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BiochemicalTargets

Nitric oxide and other gaseous mediators

Nitric oxide (NO), carbon monoxide (CO), hydrogen sulfide (H2S), and other gases play important roles in vascular tone, innate immunity, inflammation, and other processes. As these gases are difficult to use in a research setting, many types of small molecules have been created that act as donors of the required gases under physiological conditions.

H2S

AP39 | Mitochondrial-targeted hydrogen sulfide donor

CAS:
1429173-57-8
Catalog Number:
10-3916
Activity:
Mitochondrial targeted hydrogen sulfide donor
Chemical Names:
(10-Oxo-10-(4-(3-thioxo-3H-1,2-dithiol-5-yl)phenoxy)decyl)triphenylphosphonium bromide
Molecular Weight:
721.77
Molecular Formula:
C37H38BrO2PS3
Solubility:
Soluble in DMSO (at least 35 mg/ml)
Physical Properties:
Orange solid
Purity:
>98% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. Hygroscopic! Protect from moisture and air.
Shipping Code:
RT

GYY4137 | Hydrogen sulfide donor

CAS:
106740-09-4
Catalog Number:
10-4507
Activity:
Hydrogen sulfide donor
Chemical Names:
Morpholine (4-methoxyphenyl)(morpholino)phosphinodithioate
Molecular Weight:
376.47
Molecular Formula:
C15H25N2O3PS2
Solubility:
Soluble in DMSO (>25 mg/ml); Water (25 mg/ml)
Physical Properties:
White solid
Purity:
99% NMR
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Make solutions fresh daily – GYY4137 starts to react immediately with water.
Shipping Code:
RT

Propargylglycine | H2S synthase inhibitor

CAS:
64165-64-6
Catalog Number:
10-1366
Activity:
H2S synthase inhibitor
Chemical Name:
2-Amino-4-pentynoic acid
Molecular Weight:
113.12
Molecular Formula:
C5H7NO2
Solubility:
Soluble in DMSO (up to 10 mg/ml) or in Water (up tp 10 mg/ml).
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
Shipping Code:
RT

NO donors

DEA NONOate | NO Donor

CAS:
372965-00-9
Catalog Number:
10-4547
Activity:
NO Donor
Chemical Name:
2-(N,N-Diethylamino)-diazenolate-2-oxide diethylammonium salt
Molecular Weight:
206.29
Molecular Formula:
C4H10N3O2 • C4H12N
Solubility:
Soluble in Water or Ethanol
Physical Properties:
Off-white solid
Purity:
97% by NMR
(1H-NMR)
Storage Temperature:
-80°C
Stability:
Stable for 1 year from date of purchase s supplied. Protect from exposure to air or moisture. Solutions are not stable and must be prepared immediately before use. See the product description for information on half-life in solution.
Shipping Code:
Blue Ice

Spermine NONOate | NO Donor

CAS:
136587-13-8
Catalog Number:
10-4549
Activity:
NO Donor
Chemical Name:
1-{N-[3-Aminopropyl]-N-[4-(3-aminopropylammonio)butyl]-amino}-diazen-1-ium-1,2-diolate
Molecular Weight:
262.35
Molecular Formula:
C10H26N6O2
Solubility:
Soluble in Water or Ethanol
Physical Properties:
Off-white solid
Purity:
97% by (1H-NMR)
Storage Temperature:
-80°C
Stability:
Stable for 1 year from date of purchase as supplied. Protect from exposure to air or moisture. Buffer solutions are not stable and must be prepared immediately before use.
Shipping Code:
Blue Ice

PAPA NONOate | NO Donor

CAS:
146672-58-4
Catalog Number:
10-4548
Activity:
NO Donor
Chemical Name:
N-[3-Aminopropyl(propyl)amino]-N-hydroxynitrous amide
Molecular Weight:
176.22
Molecular Formula:
C6H16N4O2
Solubility:
Soluble in Water or Ethanol.
Physical Properties:
Off-white solid
Purity:
97% by (1H-NMR)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Protect from exposure to air or moisture. Solutions are not stable and must be prepared immediately before use.
Shipping Code:
Blue Ice

NOS

1400W | iNOS inhibitor

CAS:
214358-33-5
Catalog Number:
10-4501
Activity:
iNOS inhibitor
Chemical Name:
N-(3-Aminomethyl)benzyl)acetamidine dihydrochloride
Molecular Weight:
250.17
Molecular Formula:
C10H15N3 2HCl
Solubility:
Soluble in Water (up to 25 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year as supplied. Solutions are not stable. Solutions must be prepared fresh and used within one working day.
Shipping Code:
RT

TRIM | Nitric oxide synthase inhibitor

CAS:
25371-96-4
Catalog Number:
10-2699
Activity:
Nitric oxide synthase inhibitor
Chemical Name:
1-(2-Trifluoromethylphenyl)imidazole
Molecular Weight:
212.18
Molecular Formula:
C107F3N2
Solubility:
Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to 20 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT (des.)
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT

Peroxynitrite

SIN-1 | Peroxynitrite Donor

CAS:
16142-27-1
Catalog Number:
10-1547
Activity:
Peroxynitrite donor
Chemical Name:
Amino-3-morpholinyl-1,2,3-oxadiazolium chloride
Alternate Name:
3-Morpholinylsydnonimine chloride
Molecular Weight:
206.63
Molecular Formula:
C6H11ClN4O2
Solubility:
Soluble in DMSO (up to 35 mg/ml) or in Water (up to 65 mg/ml)
Physical Properties:
White solid
Purity:
98%
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions must be prepared fresh and cannot be stored.
Shipping Code:
RT

Trolox | Antioxidant

CAS:
53188-07-1
Catalog Number:
10-2393
Activity:
Antioxidant
Chemical Name:
6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid
Molecular Weight:
250.3
Molecular Formula:
C14H18O4
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml). Also soluble in Water at alkalinepH.
Physical Properties:
Off-white solid
Purity:
97% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Shipping Code:
RT

Ebselen | Glutathione peroxidase mimic

CAS:
60940-34-3
Catalog Number:
10-2288
Activity:
Glutathione peroxidase mimic
Alternate Names:
PZ-51
Chemical Name:
2-Phenyl-1,2-benzisoselenazol-3(2H)-one
Molecular Weight:
274.18
Molecular Formula:
C13H9NOSe
Solubility:
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 10 mg/ml with warming).
Physical Properties:
Light yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT