Protein-protein interactions
Showing 1–12 of 15 results
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Bioactive Lipids
2-Bromopalmitic acid | Palmitoylation inhibitor
2-Bromopalmitic acid (18263-25-7) inhibits protein S-palmitoylation.1 Blocks palmitic acid-induced increase in cAMP levels in human primary melanoc...$40.00 – $100.00 Select options -
Antioxidants
AI-3 | ARE activator
AI-3 (882288-28-0) is an activator of antioxidant response element (ARE) which induces cytoprotective genes in human cells. It alkylates Keap1 at C...$75.00 – $300.00 Select options -
Apoptosis
CFM-4 | CARP-1 mimetic
CFM-4 (331458-02-7) is a CARP-1 functional mimetic that interferes with CARP-1 binding to APC-2 (IC50=10-15 μM)1. Enhances CARP-1 expression and in...$70.00 – $280.00 Select options -
Alzheimers
Compound 115-7c | HSP70 modulator
Compound 115-7c (908074-72-6) acts as an artificial co-chaperone for HSP70.1 The activity of compound 115-7c mirrors those of HSP40 stimulating the...$90.00 – $360.00 Select options -
b-Catenin/CBP
ICG-001 | Wnt beta-catenin inhibitor
ICG-001 (847591-62-2) inhibits TCF/β-catenin mediated transcription by specifically blocking β-catenin/CBP interaction References/Citations 1...$65.00 – $250.00 Select options -
b-Catenin/CBP
iCRT5 | Beta-catenin inhibitor
iCRT5 (18623-44-4) is a selective CRT (β-catenin-responsive transcription) inhibitor.1 IC50=18 nM for Wnt responsive STF16 luciferase. Acts via in...$57.00 – $228.00 Select options -
Bromodomains
JQ1 | Bromodomain inhibitor
(±) JQ1 (1268524-69-1) is a potent BET bromodomain inhibitor. IC50 = 17.7, 32.6, 76.9 and 12942 nM respectively for BRD2 (N-terminal (N)), BRD4 (C-...$65.00 – $260.00 Select options -
Other Protein-protein interactions
L524-0366 | Fn14 antagonist
L524-0366 (951612-19-4) is an Fn14 antagonist. Competes with TNF-like weak inducer of apoptosis (TWEAK) C-terminal/extracellular TNF homology domai...$65.00 – $260.00 Select options -
Cholinergics
NSC-23766 | Rac1 GTPase inhibitor
NSC-23766 (733767-34-5) is a selective inhibitor of Rac1-GEF interaction. Prevents Rac1 activation by Rac-specific guanine nucleotide exchange fact...$67.00 – $270.00 Select options -
Cancer
NSC-66811 | p53/mdm2 inhibitor
NSC-66811 (6964-62-1) is a novel inhibitor of the MDM2-p53 interaction. Mimics three p53 residues involved in binding to MDM2. NSC-66811 binds to M...$100.00 – $400.00 Select options -
Cancer
NSC59984 | p53 activator
NSC59984 (803647-40-7) is a p53 activator. Restores wild-type p53 signaling and depletes mutant p53 gain of function. Induces mutant p53 protein d...$50.00 – $150.00 Select options -
Apoptosis
Nutlin-3 | p53/mdm2 inhibitor
Nutlin-3 (548472-68-0) is an MDM2 antagonist; inhibits the MDM2-p53 interaction (IC50 = 0.09 μM) and activates p531. Nutlin-3 displays antiprolifer...$100.00 – $400.00 Select options
