FABP5) and selective inhibitor of the fatty-acid-binding pr...$60.00 – $225.00 Select options -
Apoptosis
Cerulenin | Fatty Acid Synthase inhibitor
Cerulenin (17397-89-6) is a fatty acid synthase (FAS) inhibitor. Binds to β-keto-acyl-ACP synthase (KAS; IC50=1.5 μM), thus inhibiting protein acyl...$120.00 – $480.00 Select options -
Adrenergic
CL-316243 | ß3-adrenergic agonist / antiobesity
CL-316243 (151126-84-0) is a potent and selective β3-adrenergic receptor agonist. (EC50= 3 nM) Displays anti-obesity and anti-diabetic effects in m...$100.00 – $375.00 Select options -
Cellular Metabolism
Conduritol B epoxide | Glycosidase inhibitor
Conduritol B epoxide (6090-95-5) is a β-Glycosidase inhibitor.1,2 May be used for generation of the “Gaucher mouse”3 and the in vitro model of the ...$45.00 – $130.00 Select options -
AMPK
Cordycepin | AMPK activator
Cordycepin (73-03-0) is an adenosine analog lacking the hydroxyl at the 3’ position. Inhibits PARP1 and polyadenylation2. Displays anti-inflammator...$40.00 – $120.00 Select options -
Diabetes
DC260126 | GPR40 antagonist
DC260126 (346692-04-4) is a GPR40 receptor antagonist.1 Suppresses fatty acid-induced elevation of intracellular Ca++. Inhibits palmitic acid poten...$48.00 – $155.00 Select options
