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PDGF

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  • Focus Biomolecules cell signaling reagent supplier, structure of AG-1296 | PDGFR kinase inhibitor | CAS 146535-11-7
    $60.00
    AG-1296 (146535-11-7) is a potent inhibitor of PDGF receptor kinase (IC50 = 1 μM), c-kit and FGF kinase. Induces apoptosis in H526, small-cell lung cancer cells. References/Citations1) Kovalenko et al. (1997),...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of DMPQ 2HCl | PDGFR inhibitor | CAS 137206-97-4
    $62.00
    DMPQ 2HCl (137206-97-4) is a potent and selective inhibitor of PDGFRβ, IC50=80 nM. Greater than 100-fold more selective compared to EGFR, erB2, p56, PKA and PKC. Cell permeable. References/Citations1) Dolle et al...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Dovitinib | Kinase inhibitor | CAS 405169-16-6
    $75.00
    Dovitinib (405169-16-6) is a potent kinase inhibitor. Inhibits FLT3 (IC50 = 1 nM), c-KIT (IC50 = 2 nM), FGFR (IC50 = 8 nM), VEGFR1/2/3 (IC50 = 10 nM), PDGFRβ (IC50 = 27 nM), and CSF-1R (IC50 = 36 nM).1 Active in cell...

  • Focus Biomolecules cell signaling reagent supplier, structure of SU-4312 | VEGFR / PDGFR kinase inhibitor | CAS 5813-07-7
    $70.00
    SU-4312 (5812-07-7) is a potent selective inhibitor of VEGFR kinase (also known as Flk-1 and KDR). Inhibition of the activated kinase (IC50 = 0.4 μM) is 100-fold less than inhibition of the unactivated kinase (IC50 = 0.04...

  • Focus Biomolecules cell signaling reagent supplier, Sunitinib malate | VEGFR, PDGFR kinase inhibitor | CAS 341031-54-7
    $50.00
    Sunitinib malate (341031-54-7) is a potent inhibitor of multiple receptor tyrosine kinases including VEGFR, PDGFRβ and Kit (Ki = 2-17 nM)1. Also inhibits cFMS (IC50=7 nM)2 and FLT33. Potent inhibitor of angiogenesis4...

  • Focus Biomolecules, Tyrphostin 9 structure | PDGFR kinase inhibitor & Oxidative phosphorylation inhibitor | CAS 10537-47-0
    $30.00
    Tyrphostin 9 (10537-47-0) inhibits PDGF receptor tyrosine kinase (IC50 = 1.2 μM)1 and is a potent (10 nM) inhibitor of oxidative phosphorylation2. Inhibits cell growth by disrupting mitochondria3. Tyrphostin 9 perturbs...

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