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BiochemicalTargets

Phosphatases

Phosphatases are hydrolases that catalyze the cleavage of phosphate groups from proteins, carbohydrates (such as inositol), nucleotides, or lipids. Their substrate selectivity can vary greatly, but they are fundamental to cellular function and signaling

Calcineurin (PP2B)

Ascomycin | FKBP ligand/Immunosuppressant

CAS:
11011-38-4
Catalog Number:
10-2059
Activity:
FKBP ligand; immunosuppressant
Alternate Names:
FK-520, FR-900520
Chemical Name:
Fermentation product from Streptomyces hygroscopicus
Molecular Weight:
729.03
Molecular Formula:
C43H69NO12
Solubility:
Soluble in DMSO (up to 50 mg/ml), or in Ethanol (up to 50 mg/ml with warming).
Physical Properties:
White solid
Purity:
99% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT

Cyclosporin A | Inhibits mitochondrial permeability pore opening

CAS:
59865-13-3
Catalog Number:
10-1119
Activity:
Inhibits mitochondrial permeability pore opening
Molecular Weight:
1202.65
Molecular Formula:
C62H111N11O12
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
Physical Properties:
White solid
Purity:
99% by TLC
Storage Temperature:
-20°C
Stability:
Stable for 3 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

FK-506 | FKBP inhibitor

CAS:
104987-11-3
Catalog Number:
10-1103
Activity:
FKBP inhibitor
Alternate Names:
Tacrolimus
Molecular Weight:
804.04
Molecular Formula:
C44H69NO12
Solubility:
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 50 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Shipping Code:
RT

CD45 (PTPRC)

(±) RK-682 | Tyrosine phosphatase inhibitor

CAS:
150627-37-5
Catalog Number:
10-4300
Activity:
Tyrosine phosphatase inhibitor
Chemical Name:
(±)-3-Hexadecanoyl-5-hydroxymethyltetronic acid
Molecular Weight:
368.52
Molecular Formula:
C21H36O5
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 10 mg/ml).
Physical Properties:
Off-white or Yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT

CDC25

NSC95397 | CtBP inhibitor; Cdc25 phosphatase inhibitor

CAS:
93718-83-3
Catalog Number:
10-1565
Activity:
CtBP inhibitor; Cdc25 phosphatase inhibitor
Chemical Name:
2,3-bis[(2-Hydroxyethyl)thiol]-1,4-naphthoquinone
Molecular Weight:
310.39
Molecular Formula:
C14H14O4S2
Solubility:
Soluble in DMSO (up to 15 mg/ml) or in Ethanol (up to 1 mg/ml)
Physical Properties:
Orange solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT

NSC663284 | Cdc25 phosphatase inhibitor

CAS:
383907-43-5
Catalog Number:
10-1352
Activity:
Cdc25 phosphatase inhibitor
Chemical Name:
6-Chloro-7-[[2-(4-morpholinyl)ethyl]amino]-5,8-quinolinedione
Molecular Weight:
321.77
Molecular Formula:
C15H16ClN3O3
Solubility:
Soluble in DMSO (up to 15 mg/ml), or in Ethanol (up to 55 mg/ml).
Physical Properties:
Red solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Shipping Code:
RT

Inositol phosphatase

AS-1949490 | SHIP2 inhibitor

CAS:
1203680-76-5
Catalog Number:
10-5103
Activity:
SHIP2 inhibitor
Chemical Names:
3-[(4-Chlorophenyl)methoxy]-N-[(1S)-1-phenylethyl]- 2-thiophenecarboxamide
Molecular Weight:
371.88
Molecular Formula:
C20H18ClNO2S
Solubility:
Soluble in DMSO (40 mg/ml)
Physical Properties:
Off-white solid
Purity:
98% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 month.
Shipping Code:
RT

PP1

Microcystin LR | Protein phosphatase PP1 and PP2A inhibitor

CAS:
101043-37-2
Catalog Number:
10-2719
Activity:
Protein phosphatase PP1 and PP2A inhibitor
Source:
Isolated from Microcystis aeruginosa, a fresh water cyanobacteria
Molecular Weight:
995.17
Molecular Formula:
C49H74N10O12
Solubility:
Soluble in DMSO, methanol or ethanol
Physical Properties:
Off-white lyophilized solid
Purity:
95% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO, methanol or ethanol may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Okadaic acid | Protein phosphatase inhibitor

CAS:
78111-17-8
Catalog Number:
10-2091
Activity:
Protein phosphatase inhibitor
Source:
Isolated from marine dionflagellates
Molecular Weight:
805.00
Molecular Formula:
C44H68O13
Solubility:
Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 5 mg/ml).
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Cantharidin | Phosphatase PP2A inhibitor

CAS:
56-25-7
Catalog Number:
10-1013
Activity:
Phosphatase PP2A inhibitor
Chemical Name:
3α,7α-Dimethylhexahydro-4,7-epoxyisobenzofuran-1,3-dione
Molecular Weight:
196.2
Molecular Formula:
C10H12O4
Solubility:
Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 5 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 weeks.
Shipping Code:
RT

PP2A

Microcystin LR | Protein phosphatase PP1 and PP2A inhibitor

CAS:
101043-37-2
Catalog Number:
10-2719
Activity:
Protein phosphatase PP1 and PP2A inhibitor
Source:
Isolated from Microcystis aeruginosa, a fresh water cyanobacteria
Molecular Weight:
995.17
Molecular Formula:
C49H74N10O12
Solubility:
Soluble in DMSO, methanol or ethanol
Physical Properties:
Off-white lyophilized solid
Purity:
95% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO, methanol or ethanol may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Okadaic acid | Protein phosphatase inhibitor

CAS:
78111-17-8
Catalog Number:
10-2091
Activity:
Protein phosphatase inhibitor
Source:
Isolated from marine dionflagellates
Molecular Weight:
805.00
Molecular Formula:
C44H68O13
Solubility:
Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 5 mg/ml).
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Cantharidin | Phosphatase PP2A inhibitor

CAS:
56-25-7
Catalog Number:
10-1013
Activity:
Phosphatase PP2A inhibitor
Chemical Name:
3α,7α-Dimethylhexahydro-4,7-epoxyisobenzofuran-1,3-dione
Molecular Weight:
196.2
Molecular Formula:
C10H12O4
Solubility:
Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 5 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 weeks.
Shipping Code:
RT

PTP1B

KY-226 | PTP1B inhibitor

CAS:
1621673-53-7
Catalog Number:
10-4004
Activity:
PTP1B Inhibitor
Chemical Name:
4-(Biphenyl-4-ylmethylsulfanylmethyl)-N-(hexane-1-sulfonyl)benzoylamide
Molecular Weight:
481.67
Molecular Formula:
C27H31NO3S2
Solubility:
Soluble in DMSO (>25 mg/ml).
Physical Properties:
Off-white solid
Purity:
>98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

SHP

SHP099 | SHP2 inhibitor

CAS:
180747-42-4
Catalog Number:
10-4604
Activity:
SHP2 inhibitor
Chemical Name:
6-(4-Amino-4-methylpiperidin-1-yl)-3-(2,3-dichlorophenyl)pyrazin-2-amine dihydrochloride
Molecular Weight:
425.18
Molecular Formula:
C16H19Cl2N5 • 2HCl
Solubility:
Soluble in DMSO (up to 5 mg/ml) or in water (up to at least 20 mg/ml)
Physical Properties:
Yellow solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Other

P053 | Protein phosphatase 5 inhibitor

P053 (1022417-69-1) is a selective inhibitor of protein phosphatase 5 (PP5) – IC50 = 706 nM.1  PP5 regulates signaling cascades that are responsible for tumor initiation,

GSK2830371 | WIP1 phosphatase inhibitor

GSK2830371 is (1404456-53-6) a potent allosteric inhibitor of WIP1 phosphatase (IC50 = 6 nM), a negative regulator of the DNA damage response.1 It displayed no inhibition of 21