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Pain

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of A-803467 | NaV1.8 blocker | CAS 944261-79-4
    A-803467 | NaV1.8 blocker
    $67.00
    A-803467 (944261-79-4) is a potent, selective inhibitor of the TTX-resistant voltage-gated sodium channel Nav1.8. Nav1.8 is preferentially expressed in sensory neurons, and inhibition attenuates both inflammatory and...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of A-967079 | TRPA1 blocker | CAS 1170613-55-4
    A-967079 | TRPA1 blocker
    $78.00
    A-967079 (1170613-55-4) is a TRPA1 antagonist. Active in rat models.1 Cell permeable References/Citations1) McGaraughty et al. (2010), TRPA1 modulation of spontaneous and mechanically evoked firing of spinal neurons in...

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  • Focus Biomolecules supplier, chemical structure of AM-404 | Anandamide transport inhibitor | CAS 198022-70-7
    AM-404 | Anandamide transport inhibitor
    $40.00
    AM-404 (198022-70-7) inhibits anandamide transport (IC50 = 1 μM) without inhibiting anandamide amidase or activating cannabinoid receptors.1,2 Vanilloid receptors are activated by AM-404.3 Active in vivo...

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  • Focus Biomolecules cell signaling tech supplier, chemical structure Ambroxol HCl | Free radical scavenger | CAS 18683-91-5
    Ambroxol HCl | Free radical scavenger
    $50.00
    Ambroxol HCl (18683-91-5) is a radical scavenger with anti-inflammatory activity. Blocks the generation of reactive oxygen species by bronchoalveolar lavage cells, inhibits doxorubicin-induced lipid peroxidation (70 mg/kg in...

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  • Focus Biomolecules supplier, chemical structure of Anandamide | Endogenous cannabinoid | CAS 94421-68-8
    Anandamide | Endogenous cannabinoid
    $35.00
    Anandamide (94421-68-8) is an endogenous cannabinoid receptor agonist.1-3 Ki=89 nM for CB1 and 371 nM for CB2 receptors. References/Citations1) Devane et al. (1992), Isolation and structure of a brain constituent that binds...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of AP-18 | TRPA1 blocker | CAS 552244-94-7
    AP-18 | TRPA1 blocker
    $70.00
    AP-18 (55224-94-7) is a selective TRPA1 (transient receptor potential A1) channel blocker (IC50 = 3.1 and 4.5 μM at human and mouse TRPA1 respectively). References/Citations1) Petrus et al. (2007) A role of TRPA1 in...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of BCTC | TRPV1 blocker | CAS 393514-24-4
    BCTC | TRPV1 blocker
    $70.00
    BCTC (393514-24-4) is a vanilloid receptor I (TRPV1) antagonist, IC50 = 35 nM for capsaicin-induced and 6 nM for acid-induced TRPV1 activation. Displays analgesic activity in rat models of neuropathic pain. BCTC is orally...

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  • BD1047 dihydrobromide | Selective sigma-2 antagonist
    BD1047 dihydrobromide | Selective sigma-2 antagonist
    $50.00
    BD1047 (138356-21-5) is a potent and selective sigma-1 antagonist (IC50’s:  σ1 = 0.93nM, σ2 = 47nM). .1 Pretreatment of mice with BD1047 reduced convulsions, lethality, and locomotor activity induced...

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  • BD1063 dihydrochloride | Selective sigma-1 antagonist
    BD1063 dihydrochloride | Selective sigma-1 antagonist
    $50.00
    BD1063 (206996-13-6) is potent and selective sigma-1 antagonist (IC50’s: σ1 = 9nM, σ2 = 449nM).1 BD1063 abolished mechanical and thermal hyperalgesia in mice with carrageenan-induced acute inflammation by...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Capsaicin (natural) | TRPV1 agonist | CAS 404-86-4
    Capsaicin (natural) | TRPV1 agonist
    $80.00
    Capsaicin (404-86-4) is a vanilloid agonist known to activate the transient receptor potential channel vanilloid subfamily member 1 (TRPV1)1,2 and to possess analgesic3, anti-inflammatory4 and hypolocomotor effects5. SEVERE...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Celecoxib | COX II inhibitor | CAS 169590-42-5
    Celecoxib | COX II inhibitor
    $35.00
    Celecoxib (169590-42-5) is a selective inhibitor of cyclooxygenase-2 (COX-2) IC50 = 15 and 0.04 μM for COX-1 and COX-2 respectively.1 Potent and clinically useful antiinflammatory agent.2 Cancer chemopreventive...

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  • Flupirtine maleate | K+ channel activator
    Flupirtine maleate | K+ channel activator
    $55.00
    flupirtine maleate (75507-68-5) activates KV7 potassium channels1, indirectly antagonizes NMDA receptors and modulates GABAA receptors2. Displays neuroprotective actions in a model of cerebral ischemia in mice and reduces...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure Gabapentin | Neuropathic pain drug | CAS 60142-96-3
    Gabapentin | Neuropathic pain drug
    $40.00
    Gabapentin (60142-96-3) is an approved drug for treatment of various types of neuropathic pain and some forms of epilepsy.  The mechanism of action of gabapentin is not well understood. Despite being a structural mimic...

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  • Grapiprant | EP4 Receptor antagonist
    Grapiprant | EP4 Receptor antagonist
    $85.00
    Grapiprant (415903-37-6) is a potent (Ki = 13 nM for human and 20 nM for rat) and selective prostaglandin EP4 receptor antagonist.1 It produces antihyperalgesic effects in animal models of pain, and has significant...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of HC-030031 | TRPA1 blocker | CAS 349085-38-7
    HC-030031 | TRPA1 blocker
    $50.00
    HC-030031 (349085-38-7) inhibits TRPA1 channel. References/Citations1) McNamara et al. (2007), TRPA1 mediates formalin-induced pain; Proc. Natl. Acad. Sci., 104...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of HC-067047 | TRPV4 blocker | CAS 883031-03-6
    HC-067047 | TRPV4 blocker
    $58.00
    HC-067047 (883031-03-6) is a potent reversible and selective TRPV4 antagonist. Active at mouse, human and rat TRPV4, IC50 = 17, 48 and 133 nM respectively. Also inhibits the endogenous TRPV4-mediated response to 4α-PDH...

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  • Focus Biomolecules cell signaling supplier, chemical structure of Ibudilast | Neuroinflammation inhibitor | CAS 50847-11-5
    Ibudilast | Neuroinflammation inhibitor
    $40.00
    Ibudilast (CAS 50847-11-5) is a phosphodiesterase inhibitor with some selectivity for PDE4 and 5. (IC50s= 53, 35, 48, 12 and 10 μM for PDE 1a, 2, 3, 4 and 5 respectively1). Acts as a cerebral vasodilator by selectively...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Icilin | TRPM8 inhibitor | CAS 36945-98-9
    Icilin | TRPM8 inhibitor
    $65.00
    Icilin (36945-98-9) is an agonist of cold-sensitive TRP channels with 2.5-fold greater efficacy and 200-fold greater potency than menthol (EC50 = 0.36 μM for CRM1, rat orthologue of TRPM8).1 Agonist at TRPM8 (EC50 = 0.2...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of JNJ-1661010 | FAAH inhibitor | CAS 681136-29-8
    JNJ-1661010 | FAAH inhibitor
    $80.00
    JNJ-1661010 (681136-29-8) is a potent and selective FAAH inhibitor. Initially forms a covalent adduct with FAAH but is slowly released, IC50 = 12 nM. 100-fold selectivity for FAAH-1 over FAAH-2. Cell permeable and active in...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure JZL-184 | MAG lipase inhibitor | CAS 1101854-58-3
    JZL-184 | MAG lipase inhibitor
    $62.00
    JZL-184 (1101854-58-3) inhibits MAG lipase (IC50=8 nM) selectively over FAAH. Irreversible. Cell permeable. References/Citations1) Long et al. (2009), Selective blockade of 2-arachidonoylglycerol hydrolysis produces...

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