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  • Aclacinomycin A | 57576-44-0 | Structure | Supplier
    Aclacinomycin A HCl (75443-99-1) is a specific inhibitor of the 20S proteasome chymotrypsin-like activity.1 Inhibition of Brg1 proteasomal degradation by aclacinomycin A reverses (0.25 μM in ILU-18 cells ) the removal of...

  • Bz-Val-Gly-Arg-AMC | Proteasome substrate
    Bz-VGR-AMC (87779-49-5) may be used for measuring the trypsin-like activity of the 20S proteasome, in combination with Suc-LLVY-AMC (Cat.# 10-2971, for assaying its chymotrypsin-like activity) and Z-LLE-AMC, (for determining...

  • Carfilzomib | 868540-17-4 | Structure | supplier
    Carfilzomib (868540-17-4) is a potent and irreversible proteasome inhibitor.1 Synthetic analog of the microbial product epoxomcin.2 Compared to bortezomib it displays equal potency but greater selectivity for the...

  • Celastrol | Proteasome inhibitor
    Celastrol (34157-83-0) displays potent antioxidant and anti-inflammatory activity. Inhibits NFkB (IC50=270 nM).  It induces heat shock response and cytoprotection in various cells. Inhibits 20S proteasome chymotrypsin...

  • Epoxomicin | 134381-21-8 | Structure | Supplier
    Epoxomicin (134381-21-8) is a potent, selective and cell permeable irreversible inhibitor of the 20S proteasome.1 It does not inhibit non-proteasomal proteases such as papain, chymotrypsin, trypsin, calpain and cathepsin B...

  • IU1 | 314245-33-5 | Structure | Supplier
    IU1 (314245-33-5) is a selective inhibitor of Usp14 (IC50<4 μM). Enhances proteasome activity and substrate proteolysis.1,2 Inhibits Dengue virus replication.3 In prion-infected CAD5 cells activation of the...

  • Lactacystin | 133343-34-7 | Structure | Supplier
    Lactacyctin (133343-34-7) is a specific inhibitor of three proteolytic activities of the proteasome. Chymotrypsin-like activity is inhibited most potently followed by trypsin-like activity. Inhibition of the...

  • MG-132 | 133407-82-6 | Structure | Supplier
    MG-132 (133407-82-6) is a specific inhibitor of the chymotrypsin-like activity of the 20S proteasome (IC50=100 nM with Z-LLL-AMC as substrate).1 Also inhibits calpain (IC50=1.25 μM).1 Suppresses gastric cancer cell...

  • Spautin-1 | 1262888-28-7 | Structure | Supplier
    Spautin-1 (1262888-28-7) is a specific and potent autophagy inhibitor. Spautin-1 promotes the degradation of Vps34 PI3 kinase complexes by inhibiting two ubiquitin-specific proteases USP10 and USP13 which target the Beclin-1...

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