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  • Focus Biomolecules supplier, chemical structure of Ascomycin | FKBP ligand immunosuppressant | CAS 11011-38-4
    Ascomycin (11011-38-4) is an analog of FK-506 (Cat.# 10-1103). Potent immunosuppressant1. Binds to FKBP122 and inhibits calcineurin and NFAT. Ascomycin displays antiinflammatory effects in skin diseases3. Cell permeable and...

  • Focus Biomolecules supplier, structure Cyclosporin A | Inhibits mitochondrial permeability pore opening | CAS 59865-13-3
    Cyclosporin A (59865-16-6) is an immunosupressant. The CsA-cyclophilin complex binds to and inhibits calcineurin, a type 2B phosphatase. Cell permeable. References/Citations1) Liu et al. (1993), FK506 and cyclosporin:...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of FK-506 | FKBP inhibitor | CAS 104987-11-3
    FK-506 (104987-11-3) induces immunosuppression by inhibiting T cell proliferation. Inhibits FKBP12 and calcineurin (IC50 ~ 1 nM). Cell permeable. References/Citations1) Yu et al. (2006), Effects of cyclosporine A, FK506 and...

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