Mirabegron | beta-3 Adrenergic agonist
Mirabegron (223673-61-8) is a potent (EC50 = 22.4 nM CHO cells expressing human ß3-ARs) beta-3 adrenergic receptor (ß3-AR) agonist with high selectivity over the beta-1 and
Obesity and metabolic diseases
Obesity and other metabolic disorders (such as fatty liver disease) are closely linked to diabetes, which in turn is tightly associated with glucose and fatty acid metabolism, circadian clock, mitochondrial function, inflammation, and many others. Focus Biomolecules offers many inhibitors and other modulators of the pathways involved in these processes.
Metabolic syndrome
UNC7467 | IP6K inhibitor
UNC7467 (2922283-43-8) is a potent inhibitor of inositol hexakisphosphate kinase (IP6K) – the isoform IP3K1 regulates metabolism, promotes insulin secretion from ß cells, attenuates certain aspects
SLU-PP-332 | ERR pan-agonist/Exercise mimetic
SLU-PP-332 (303760-60-3) is a pan-agonist of the estrogen receptor-related receptors (EC50’s cell-based cotransfection/reporter assay: ERRα = 98 nM, ERRß = 230 nM, ERRγ = 430 nM)
NASH/NAFLD
BI01383298 | Citrate transporter inhibitor
BI01383298 (2227549-00-8) is a potent, non-competitive, irreversible inhibitor of the human Na+-coupled citrate transporter (NaCT/SLC13A5/mINDY).1,2 IC50 = 49 nM in the presence of Li+ with preincubation
GSK620 | BD2 selective BET inhibitor
GSK620 (2088410-46-0) is a BET inhibitor 220-fold more selective for BD2 over BD1 (pIC50 BD2 = 7.1; BD1 = 4.8).1 It ameliorated collagen-induced arthritis in a rat model
DT-109 | Induces glutathione biosynthesis
CAS:
14857-82-0
Catalog Number:
10-5732
Activity:
Induces glutathione biosynthesis
Chemical Names:
Glycyl-glycyl-L-leucine; Gly-Gly-Leu-OH
Molecular Weight:
245.28
Molecular Formula:
C10H19N3O4
Solubility:
Soluble in DMSO (25 mg/ml with warming); Water (25 mg/ml)
Physical Properties:
White solid
Purity:
>98% TLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Other metabolic diseases
Migalastat HCl | Galactosidase inhibitor/Pharmacological chaperone
Migalastat (75172-81-5) is a potent, selective, and orally available inhibitor of α-galactosidase A (IC50= 40 nM).1 It binds to mutant misfolded α-GalA shifting the folding behavior
KY-226 | PTP1B inhibitor
CAS:
1621673-53-7
Catalog Number:
10-4004
Activity:
PTP1B Inhibitor
Chemical Name:
4-(Biphenyl-4-ylmethylsulfanylmethyl)-N-(hexane-1-sulfonyl)benzoylamide
Molecular Weight:
481.67
Molecular Formula:
C27H31NO3S2
Solubility:
Soluble in DMSO (>25 mg/ml).
Physical Properties:
Off-white solid
Purity:
>98% by TLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT
Miglustat HCl | Alpha-glucosidase inhibitor
CAS:
210110-90-0
Catalog Number:
10-2413
Activity:
Alpha-glucosidase inhibitor
Chemical Name:
N-Butyldeoxynojirimycin HCl
Alternate Names:
NB-DNJ
Molecular Weight:
255.74
Molecular Formula:
C10H21NO4 • HCL
Solubility:
Soluble in DMSO (up to 20 mg/ml) or in Water (up to 20 mg/ml)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.
Shipping Code:
RT
