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Phospholipases

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  • Focus Biomolecules reagent supplier, chemical structure of (+/-) RK-682 | Tyrosine phosphatase inhibitor | CAS 150627-37-5
    $75.00
    RK-682 (150627-37-5) is a protein tyrosine phosphatase inhibitor (IC50's = 54 7mu;M for CD45, 2.0 μM for VHR; did not inhibit cdc25B) originally isolated from the fermentation of Streptomyces sp. 88-682.1 Inhibits cell...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of ALLM | Calpain inhibitor | CAS 136632-32-1
    $60.00
    ALLM (136632-32-1) is a cell-permeable, peptide aldehyde inhibitor of calpain (calpain I, Ki = 120 nM, calpain II, Ki = 230 nM) and other neutral cysteine proteases. Potent inhibitor of cathepsin L (Ki=0.6 nM) and cathepsin...

  • AS-1949490 | SHIP2 inhibitor
    $62.00
    AS-1949490 (1203680-76-5) is a potent and selective inhibitor of the intracellular phosphatase SHIP2 (SH2 domain-containing inositol 5'-phosphatase 2),IC50 = 0.62 μM.1 Displays ca. 30-fold selectivity for SHIP2 over SHIP1...

  • Focus Biomolecules supplier, chemical structure of BI 2536 | Dual Plk/BRD4 inhibitor - Destabilizes Myc | CAS 755038-02-9
    $75.00
    BI 2536 (755038-02-9) was originally reported as a potent (IC50’s Plk1 = 0.83nM, Plk2 = 3.5nM and Plk3 = 9.0nM)1 and selective2 Polo-like kinase inhibitor that caused mitotic arrest and apoptosis induction in...

  • Bromosporine | Pan-bromodomain inhibitor
    $80.00
    Bromosporine (1619994-69-2) is a potent pan-Bromodomain (BRD) inhibitor.1 Bromosporine was able to reactivate HIV-1 replication in different latency models.2 References/Citations 1) Picaud et al. (2016), Promiscuous...

  • Focus Biomolecules cell signaling supplier, chemical structure of Candesartan | Angiotensin II antagonist | CAS 139481-59-7
    $40.00
    Candesartan (CAS 139481-59-7) is an angiotensin II receptor I (AT1) antagonist, IC50s=1.12 and 2.86 nM for bovine adrenal cortex and rabbit aorta respectively.1 Selectively inhibits angiotensin II-induced contraction of...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of CK-666 | ARP2/3 inhibitor | CAS 442633-00-3
    $65.00
    CK-666 (442633-00-3) is a potent, selective and reversible inhibitor of ARP2/3 complex (actin related proteins 2 and 3) with an IC50 = 4 µM for human ARP2/3.1 Blocks actin nucleation and radically alters...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of CTPB | p300 HAT activator | CAS 586976-24-1
    $45.00
    CTPB (586976-24-1) is a selective activator of p300 HAT (histone acetyltransferase) selective over PCAF (p300 CPB-associated factor).1,2 References/Citations 1) Balasubramanyam et al. (2003), Small molecule modulators of...

  • $4,500.00
    Bulk Purchase - 1000 mg of 7-Cl-O-Nec1 as quoted.

  • Focus Biomolecules reagent supplier, chemical structure of Deoxymannojirimycin HCl | Mannosidase inhibitor | CAS 73465-43-7
    $35.00
    Deoxymannojirimycin HCl (CAS 73465-43-7) is a potent and selective inhibitor of α-mannosidase I.1,2 Inhibits the conversion of high mannose to complex oligosaccharides.3 Attenuates tunicamycin-, thapsigargin- and...

  • Focus Biomolecules supplier, chemical structure of Dihydrosphingosine | PKC inhibitor, Sphingosine precursor | CAS 764-22-7
    $25.00
    Dihydrosphingosine (764-22-7) is a biosynthetic precursor of sphingosine. Inhibitor of protein kinase C1 and phospholipases A2 and D2. References/Citations1) Merrill et al. (1989), Structural requirements for long-chain...

  • Focus Biomolecules cell signaling supplier, chemical structure of DRB | Transcription inhibitor, CK2 inhibitor | CAS 53-85-0
    $25.00
    DRB (53-85-0) is a classic inhibitor of transcription by RNA polymerase II. A relatively selective inhibitor of Cdk9 (IC50=3 μM), the kinase of the positive transcription elongation factor b (P-TEF-b) required for...

  • Focus Biomolecules cell signaling supplier, chemical structure of DTG | High affinity sigma receptor agonist | CAS 97-39-2
    $30.00
    DTG (97-39-2) is an agonist of the sigma (σ) receptor1 with roughly equal potency against both subtypes (σ1 and σ2 IC50’s ~ 30nM)2. References/Citations 1) Weber et al. (1986),...

  • Filgotinib | JAK1 inhibitor
    $65.00
    Filgotinib (1206161-97-8) is a potent and selective JAK1 inhibitor (IC50s=10, 28, 810 and 116 nM for JAK1, JAK2, JAK3 and TYK2 respectively.2  Displays potent anti-inflammatory activity in various models.1,2 ...

  • Focus Biomolecules cell signaling supplier, chemical structure Flecainide acetate | Sodium channel blocker | CAS 54143-56-5
    $50.00
    Flecainide acetate (54143-56-5) is an open Na+ channel blocker that inhibits fast Na+ current in cardiac muscle in a use- and concentration-dependent manner.1 Orally-active class Ic antiarrhythmic agent2,3. Inhibits hERG...

  • HA-100 2HCl | Multi-kinase inhibitor
    $58.00
    HA-100 2HCl (85568-24-6) inhibits the following kinases  PKG (IC50=4 mM), PKA (IC50=8 mM), PKC (IC50=12 mM).1 Increases human fibroblast reprogramming efficiency with PD0325901, CHIR99021, A83-01 and hLIF.2 Improves...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of HTS01037 | FABP inhibitor | CAS 682741-29-3
    $60.00
    HTS01037 (682741-29-3) inhibits fatty acid binding proteins.  Inhibits lipolysis in 3T3-L1 adipocytes and reduces LPS-stimulated inflammation in cultured macrophages.  Acts as an antagonist of the protein-protein...

  • Idelalisib | Selective PI3Kd Inhibitor
    $60.00
    Idelalisib (CAS 870281-82-6) is a potent (IC50 = 2.5nM) and selective (IC50’s: PI3Ka = 820nM, PI3Kb = 565nM, PI3Kg = 89nM) PI3Kd inhibitor.1,2 Useful clinical agent for the treatment of various blood cancers...

  • IM-12 | GSK-3 beta inhibitor
    $52.00
    IM-12 (129669-05-1) is a potent and selective inhibitor of glycogen synthase kinase 3β; (GSK-3β) IC50=53 nM which induces neuronal differentiation.1 Activates the Wnt-β-catenin signaling pathway and attenuates...

  • IWR-1 endo | Wnt signaling inhibitor
    $50.00
    IWR-1 endo (1127442-82-3) is a potent inhibitor of Wnt signaling (IC50=180 nM).1 Inhibits zebrafish tailfin regeneration (0.5 mM).2 Acts via inhibition of tankyrase and attenuates Wnt/β-catenin signaling in cancer...

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