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Metabolic syndrome

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of AdipoRon | Adiponectin agonist | CAS 924416-43-3
    AdipoRon (924416-43-3) is a novel potent and selective adiponectin (AdipoR1 and AdipoR2) receptor agonist, Kd=1.8 and 3.1 μM respectively1. Displayed similar effects to adiponectin in muscle and liver such as activation...

  • Focus Biomolecules supplier, chemical structure of Amlexanox | TBK1 inhibitor / Antidiabetic | CAS 68302-57-8
    Amlexanox (68302-57-8) improves obesity-related metabolic dysfunction in mouse models.1 Increases thermogenesis and weight loss, decreases steatosis and improves insulin sensitivity.  Inhibits TANK-binding kinase 1...

  • Focus Biomolecules supplier, chemical structure of CL-316243 | beta 3-adrenergic agonist / antiobesity | CAS 151126-84-0
    CL-316243 (151126-84-0) is a potent and selective β-3 adrenergic receptor agonist. (EC50= 3 nM) Displays anti-obesity and anti-diabetic effects in mice. It increases brown fat thermogenesis and metabolic rate and...

  • FSG67 | GPAT inhibitor
    FSG67 (1158383-34-6) is an inhibitor of Glycerol 3-Phosphate Acyltransferase (GPAT); IC50 = 24 μM.1 It was able to reduce food intake, decrease body weight and adiposity, enhance energy utilization as fatty acid...

  • Focus Biomolecules cell signaling reagent supplier, structure of Glyburide | K-ATP channel blocker | CAS 10238-21-8
    Glyburide (10238-21-8) is a second generation oral hypoglycemic agent. Acts via ATP-dependent K+ channel (Kir6, KATP) block.1 Inhibits Kir6 currents in the pancreas, causing an increase in intracellular Ca2+ and insulin...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of GSK-137647 | GPR120 agonist | CAS 349085-82-1
    GSK-137647 (349085-82-1) is a potent and selective agonist at free fatty acid receptor 4 (FFA4), also known as GPR120. pEC50s= 6.3, 6.2 and 6.1 for human, mouse and rat receptor respectively1. GSK-137647 enhances...

  • Focus Biomolecules cell signaling reagent supplier, structure of GSK-3787 | PPAR delta antagonist | CAS 188591-46-0
    GSK-3787 (188591-46-0) is a selective and irreversible antagonist of the peroxisome proliferator-activated receptor delta (PPARδ) plC50 = 6.6. It covalently binds to Cys 249 in the PPARδ binding site...

  • GE-501516 | 317318-70-0 | Structure | Supplier
    GW-501516 (317318-70-0) is a potent and selective PPARδ (NR1C2) agonist, EC50=1.2 nM and 1000-fold selective over other PPAR subtypes.1  Induces apolipoprotein A1-mediated cholesterol efflux in vitro.1 Improves...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of GW-9508 | GPR40 agonist | CAS 885101-89-3
    GW9508 (885101-89-3) is a selective agonist at the free fatty acid receptor, FFA1/4, (GPR40 and GPR120).1 Displays anti-allodynic and anti-hyperalgesic effects in mouse inflammatory and neuropathic pain models.2 Inhibits...

  • Miglitol | beta-glucosidase inhibitor / antidiabetic
    Miglitol (72432-03-2) is an α-glucosidase inhibitor which induces an enhanced and prolonged release of glucagon-like peptide-1, regulating appetite and stabilizing body weight in humans1. Miglitol displays...

  • N-Oleoylphenylalanine | Structure | Supplier
    N-Oleoylphenylalanine is an endogenous lipoamino acid produced via the action of a secreted enzyme PM20D1 produced by adipocytes. N-Oleoylphenylalanine binds directly to mitochondria and functions as an endogenous uncoupler...

  • Nobiletin | Attenuates metabolic syndrome
    Nobiletin (478-01-3) is a natural product isolated from citrus peels.  It has recently been shown to possess circadian clock amplitude-enhancing properties and was able to prevent metabolic syndrome in mice via a Clock...

  • Obeticholic Acid | FXR agonist
    Obeticholic acid (459789-99-2) is a novel cholic acid analog which acts as a potent and selective FXR agonist (EC50= 99 nM). Displays anticholeretic activity in a rat model of cholestasis.1 Promotes adipocyte differentiation...

  • Oltipraz | Nrf2 activator
    Oltipraz (64224-21-1) upregulates the transcription factor NRF2 and prevents insulin resistance and obesity induced by high fat diet in C57BL/6J mice1. Attenuates the progression of fibrosis in a rat model of nonalcoholic...

  • Orlistat | DAG Lipase-alpha inhibitor
    Orlistat (96829-58-2) is a lipase inhibitor which blocks the biosynthesis of 2-AG by inhibition of DAG lipase-α1. Inhibits pancreatic lipase and other lipases but not PLA22. Inhibits fatty acid synthase and displays...

  • Punicalagin | Anti inflammatory
    Punicalagin (65995-63-3) is a polyphenolic compound isolated from pomegranates possessing antioxidant, anti-inflammatory, and antitumorigenic properties.1,2 It has been shown to reduce high glucose-induced neural tube...

  • Roflumilast | PDE4 inhibitor
    Roflumilast (162401-32-3) is a potent and selective phosphodiesterase (PDE4) inhibitor, IC50=0.7, 0.9, 0.7, 0.2 nM for PDE4A1, PDE4A4, PDE4B1 and PDE4B2 respectively.1 Clinically useful agent for treatment of COPD...

  • Focus Biomolecules cell signaling reagent supplier, structure of Rosiglitazone maleate | PPARŒ≥ agonist | CAS 155141-29-0
    Rosiglitazone (155141-29-0) is a prototypical TZD antidiabetic agent. Potent and selective PPARg agonist (Kd=43 nM).1,2  Clinically useful antihyperglycemc agent.3  Induces a brown fat gene program in subcutaneous...

  • Focus Biomolecules supplier, chemical structure of SR-9009 | RevErb alpha & beta agonist | CAS 1379686-30-2
    SR-9009 (1379686-30-2) is an agonist at nuclear receptor Rev-ErbA1. Greatly diminishes VILI-induced lung edema, inflammatory cell infiltration and TNFα production in a rat lung injury model2. SR-9009 suppresses...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Teprenone | HSP70 inducer | CAS 6809-52-5
    Teprenone (6809-52-5) induces expression of HSP70 after various types of stimuli.1,2 Protects against visceral adipocity and insulin resistance in high fat fed mice.3 Teprenone displays protective effects via enhanced...

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