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Product Details

Pranlukast | Leukotriene CysLT1 antagonist / GRP17 antagonist

Pranlukast (103177-37-3)is a selective Leukotriene CysLT1 antagonist1 and has been used in the treatment of asthma2. Pranlukast is also an inhibitor of GPR173 (IC50’s = 10.5nM hGPR17, 31nM rGPR17) and is superior to Montelukast in achieving functional inhibition4.

References/Citations

1) Nakai et al. (1988), New Potent Antagonists of Leukotrienes C4 and D4. 1. Synthesis and Structure-Activity Relationships; J. Med. Chem. 31 84
2) Taniguchi et al. (1993), The effect of an oral leukotriene antagonist, ONO-1078, on allergen-induced immediate bronchoconstriction in asthmatic subjects; J. Allergy Clin. Immunol. 92 507
3) Ciana et al. (2006), The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptor; EMBO J. 25 4615
4) Hennen et al. (2013), Decoding Signaling and Function of the Orphan G Protein-Coupled Receptor GPR17 with a Small-Molecule Agonist; Sci. Signal. 6 ra93

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Catalog#  10-2441

$50.00
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CAS:
103177-37-3
Catalog Number:
10-2441
Activity:
Leukotriene CysLT1 antagonist / GRP17 antagonist
Chemical Name:
N-[4-oxo-2-(2H-tetrazol-5-yl)chromen-8-yl]-4-(4-phenylbutoxy)benzami
Alternate Names:
ONO-1078
Molecular Weight:
481.51
Molecular Formula:
C27H23N5O4
Solubility:
Soluble in DMSO (up to 25 mg/ml)
Physical Properties:
White solid
Purity:
98%
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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