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Obesity and Metabolic Diseases

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of AdipoRon | Adiponectin agonist | CAS 924416-43-3
    AdipoRon (924416-43-3) is a novel potent and selective adiponectin (AdipoR1 and AdipoR2) receptor agonist, Kd=1.8 and 3.1 μM respectively1. Displayed similar effects to adiponectin in muscle and liver such as activation...

  • Focus Biomolecules supplier, chemical structure of Amlexanox | TBK1 inhibitor / Antidiabetic | CAS 68302-57-8
    Amlexanox (68302-57-8) improves obesity-related metabolic dysfunction in mouse models.1 Increases thermogenesis and weight loss, decreases steatosis and improves insulin sensitivity.  Inhibits TANK-binding kinase 1...

  • Focus Biomolecules supplier, chemical structure of Cerulenin | Fatty Acid Synthase inhibitor | CAS 17397-89-6
    Cerulenin (17397-89-6) is a fatty acid synthase (FAS) inhibitor. Binds to β-keto-acyl-ACP synthase (KAS; IC50=1.5 μM), thus inhibiting protein acylation at concentrations of 45-134 μM.1 Cerulenin produces...

  • Focus Biomolecules supplier, chemical structure of CL-316243 | beta 3-adrenergic agonist / antiobesity | CAS 151126-84-0
    CL-316243 (151126-84-0) is a potent and selective β-3 adrenergic receptor agonist. (EC50= 3 nM) Displays anti-obesity and anti-diabetic effects in mice. It increases brown fat thermogenesis and metabolic rate and...

  • Focus Biomolecules cell signaling tech supplier, structure of Conduritol B epoxide | Glycosidase inhibitor | CAS 6090-95-5
    Conduritol B epoxide (6090-95-5) is a β-Glycosidase inhibitor.1,2 May be used for generation of the “Gaucher mouse”3 and the in vitro model of the Gaucher cell4. References/Citations 1) Datta and Radin...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of DC260126 | GPR40 antagonist | CAS 346692-24-4
    DC260126 (346692-04-4) is a GPR40 receptor antagonist1. Suppresses fatty acid-induced elevation of intracellular Ca++. Inhibits palmitic acid potentiated glucoseÐstimulated insulin secretion in Min6 pancreatic β...

  • Focus Biomolecules supplier, chemical structure of Fatostatin | SREBP activation inhibitor | CAS 125256-00-0
    Fatostatin (125256-00-0) blocks adipogenesis by inhibiting the activation of SREBP. Inhibits the ER-Golgi translocation of SREBPs via binding to their escort protein (SCAP). Fatostatin prevents increases in body weight,...

  • FSG67 | GPAT inhibitor
    FSG67 (1158383-34-6) is an inhibitor of Glycerol 3-Phosphate Acyltransferase (GPAT); IC50 = 24 μM.1 It was able to reduce food intake, decrease body weight and adiposity, enhance energy utilization as fatty acid...

  • Focus Biomolecules cell signaling reagent supplier, structure of Glyburide | K-ATP channel blocker | CAS 10238-21-8
    Glyburide (10238-21-8) is a second generation oral hypoglycemic agent. Acts via ATP-dependent K+ channel (Kir6, KATP) block.1 Inhibits Kir6 currents in the pancreas, causing an increase in intracellular Ca2+ and insulin...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of GSK-137647 | GPR120 agonist | CAS 349085-82-1
    GSK-137647 (349085-82-1) is a potent and selective agonist at free fatty acid receptor 4 (FFA4), also known as GPR120. pEC50s= 6.3, 6.2 and 6.1 for human, mouse and rat receptor respectively1. GSK-137647 enhances...

  • Focus Biomolecules cell signaling reagent supplier, structure of GSK-3787 | PPAR delta antagonist | CAS 188591-46-0
    GSK-3787 (188591-46-0) is a selective and irreversible antagonist of the peroxisome proliferator-activated receptor delta (PPARδ) plC50 = 6.6. It covalently binds to Cys 249 in the PPARδ binding site...

  • GE-501516 | 317318-70-0 | Structure | Supplier
    GW-501516 (317318-70-0) is a potent and selective PPARδ (NR1C2) agonist, EC50=1.2 nM and 1000-fold selective over other PPAR subtypes.1  Induces apolipoprotein A1-mediated cholesterol efflux in vitro.1 Improves...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of GW-9508 | GPR40 agonist | CAS 885101-89-3
    GW9508 (885101-89-3) is a selective agonist at the free fatty acid receptor, FFA1/4, (GPR40 and GPR120).1 Displays anti-allodynic and anti-hyperalgesic effects in mouse inflammatory and neuropathic pain models.2 Inhibits...

  • Isofagomine tartrate | Glucocerebrosidase activator and chaperone
    Isofagomine tartrate (957230-65-8) is a competitive inhibitor of human lysosomal β-glucosidase, IC50 = 0.06 μM.1 Increases the activity of N370S mutant acid β-glucosidase (GlcCerase) in Gaucher fibroblasts.2...

  • Miglitol | beta-glucosidase inhibitor / antidiabetic
    Miglitol (72432-03-2) is an α-glucosidase inhibitor which induces an enhanced and prolonged release of glucagon-like peptide-1, regulating appetite and stabilizing body weight in humans1. Miglitol displays...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of ML-SA1 | TRPML activator | CAS 332382-54-4
    ML-SA1 (332382-54-4) is a TRPML 1,2 and 3 channel activator.1 Does not activate TRPM2, TRPV2, TRPV3, TRPC6 or TRPA1 channels.2 ML-SA1 robustly activates whole cell TRPML1-4A and whole-endolysosome TRPML1 and is...

  • N-Oleoylphenylalanine | Structure | Supplier
    N-Oleoylphenylalanine is an endogenous lipoamino acid produced via the action of a secreted enzyme PM20D1 produced by adipocytes. N-Oleoylphenylalanine binds directly to mitochondria and functions as an endogenous uncoupler...

  • Nobiletin | Attenuates metabolic syndrome
    Nobiletin (478-01-3) is a natural product isolated from citrus peels.  It has recently been shown to possess circadian clock amplitude-enhancing properties and was able to prevent metabolic syndrome in mice via a Clock...

  • Obeticholic Acid | FXR agonist
    Obeticholic acid (459789-99-2) is a novel cholic acid analog which acts as a potent and selective FXR agonist (EC50= 99 nM). Displays anticholeretic activity in a rat model of cholestasis.1 Promotes adipocyte differentiation...

  • Oleoylethanolamide | GPR119 agonist: stimulates lipolysis
    Endogenous anandamide-like lipid acting as a PPARα agonist but does not bind to cannabinoid receptors.1 Biosynthesis via the action of NAPE-PLD on N-acylphosphatidylethanolamine.2 Agonist at GPR1193 and has been...

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