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SGC707 | PRMT3 inhibitor

CAS:
1687736-54-4
Catalog Number:
10-1610
Activity:
PRMT3 inhibitor
Chemical Name:
1-Isoquinolin-6-yl-3-(2-oxo-2-pyrrolidin-1-yl-ethyl)-urea
Molecular Weight:
298.34
Molecular Formula:
C16H18N4O2
Solubility:
Soluble in DMSO (up to 35 mg/ml)
Physical Properties:
Beige solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

SGC707 (1687736-54-4) is a potent (IC50 = 31 nM) and selective allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3).1  Selective against 31 other methyltransferases. An extremely useful probe for investigating the role of PRMT3 in normal and pathophysiology. Cell permeable and active in vivo.

References/Citations:

1) Kaniskan et al. (2015), A potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3); Angew. Chem. Int. Ed. Engl., 54 5166

SGC707 | PRMT3 inhibitor is also available in the Cellular Metabolism Library.
CAS:
1687736-54-4
Catalog Number:
10-1610
Activity:
PRMT3 inhibitor
Chemical Name:
1-Isoquinolin-6-yl-3-(2-oxo-2-pyrrolidin-1-yl-ethyl)-urea
Molecular Weight:
298.34
Molecular Formula:
C16H18N4O2
Solubility:
Soluble in DMSO (up to 35 mg/ml)
Physical Properties:
Beige solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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