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Phospholipases

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  • (+/-) RK-682 | Tyrosine phopshatase inhibitor
    (+/-) RK-682 | Tyrosine phopshatase inhibitor
    $75.00
    RK-682 (150627-37-5) is a protein tyrosine phosphatase inhibitor (IC50's = 54 7mu;M for CD45, 2.0 μM for VHR; did not inhibit cdc25B) originally isolated from the fermentation of Streptomyces sp. 88-682.1 Inhibits cell...

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  • ALLM | 136632-32-1 | Structure | Supplier
    ALLM | Calpain inhibitor
    $60.00
    ALLM (136632-32-1) is a cell-permeable, peptide aldehyde inhibitor of calpain (calpain I, Ki = 120 nM, calpain II, Ki = 230 nM) and other neutral cysteine proteases. Potent inhibitor of cathepsin L (Ki=0.6 nM) and cathepsin...

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  • BI 2536 | Dual Plk/BRD4 inhibitor - Destabilizes Myc
    BI 2536 | Dual Plk/BRD4 inhibitor - Destabilizes Myc
    $75.00
    BI 2536 (755038-02-9) was originally reported as a potent (IC50’s Plk1 = 0.83nM, Plk2 = 3.5nM and Plk3 = 9.0nM)1 and selective2 Polo-like kinase inhibitor that caused mitotic arrest and apoptosis induction in...

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  • Candesartan | Angiotensin II antagonist
    Candesartan | Angiotensin II antagonist
    $40.00
    Candesartan is an angiotensin II receptor I (AT1) antagonist, IC50s=1.12 and 2.86 nM for bovine adrenal cortex and rabbit aorta respectively.1 Selectively inhibits angiotensin II-induced contraction of rabbit aortic strips...

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  • CK-666 | ARP2/3 inhibitor
    CK-666 | ARP2/3 inhibitor
    $65.00
    CK-666 (442633-00-3) is a potent, selective and reversible inhibitor of ARP2/3 complex (actin related proteins 2 and 3) with an IC50 = 4 µM for human ARP2/3.1 Blocks actin nucleation and radically alters...

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  • CTPB | 586976-24-1 | Structure | supplier
    CTPB | p300 HAT activator
    $45.00
    CTPB (586976-24-1) is a selective activator of p300 HAT (histone acetyltransferase) selective over PCAF (p300 CPB-associated factor).1,2 References/Citations 1) Balasubramanyam et al. (2003), Small molecule modulators of...

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  • Deoxymannojirimycin HCl | Mannosidase inhibitor
    Deoxymannojirimycin HCl | Mannosidase inhibitor
    $35.00
    Potent and selective inhibitor of α-mannosidase I.1,2 Inhibits the conversion of high mannose to complex oligosaccharides.3 Attenuates tunicamycin-, thapsigargin- and Aβ1-42-induced ER stress dependent neuronal...

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  • Dihydrosphingosine | PKC inhibitor, Sphingosine precursor
    Dihydrosphingosine | PKC inhibitor, Sphingosine precursor
    $30.00
    Dihydrosphingosine (764-22-7) is a biosynthetic precursor of sphingosine. Inhibitor of protein kinase C1 and phospholipases A2 and D2. References/Citations1) Merrill et al. (1989), Structural requirements for long-chain...

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  • DRB | Transcription inhibitor, CK2 inhibitor
    DRB | Transcription inhibitor, CK2 inhibitor
    $25.00
    DRB (53-85-0) is a classic inhibitor of transcription by RNA polymerase II. A relatively selective inhibitor of Cdk9 (IC50=3 μM), the kinase of the positive transcription elongation factor b (P-TEF-b) required for...

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  • DTG | High affinity sigma receptor agonist
    DTG | High affinity sigma receptor agonist
    $30.00
    DTG (97-39-2) is an agonist of the sigma (σ) receptor1 with roughly equal potency against both subtypes (σ1 and σ2 IC50’s ~ 30nM)2. References/Citations 1) Weber et al. (1986),...

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  • Flecainide acetate | Sodium channel blocker
    Flecainide acetate | Sodium channel blocker
    $50.00
    Flecainide acetate (54143-56-5) is an open Na+ channel blocker that inhibits fast Na+ current in cardiac muscle in a use- and concentration-dependent manner.1 Orally-active class Ic antiarrhythmic agent2,3. Inhibits hERG...

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  • HTS01037 | 682741-29-3 | Structure | Supplier
    HTS01037 | FABP inhibitor
    $60.00
    HTS01037 (682741-29-3) inhibits fatty acid binding proteins.  Inhibits lipolysis in 3T3-L1 adipocytes and reduces LPS-stimulated inflammation in cultured macrophages.  Acts as an antagonist of the protein-protein...

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  • Lorcainide HCl | 58934-46-6 | Structure | Supplier
    Lorcainide HCl | Voltage-gated sodium channel blocker
    $40.00
    Lorcainide hydrochloride (58934-46-6) is a voltage-gated Na+ channel blocker.1 Protects murine cultured cortical neurons from injury induced by oxygen-glucose deprivation.2 Acts at the ouabain binding site of guinea pig...

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  • LY2603618 | Potent and selective Chk1 inhibitor
    LY2603618 | Potent and selective Chk1 inhibitor
    $75.00
    LY2603618 (911222-45-2)  is a potent (IC50 = 7nM) and selective (>1000x over Chk2) Checkpoint kinase 1 (Chk1) inhibitor.1 Chk1 is an important regulator of the DNA damage response – combination treatment of...

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  • m-3M3FBS | Phospholipase C activator
    m-3M3FBS | Phospholipase C activator
    $75.00
    m-3M3FBS (200933-14-8) is an activator of phospholipase C (PLC). Stimulates superoxide generation, Ca2+ release and inositol phosphate release in a variety of cell types1. Inhibits growth of U937 and THP-1 cells2. m-3M3FBS...

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  • ML210 | GPX4 inhibitor / Ferroptosis inducer
    ML210 | GPX4 inhibitor / Ferroptosis inducer
    $75.00
    ML210 is selectively synthetic lethal to HRAS expressing cells compared to isogenic non-HRAS cells (IC50 = 7.1 nM for BJeLR (expressing HRASg12v) cells vs IC50 = 272 nM for BJeH-LT (non-HRAS expressing) cells.1 ML210 is able...

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  • Mocetinostat | Class I HDAC inhibitor
    Mocetinostat | Class I HDAC inhibitor
    $70.00
    Mocetinostat (726169-73-6) is a class I, isoform-selective HDAC inhibitor, IC50s=0.15, 0.29, 1.66 and 0.59 mM for HDAC1, 2, 3 and 11 respectively.1 Induces hyperacetylation of histones, induces expression of the tumor...

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  • Naloxone HCl | Opioid receptor antagonist
    Naloxone HCl | Opioid receptor antagonist
    $50.00
    Naloxone (357-08-4) is a pan-opioid receptor antagonist, Ki=3.7, 9.2 and 33 nM for m, k and d opioid receptors respectively1. In clinical use in opiate abuse and overdose rescue.2 Blocks opiate- promoted wound healing.3...

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  • Necrosulfonamide | Necroptosis inhibitor / MLKL inhibitor
    Necrosulfonamide | Necroptosis inhibitor / MLKL inhibitor
    $40.00
    Necrosulfonamide (1360614-48-7) specifically blocks necroptosis downstream of RIP3 activation by preventing MLKL-RIP3 interaction.1 Displays neuroprotective effects after ischemic brain injury.2 Prevents...

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  • NOBA | 55894-52-5 | Structure | Supplier
    NOBA | Phospholipase substrate
    $80.00
    NOBA (55894-52-5) is a chromogenic substrate for phospholipases such as PLA2. Read absorbance at 425 nm. References/Citations1) Cho & Kezdy (1991), Chromogenic Substrates and assay of phospholipases A2; Methods Enzymol...

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