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Phosphatases

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  • Focus Biomolecules reagent supplier, chemical structure of (+/-) RK-682 | Tyrosine phosphatase inhibitor | CAS 150627-37-5
    $75.00
    RK-682 (150627-37-5) is a protein tyrosine phosphatase inhibitor (IC50's = 54 7mu;M for CD45, 2.0 μM for VHR; did not inhibit cdc25B) originally isolated from the fermentation of Streptomyces sp. 88-682.1 Inhibits cell...

  • Focus Biomolecules supplier, chemical structure of Ascomycin | FKBP ligand immunosuppressant | CAS 11011-38-4
    $35.00
    Ascomycin (11011-38-4) is an analog of FK-506 (Cat.# 10-1103). Potent immunosuppressant1. Binds to FKBP122 and inhibits calcineurin and NFAT. Ascomycin displays antiinflammatory effects in skin diseases3. Cell permeable and...

  • Focus Biomolecules, chemical structure of Bromotetramisole, L(-) oxalate | Alkaline phosphatase inhibitor | CAS 62284-79-1
    $48.00
    Bromotetramisole oxalate (62284-79-1) is a potent alkaline phosphatase inhibitor.1 Strongly activates cystic fibrosis transmembrane conductance regulator (CFTR) chloride channels by inhibiting a membrane associated protein...

  • Focus Biomolecules cell signaling reagent supplier, structure of Cantharidin | Phosphatase PP2A inhibitor | CAS 56-25-7
    $40.00
    Cantharidin (56-25-7) inhibits protein phosphatase 2A (Ki=0.19 μM) and PP1 (Ki=1.1 μM)1. Displays >500-fold selectivity over PP2B. Suppresses growth and migration of PANC-1 pancreatic cancer cells via...

  • Focus Biomolecules supplier, structure Cyclosporin A | Inhibits mitochondrial permeability pore opening | CAS 59865-13-3
    $50.00
    Cyclosporin A (59865-16-6) is an immunosupressant. The CsA-cyclophilin complex binds to and inhibits calcineurin, a type 2B phosphatase. Cell permeable. References/Citations1) Liu et al. (1993), FK506 and cyclosporin:...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of FK-506 | FKBP inhibitor | CAS 104987-11-3
    $48.00
    FK-506 (104987-11-3) induces immunosuppression by inhibiting T cell proliferation. Inhibits FKBP12 and calcineurin (IC50 ~ 1 nM). Cell permeable. References/Citations1) Yu et al. (2006), Effects of cyclosporine A, FK506 and...

  • KY-226 | PTP1B inhibitor
    $65.00
    KY-226 (CAS 1621673-53-7)  is a selective allosteric protein tyrosine phosphatase 1B (PTP1B) inhibitor (IC50 = 250 nM) with no activity at PPARγ.1 It significantly reduced plasma glucose, triglyceride, and A1c...

  • Focus Biomolecules supplier, chemical structure Microcystin LR | Protein phosphatase PP1, PP2A inhibitor | CAS 101043-37-2
    $60.00
    Microcystin LR (CAS 101043-37-2) is a  novel freshwater cyanotoxin.1 Tumor promoter. Potent and selective inhibitor of protein phosphatase 2A (PP2A), IC50=0.04 nM.  PP1, IC50=1.7 nM and PP2B are less sensitive and...

  • Focus Biomolecules supplier, chemical structure of NSC 95397 | CtBP inhibitor; Cdc25 phosphatase inhibitor | CAS 93718-83-3
    $80.00
    NSC 95397 (93718-83-3) is a potent and selective inhibitor of Cdc25 phosphatase (Ki  = 32, 96 and 40 nM for Cdc25A, B and C respectively). NSC-95397 inhibits the growth of several human tumor cell lines and blocks G2/M...

  • NSC-47924 | PHLP phosphatase inhibitor / Laminin inhibitor
    $60.00
    A potent inhibitor of the Leucine-rich repeat protein phosphatase (PHLPP) an enzyme which is a negative regulator of Akt and PKC (IC50=4 μM).1 Increases AKT signaling in cells and prevents apoptosis. Also inhibits the 67...

  • Focus Biomolecules supplier, chemical structure of NSC663284 | Cdc25 phosphatase inhibitor | CAS 383907-43-5
    $90.00
    NSC663284 (383907-43-5) is a potent, selective and irreversible inhibitor of CDC25 phosphatases, Ki=29, 95 and 89 nM for human CDC25A, B2 and C respectively and >20- and >450-fold selective over VHR and PTP1B1. Arrests...

  • Focus Biomolecules cell signaling supplier, chemical structure Okadaic acid | Protein phosphatase inhibitor | CAS 78111-17-8
    $35.00
    Okadaic acid (78111-17-8) is a naturally occurring polyether marine toxin. Potent and selective inhibitor of protein phosphatases inhibiting PP2A completely at 1 nM and PP1 at higher concentrations, while PP2C is not...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure P0180 | PRL-3 phosphatase inhibitor | CAS 893449-38-2
    $60.00
    P0108 (893449-38-2) is a potent inhibitor of phosphatase of regenerating liver-3 (PRL-3), IC50=0.9 μM.1  Reduces the invasive properties of mouse melanoma B16F10 cells in a cellular model.2 Sensitizes...

  • Focus Biomolecules reagent supplier, chemical structure of Salubrinal | eIF2a Phosphatase inhibitor | CAS 405060-95-9
    $80.00
    Salubrinal (405060-95-9) is an endoplasmic reticulum (ER) stress inhibitor. It is a selective inhibitor of cellular complexes that dephosphorylate eukaryotic initiation factor 2 subunit alpha (eIF2α).1 It has been...

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