Pulmonary
Showing 1–12 of 24 results
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Cancer
AG 1478 | EGFR kinase inhibitor
AG-1478 (175478-82-2; base) is a potent and selective inhibitor of the EGFR kinase (IC50 = 3 nM). Inhibits proliferation of a variety human cancer ...$50.00 – $150.00 Select options -
Antioxidants
Ambroxol HCl | Free radical scavenger
Ambroxol HCl (18683-91-5) is a radical scavenger with anti-inflammatory activity. Blocks the generation of reactive oxygen species by bronchoalveol...$50.00 – $100.00 Select options -
New Products
BI 749327 | Selective TRPC6 blocker
BI 749327 (2361241-23-6) is a potent (IC50 = 13 nM mouse TRPC6, 19 nM human TRPC6) and selective (85-fold over TRPC3, 42-fold over TRC7) orally ava...$80.00 – $300.00 Select options -
Bioinorganic chemistry
Bleomycin sulfate | Induces double strand DNA breaks
Bleomycin sulfate (9041-93-4) coordinates with metals producing reactive oxygen species which causes oxidative damage to DNA1 and RNA2. Induces dou...$75.00 – $250.00 Select options -
Asthma
Cilostamide | PDE3 inhibitor
Cilostamide (68550-75-4) is a selective inhibitor of phosphodiesterase-3 (PDE3). Displays limited selectivity for PDE3A versus PDE3B (IC50 = 27 and...$60.00 – $240.00 Select options -
Approved Drugs
Fasudil HCl | ROCK inhibitor
Fasudil HCl (105628-07-7) is a Rho-associated kinase inhibitor (IC50 = 1.9 μM and 10.7 μM for Rho-associated kinase II and Rho-associated kinase re...$45.00 – $150.00 Select options -
Adrenergic
Formoterol hemifumarate | ß2 adrenergic agonist
Formoterol hemifumarate (43229-80-7) is a potent, long-acting agonist specific to β2 (Ki = 7.6 nM), but not β1 (Ki > 2.6 µM), adrenergic recepto...$68.00 – $200.00 Select options -
Bioactive Lipids
Ginkgolide B | PAF receptor antagonist
Ginkgolide B (15291-77-7) is a PAF receptor antagonist (Ki = 1.3 μM)1. Inhibits neutrophil degranulation and superoxide production in vitro1. Inhib...$40.00 – $160.00 Select options -
New Products
GW788388 | TGF-ß receptor kinase inhibitor
GW788388 (452342-67-5) is a potent inhibitor of TGF-β receptor kinases ALK4, ALK5 (IC50=18 nM), ALK7, and TGFβRII, but not BMP type II receptor kin...$80.00 – $260.00 Select options -
Asthma
ISO-1 | MIF antagonist
ISO-1 (478336-92-4) is an antagonist of macrophage migration inhibitory factor (MIF, a pro-inflammatory cytokine). Displays anti-inflammatory activ...$105.00 – $420.00 Select options -
Approved Drugs
Minocycline HCl | Neuroprotective/anti-inflammatory
Minocycline HCl (13614-98-7) displays antiapoptotic, anti-inflammatory1 activity. Prevents neuropathic pain in a rat sciatic nerve injury model.1 R...$38.00 – $152.00 Select options -
Cellular Stress
Monocrotaline | Induces pulmonary fibrosis
Monocrotaline (315-22-0) is a naturally occurring pyrrolizidine alkaloid used to create an animal model of pulmonary arterial hypertension (PAH). I...$49.00 – $105.00 Select options
