Pain
Bradykinin receptor Cannabinoid COX GABA Ion channels Nitric oxide NMDA receptors Opioid receptors Other metabolic diseases Prostanoid receptors Tachykinin receptor Other Pain
Showing 1–12 of 39 results
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Ion channels
2-APB | TRP activator
2-APB (524-95-8) is an IP3 receptor antagonist (IC50=42 μM).1 Inhibits store-operated Ca2+ channels at high concentrations (50 μM) but stimulates a...$25.00 – $50.00 Select options -
Ion channels
A-803467 | NaV1.8 blocker
A-803467 (944261-79-4) is a potent, selective inhibitor of the TTX-resistant voltage-gated sodium channel Nav1.8. Nav1.8 is preferentially expresse...$67.00 – $268.00 Select options -
Ion channels
A-967079 | TRPA1 blocker
A-967079 (1170613-55-4) is a TRPA1 antagonist. Active in rat models.1 Cell permeable References/Citations 1) McGaraughty et al. (2010), TRPA1 m...$78.00 – $312.00 Select options -
New Products
ABX-1431 | MAGL inhibitor
ABX-1431 is potent (IC50 = 14 nM in vitro, 2.2 nM in human PC3 cells) and very selective (>100-fold over hABHD6, >200-fold over hPLA2G7) inhi...$60.00 – $235.00 Select options -
Cannabinoid
AM-404 | Anandamide transport inhibitor
AM-404 (198022-70-7) inhibits anandamide transport (IC50 = 1 μM) without inhibiting anandamide amidase or activating cannabinoid receptors.1,2 Vani...$40.00 – $160.00 Select options -
Antioxidants
Ambroxol HCl | Free radical scavenger
Ambroxol HCl (18683-91-5) is a radical scavenger with anti-inflammatory activity. Blocks the generation of reactive oxygen species by bronchoalveol...$50.00 – $100.00 Select options -
Bioactive Lipids
Anandamide | Endogenous cannabinoid
Anandamide (94421-68-8) is an endogenous cannabinoid receptor agonist.1-3 Ki=89 nM for CB1 and 371 nM for CB2 receptors. References/Citations 1...$35.00 – $120.00 Select options -
Ion channels
AP-18 | TRPA1 blocker
AP-18 (55224-94-7) is a TRPA1 channel blocker IC50=3.1-4.5 μM in various cell lines. Reduces cinnamaldehyde-induced nociception in vivo and blocks ...$70.00 – $280.00 Select options -
Ion channels
BCTC | TRPV1 blocker
BCTC (393514-24-4) is a vanilloid receptor I (TRPV1) antagonist, IC50 = 35 nM for capsaicin-induced and 6 nM for acid-induced TRPV1 activation. Dis...$70.00 – $280.00 Select options -
Addiction
BD1047 dihydrobromide | Selective sigma-1 antagonist
BD1047 (138356-21-5) is a potent and selective sigma-1 antagonist (IC50’s: σ1 = 0.93nM, σ2 = 47nM) .1 Pretreatment of mice with BD1047 reduced con...$45.00 – $185.00 Select options -
Addiction
BD1063 dihydrochloride | Selective sigma-1 antagonist
BD1063 (206996-13-6) is potent and selective sigma-1 antagonist (IC50’s: σ1 = 9nM, σ2 = 449nM).1 BD1063 abolished mechanical and thermal hyperalges...$50.00 – $195.00 Select options -
Cancer
Celecoxib | COX II inhibitor
Celecoxib (169590-42-5) is a selective inhibitor of cyclooxygenase-2 (COX-2) IC50 = 15 and 0.04 μM for COX-1 and COX-2 respectively.1 Potent and cl...$35.00 – $150.00 Select options
