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  • ALLM | 136632-32-1 | Structure | Supplier
    ALLM (136632-32-1) is a cell-permeable, peptide aldehyde inhibitor of calpain (calpain I, Ki = 120 nM, calpain II, Ki = 230 nM) and other neutral cysteine proteases. Potent inhibitor of cathepsin L (Ki=0.6 nM) and cathepsin...

  • BI 2536 | Dual Plk/BRD4 inhibitor - Destabilizes Myc
    BI 2536 (755038-02-9) was originally reported as a potent (IC50’s Plk1 = 0.83nM, Plk2 = 3.5nM and Plk3 = 9.0nM)1 and selective2 Polo-like kinase inhibitor that caused mitotic arrest and apoptosis induction in...

  • Candesartan | Angiotensin II antagonist
    Candesartan is an angiotensin II receptor I (AT1) antagonist, IC50s=1.12 and 2.86 nM for bovine adrenal cortex and rabbit aorta respectively.1 Selectively inhibits angiotensin II-induced contraction of rabbit aortic strips...

  • CK-666 | ARP2/3 inhibitor
    CK-666 (442633-00-3) is a potent, selective and reversible inhibitor of ARP2/3 complex (actin related proteins 2 and 3) with an IC50 = 4 µM for human ARP2/3.1 Blocks actin nucleation and radically alters...

  • CTPB | 586976-24-1 | Structure | supplier
    CTPB (586976-24-1) is a selective activator of p300 HAT (histone acetyltransferase) selective over PCAF (p300 CPB-associated factor).1,2 References/Citations 1) Balasubramanyam et al. (2003), Small molecule modulators of...

  • $4,500.00
    Bulk Purchase - 1000 mg of 7-Cl-O-Nec1 as quoted.

  • Deoxymannojirimycin HCl | Mannosidase inhibitor
    Potent and selective inhibitor of α-mannosidase I.1,2 Inhibits the conversion of high mannose to complex oligosaccharides.3 Attenuates tunicamycin-, thapsigargin- and Aβ1-42-induced ER stress dependent neuronal...

  • DRB | Transcription inhibitor, CK2 inhibitor
    DRB (53-85-0) is a classic inhibitor of transcription by RNA polymerase II. A relatively selective inhibitor of Cdk9 (IC50=3 μM), the kinase of the positive transcription elongation factor b (P-TEF-b) required for...

  • DTG | High affinity sigma receptor agonist
    DTG (97-39-2) is an agonist of the sigma (σ) receptor1 with roughly equal potency against both subtypes (σ1 and σ2 IC50’s ~ 30nM)2. References/Citations 1) Weber et al. (1986),...

  • Flecainide acetate | Sodium channel blocker
    Flecainide acetate (54143-56-5) is an open Na+ channel blocker that inhibits fast Na+ current in cardiac muscle in a use- and concentration-dependent manner.1 Orally-active class Ic antiarrhythmic agent2,3. Inhibits hERG...

  • HTS01037 | 682741-29-3 | Structure | Supplier
    HTS01037 (682741-29-3) inhibits fatty acid binding proteins.  Inhibits lipolysis in 3T3-L1 adipocytes and reduces LPS-stimulated inflammation in cultured macrophages.  Acts as an antagonist of the protein-protein...

  • Lorcainide HCl | 58934-46-6 | Structure | Supplier
    Lorcainide hydrochloride (58934-46-6) is a voltage-gated Na+ channel blocker.1 Protects murine cultured cortical neurons from injury induced by oxygen-glucose deprivation.2 Acts at the ouabain binding site of guinea pig...

  • LY2603618 | Potent and selective Chk1 inhibitor
    LY2603618 (911222-45-2)  is a potent (IC50 = 7nM) and selective (>1000x over Chk2) Checkpoint kinase 1 (Chk1) inhibitor.1 Chk1 is an important regulator of the DNA damage response – combination treatment of...

  • m-3M3FBS | Phospholipase C activator
    m-3M3FBS (200933-14-8) is an activator of phospholipase C (PLC). Stimulates superoxide generation, Ca2+ release and inositol phosphate release in a variety of cell types1. Inhibits growth of U937 and THP-1 cells2. m-3M3FBS...

  • ML210 | GPX4 inhibitor / Ferroptosis inducer
    ML210 is selectively synthetic lethal to HRAS expressing cells compared to isogenic non-HRAS cells (IC50 = 7.1 nM for BJeLR (expressing HRASg12v) cells vs IC50 = 272 nM for BJeH-LT (non-HRAS expressing) cells.1 ML210 is able...

  • Mocetinostat | Class I HDAC inhibitor
    Mocetinostat (726169-73-6) is a class I, isoform-selective HDAC inhibitor, IC50s=0.15, 0.29, 1.66 and 0.59 mM for HDAC1, 2, 3 and 11 respectively.1 Induces hyperacetylation of histones, induces expression of the tumor...

  • Naloxone HCl | Opioid receptor antagonist
    Naloxone (357-08-4) is a pan-opioid receptor antagonist, Ki=3.7, 9.2 and 33 nM for m, k and d opioid receptors respectively1. In clinical use in opiate abuse and overdose rescue.2 Blocks opiate- promoted wound healing.3...

  • Necrosulfonamide | Necroptosis inhibitor / MLKL inhibitor
    Necrosulfonamide (1360614-48-7) specifically blocks necroptosis downstream of RIP3 activation by preventing MLKL-RIP3 interaction.1 Displays neuroprotective effects after ischemic brain injury.2 Prevents...

  • Optovin | 348575-88-2 | Structure | supplier
    Optovin (348575-88-2) is a reversible photoactive TRPA1 activator. Optovin stimulates human TRPA1 channels and enables repeated photoactivation of motor behaviors in wild-type zebrafish (EC50 = 2 μM) and mice, in vivo...

  • Palbociclib | CDK4/CDK6 inhibitor
    Palbociclib (571190-30-2) is a potent and selective inhibitor of Cdk4, IC50 = 11 nM and Cdk6, IC50 = 16 nM.1 Inhibits phosphorylation of Rb protein and cell cycle progression through G1 in primary 5T33MM cells and...

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