Phosphoinositides
Showing 1–12 of 47 results
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Autophagy
3-Methyladenine | Autophagosome inhibitor
3-Methyladenine (5142-23-4) inhibits autophagy by blocking autophagosome formation via inhibition of type III phosphatidylinositol 3-kinases (PI-3K...$30.00 – $90.00 Select options -
Ions and other channels
Alamethicin | Pore-forming antimicrobial peptide
Alamethicin (27061-78-5) is a membrane permeabilizing, pore-forming agent.1 Applications include: [32P] incorporation into phosphatidylinositols2, ...$35.00 – $105.00 Select options -
Phosphatidylinositols
ALLM | Calpain inhibitor
ALLM (136632-32-1) is a cell-permeable, peptide aldehyde inhibitor of calpain (calpain I, Ki = 120 nM, calpain II, Ki = 230 nM) and other neutral c...$60.00 – $175.00 Select options -
Inflammation
AS-041164 | PI 3-Kgamma inhibitor
AS-041164 (6318-41-8) is a potent, ATP-competitive, and isoform-selective PI3-Kinase inhibitor (IC50 = 0.07, 0.24, 1.45, and 1.70 μM for the γ, α, ...$60.00 – $240.00 Select options -
Phosphatidylinositols
BI 2536 | Dual Plk/BRD4 inhibitor – Destabilizes Myc
BI 2536 (755038-02-9) was originally reported as a potent (IC50’s Plk1 = 0.83nM, Plk2 = 3.5nM and Plk3 = 9.0nM)1 and selective2 Polo-like kinase in...$75.00 – $275.00 Select options -
Phosphatidylinositols
Candesartan | Angiotensin II antagonist
Candesartan (CAS 139481-59-7) is an angiotensin II receptor I (AT1) antagonist, IC50s=1.12 and 2.86 nM for bovine adrenal cortex and rabbit aorta r...$40.00 – $120.00 Select options -
Phosphatidylinositols
CK-666 | ARP2/3 inhibitor
CK-666 (442633-00-3) is a potent, selective and reversible inhibitor of ARP2/3 complex (actin related proteins 2 and 3) with an IC50 = 4 µM for hum...$65.00 – $240.00 Select options -
Cancer
CT-2584 | Inhibitor of CTP: choline-phosphate cytidylyltransferase
CT-2584 (166981-13-1; free base) is a cytotoxic agent that alters phospholipid biosynthesis via inhibition of CTP:choline-phosphate cytidylyltransf...$125.00 – $475.00 Select options -
Epigenetics
CTPB | p300 HAT activator
CTPB (586976-24-1) is a selective activator of p300 HAT (histone acetyltransferase) selective over PCAF (p300 CPB-associated factor).1,2 Reference...$45.00 – $180.00 Select options -
Cellular Metabolism
Deoxymannojirimycin HCl | Mannosidase inhibitor
Deoxymannojirimycin HCl (CAS 73465-43-7) is a potent and selective inhibitor of α-mannosidase I.1,2 Inhibits the conversion of high mannose to comp...$35.00 – $112.00 Select options -
Phosphatidylinositols
DRB | Transcription inhibitor, CK2 inhibitor
DRB (53-85-0) is a classic inhibitor of transcription by RNA polymerase II. A relatively selective inhibitor of Cdk9 (IC50=3 μM), the kinase of the...$25.00 – $100.00 Select options -
Phosphatidylinositols
DTG | High affinity sigma receptor agonist
DTG (97-39-2) is an agonist of the sigma (σ) receptor1 with roughly equal potency against both subtypes (σ1 and σ2 IC50’s ~ 30nM)2. References/C...$30.00 – $45.00 Select options
