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Phosphoinositides

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  • 3-Methyladenine | Autophagosome inhibitor
    3-Methyladenine | Autophagosome inhibitor
    $30.00
    3-Methyladenine (5142-23-4) inhibits autophagy by blocking autophagosome formation via inhibition of type III phosphatidylinositol 3-kinases (PI-3K)1,2. Protects 1321N1 astrocytoma cells against pyocyanin and...

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  • Alamethicin | Pore-forming antimicrobial peptide
    Alamethicin | Pore-forming antimicrobial peptide
    $35.00
    Alamethicin (27061-78-5) is a membrane permeabilizing, pore-forming agent.1 Applications include: [32P] incorporation into phosphatidylinositols2, permeabilization of sarcoplasmic reticulum vesicles3 and mitochondria4 and...

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  • ALLM | 136632-32-1 | Structure | Supplier
    ALLM | Calpain inhibitor
    $60.00
    ALLM (136632-32-1) is a cell-permeable, peptide aldehyde inhibitor of calpain (calpain I, Ki = 120 nM, calpain II, Ki = 230 nM) and other neutral cysteine proteases. Potent inhibitor of cathepsin L (Ki=0.6 nM) and cathepsin...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure AS-041164 | PI 3-Kgamma inhibitor | CAS 6318-41-8
    AS-041164 | PI 3-Kgamma inhibitor
    $60.00
    AS-041164 (6318-41-8) is a potent, ATP-competitive, and isoform-selective PI3-Kinase inhibitor (IC50 = 0.07, 0.24, 1.45, and 1.70 μM for the γ, α, β, and δ isoforms respectively).1 Cell permeable...

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  • BI 2536 | Dual Plk/BRD4 inhibitor - Destabilizes Myc
    BI 2536 | Dual Plk/BRD4 inhibitor - Destabilizes Myc
    $75.00
    BI 2536 (755038-02-9) was originally reported as a potent (IC50’s Plk1 = 0.83nM, Plk2 = 3.5nM and Plk3 = 9.0nM)1 and selective2 Polo-like kinase inhibitor that caused mitotic arrest and apoptosis induction in...

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  • Candesartan | Angiotensin II antagonist
    Candesartan | Angiotensin II antagonist
    $40.00
    Candesartan is an angiotensin II receptor I (AT1) antagonist, IC50s=1.12 and 2.86 nM for bovine adrenal cortex and rabbit aorta respectively.1 Selectively inhibits angiotensin II-induced contraction of rabbit aortic strips...

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  • CK-666 | ARP2/3 inhibitor
    CK-666 | ARP2/3 inhibitor
    $65.00
    CK-666 (442633-00-3) is a potent, selective and reversible inhibitor of ARP2/3 complex (actin related proteins 2 and 3) with an IC50 = 4 µM for human ARP2/3.1 Blocks actin nucleation and radically alters...

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  • CT-2584 | Inhibitor of CTP: choline-phosphate cytidylyltransferase
    CT-2584 | Inhibitor of CTP: choline-phosphate cytidylyltransferase
    $125.00
    CT-2584 (166981-13-1; free base) is a cytotoxic agent that alters phospholipid biosynthesis via inhibition of CTP:choline-phosphate cytidylyltransferase causing an increase in phosphatidylinositol with decreasing levels of...

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  • CTPB | 586976-24-1 | Structure | supplier
    CTPB | p300 HAT activator
    $45.00
    CTPB (586976-24-1) is a selective activator of p300 HAT (histone acetyltransferase) selective over PCAF (p300 CPB-associated factor).1,2 References/Citations 1) Balasubramanyam et al. (2003), Small molecule modulators of...

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  • Custom Quote | Laura Otalora
    $4,500.00
    Bulk Purchase - 1000 mg of 7-Cl-O-Nec1 as quoted.

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  • Deoxymannojirimycin HCl | Mannosidase inhibitor
    Deoxymannojirimycin HCl | Mannosidase inhibitor
    $35.00
    Potent and selective inhibitor of α-mannosidase I.1,2 Inhibits the conversion of high mannose to complex oligosaccharides.3 Attenuates tunicamycin-, thapsigargin- and Aβ1-42-induced ER stress dependent neuronal...

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  • DRB | Transcription inhibitor, CK2 inhibitor
    DRB | Transcription inhibitor, CK2 inhibitor
    $25.00
    DRB (53-85-0) is a classic inhibitor of transcription by RNA polymerase II. A relatively selective inhibitor of Cdk9 (IC50=3 μM), the kinase of the positive transcription elongation factor b (P-TEF-b) required for...

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  • DTG | High affinity sigma receptor agonist
    DTG | High affinity sigma receptor agonist
    $30.00
    DTG (97-39-2) is an agonist of the sigma (σ) receptor1 with roughly equal potency against both subtypes (σ1 and σ2 IC50’s ~ 30nM)2. References/Citations 1) Weber et al. (1986),...

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  • Flecainide acetate | Sodium channel blocker
    Flecainide acetate | Sodium channel blocker
    $50.00
    Flecainide acetate (54143-56-5) is an open Na+ channel blocker that inhibits fast Na+ current in cardiac muscle in a use- and concentration-dependent manner.1 Orally-active class Ic antiarrhythmic agent2,3. Inhibits hERG...

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  • HTS01037 | 682741-29-3 | Structure | Supplier
    HTS01037 | FABP inhibitor
    $60.00
    HTS01037 (682741-29-3) inhibits fatty acid binding proteins.  Inhibits lipolysis in 3T3-L1 adipocytes and reduces LPS-stimulated inflammation in cultured macrophages.  Acts as an antagonist of the protein-protein...

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  • Lorcainide HCl | 58934-46-6 | Structure | Supplier
    Lorcainide HCl | Voltage-gated sodium channel blocker
    $40.00
    Lorcainide hydrochloride (58934-46-6) is a voltage-gated Na+ channel blocker.1 Protects murine cultured cortical neurons from injury induced by oxygen-glucose deprivation.2 Acts at the ouabain binding site of guinea pig...

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  • Focus Biomolecules supplier, chemical structure of LY 294002 | PI 3-Kinase inhibitor | CAS 154447-36-6
    LY 294002 | PI 3-Kinase inhibitor
    $30.00
    LY 294002 (154447-36-6) is a potent and specific inhibitor of phosphatidylinositol-3-kinase (IC50 = 1.40 μM). References/Citations1) Vlahos et al. (1994) A specific inhibitor of phosphatidylinositol 3-kinase,...

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  • LY2603618 | Potent and selective Chk1 inhibitor
    LY2603618 | Potent and selective Chk1 inhibitor
    $75.00
    LY2603618 (911222-45-2)  is a potent (IC50 = 7nM) and selective (>1000x over Chk2) Checkpoint kinase 1 (Chk1) inhibitor.1 Chk1 is an important regulator of the DNA damage response – combination treatment of...

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  • ML210 | GPX4 inhibitor / Ferroptosis inducer
    ML210 | GPX4 inhibitor / Ferroptosis inducer
    $75.00
    ML210 is selectively synthetic lethal to HRAS expressing cells compared to isogenic non-HRAS cells (IC50 = 7.1 nM for BJeLR (expressing HRASg12v) cells vs IC50 = 272 nM for BJeH-LT (non-HRAS expressing) cells.1 ML210 is able...

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  • Mocetinostat | Class I HDAC inhibitor
    Mocetinostat | Class I HDAC inhibitor
    $70.00
    Mocetinostat (726169-73-6) is a class I, isoform-selective HDAC inhibitor, IC50s=0.15, 0.29, 1.66 and 0.59 mM for HDAC1, 2, 3 and 11 respectively.1 Induces hyperacetylation of histones, induces expression of the tumor...

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