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Pulmonary

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of AG 1478 | EGFR kinase inhibitor | CAS 175178-82-2
    AG 1478 | EGFR kinase inhibitor
    $50.00
    AG-1478 (175478-82-2; base) is a potent and selective inhibitor of the EGFR kinase (IC50 = 3 nM). Inhibits proliferation of a variety human cancer cell lines1,2. AG-1478 reduces pulmonary fibrosis in a rat model3. Cell...

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  • Focus Biomolecules cell signaling tech supplier, chemical structure Ambroxol HCl | Free radical scavenger | CAS 18683-91-5
    Ambroxol HCl | Free radical scavenger
    $50.00
    Ambroxol HCl (18683-91-5) is a radical scavenger with anti-inflammatory activity. Blocks the generation of reactive oxygen species by bronchoalveolar lavage cells, inhibits doxorubicin-induced lipid peroxidation (70 mg/kg in...

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  • Focus Biomolecules supplier, chemical structure of Bleomycin sulfate | Induces double strand DNA breaks | CAS 9041-93-4
    Bleomycin sulfate | Induces double strand DNA breaks
    $90.00
    Bleomycin sulfate (9041-93-4) coordinates with metals producing reactive oxygen species which causes oxidative damage to DNA1 and RNA2. Induces double-strand DNA damage.3 Commonly used to induce lung fibrosis in animal...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Cilostamide | PDE3 inhibitor | CAS 68550-75-4
    Cilostamide | PDE3 inhibitor
    $60.00
    Cilostamide (68550-75-4) is a selective inhibitor of phosphodiesterase-3 (PDE3). Displays limited selectivity for PDE3A versus PDE3B (IC50 = 27 and 50 nM)1,2. Blocks PKB/Akt signaling pathway downstream via inhibition of...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Fasudil HCl | ROCK inhibitor | CAS 105628-07-7
    Fasudil HCl | ROCK inhibitor
    $45.00
    Fasudil HCl (105628-07-7) is a Rho-associated kinase inhibitor (IC50 = 1.9 μM and 10.7 μM for Rho-associated kinase II and Rho-associated kinase respectively)1. Inhibits other kinases including cyclic...

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  • Focus Biomolecules cell signaling reagent supplier, structure of Ginkgolide B | PAF receptor antagonist | CAS 15291-77-7
    Ginkgolide B | PAF receptor antagonist
    $40.00
    Ginkgolide B (15291-77-7) is a PAF receptor antagonist (Ki = 1.3 μM)1. Inhibits neutrophil degranulation and superoxide production in vitro1. Inhibits PAF-induced bronchoconstriction in a guinea pig model...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of ISO-1 | MIF antagonist | CAS 478336-92-4
    ISO-1 | MIF antagonist
    $105.00
    ISO-1 (478336-92-4) is an antagonist of macrophage migration inhibitory factor (MIF, a pro-inflammatory cytokine). Displays anti-inflammatory activity. Increases survival in severe sepsis1. Inhibits airway remodeling in...

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  • Focus Biomolecules supplier, chemical structure of Minocycline HCl | Neuroprotective | Antiapoptotic | CAS 13614-98-7
    Minocycline HCl | Neuroprotective; antiapoptotic
    $38.00
    Minocycline HCl (13614-98-7) displays antiapoptotic, anti-inflammatory1 activity. Prevents neuropathic pain in a rat sciatic nerve injury model1. Reduces MMP-9 activity2. Attenuates disease severity in mouse models of...

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  • Focus Biomolecules cell signaling supplier, chemical structure of Monocrotaline | Induces pulmonary fibrosis | CAS 315-22-0
    Monocrotaline | Induces pulmonary fibrosis
    $49.00
    Monocrotaline (315-22-0) is a naturally occurring pyrrolizidine alkaloid used to create an animal model of pulmonary arterial hypertension (PAH). It can mimic several important aspects of human PAH including vascular...

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  • Focus Biomolecules supplier, chemical structure of Montelukast sodium | Leukotriene & GPR17 antagonist | CAS 151767-02-1
    Montelukast sodium | Leukotriene antagonist and GPR17 antagonist
    $60.00
    Montelukast sodium (151767-02-1) is a potent, selective CysLT1 receptor (leukotriene D4) antagonist (Ki = 0.18 nM).1,2 Displays anti-inflammatory and anti-asthmatic effects. Clinically useful agent for treatment of chronic...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Pirfenidone | Antifibrotic | CAS 53179-13-8
    Pirfenidone | Antifibrotic
    $30.00
    Pirfenidone (53179-13-8) is an antifibrotic agent. Prevents lung fibrosis in bleomycin-induced animal models.1 Down-regulates bleomycin-induced overexpression of lung procollagen I and III genes.2 Up-regulates RGS2...

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  • Pranlukast | Leukotriene CysLT1 antagonist / GPR17 antagonist
    Pranlukast | Leukotriene CysLT1 antagonist / GPR17 antagonist
    $50.00
    Pranlukast (103177-37-3)is a selective Leukotriene CysLT1 antagonist1 and has been used in the treatment of asthma2. Pranlukast is also an inhibitor of GPR173 (IC50’s = 10.5nM hGPR17, 31nM rGPR17) and is superior to...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of SB-216763 | GSK-3 inhibitor | CAS 280744-09-4
    SB-216763 | GSK-3 inhibitor
    $50.00
    SB-216763 (280744-09-4) is a potent and selective inhibitor of glycogen synthase kinase-1 (GSK-3) IC50=34.3 nM1. Acts at the ATP-binding domain. Displays protective effects in lung fibrosis mouse model2. Displays...

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  • Focus Biomolecules cell signaling supplier, chemical structure of SB-525334 | ALK5 (TGFbeta R1) inhibitor | CAS 356559-20-1
    SB-525334 | ALK5 (TGFbeta R1) inhibitor
    $60.00
    SB-525334 (356559-20-1) is a potent and selective inhibitor of the transforming growth factor beta 1 receptor, activin receptor-like kinase (ALK5) (IC50 = 14.3 nM) and ALK4, (IC50 = 58.5 nM) with no activity at ALK2, 3 and 6...

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  • Sildenafil citrate | PDE5 inhibitor
    Sildenafil citrate | PDE5 inhibitor
    $36.00
    Sildenafil citrate (171599-83-0) is a potent and selective phosphodiesterase (PDE5) inhibitor, IC50=4 nM).1-3 Clinically useful agent for male erectile disfunction4 and pulmonary hypertension5. References/Citations 1)...

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  • Focus Biomolecules cell signaling reagent supplier, Sivelestat | Leukocyte elastase inhibitor | CAS 127373-66-4
    Sivelestat | Leukocyte elastase inhibitor
    $50.00
    Sivelestat (127373-66-4) is a potent and selective leukocyte elastase inhibitor, IC50 = 44 nM1. Displays no activity at a variety of other proteases. Inhibits NF-κB activation2 and LTB4-induced neutrophil migration in...

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  • Suplatast tosilate | Immunomodulator
    Suplatast tosilate | Immunomodulator
    $55.00
    Suplatast tosilate (94055-79-2) is a potent immunoregulator that suppresses IgE production.1 Suppresses innate immunity by down-regulating TLR2, TLR4 and CD14 gene expression on splenocytes stimulated with LPS and TLR2/TLR4...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Terguride | Dopamine D2 agonist | CAS 37686-84-3
    Terguride | Dopamine D2 agonist
    $125.00
    Terguride (37686-84-3) is a semi-synthetic ergoline derivative which acts as a partial dopamine D2 agonist and 5HT2B/2C receptor antagonist. Displays antiparkinsonian effects in MPTP-treated cynomolgus monkeys1. Partial...

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  • Focus Biomolecules offers cell signaling reagent, Zafirlukast | HSP70 inhibitor, leukotriene antagonist | CAS 107753-78-6
    Zafirlukast | HSP70 inhibitor and leukotriene antagonist
    $28.00
    Zafirlukast (107753-78-6) is a competitive and selective leukotriene receptor antagonist1. Also inhibits calcium ionophore induced production of leukotriene B4 and leukotriene C4, which suggests a potential 5-LO inhibitory...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Zileutin | 5-LO inhibitor | CAS 111406-87-2
    Zileuton | 5-LO inhibitor
    $30.00
    Zileuton (111406-87-2) is a reversible inhibitor (IC50 = 500nM RBL-1 cells, 300nM rat PMNL cells) of 5-Lipoxygenase (5-LO).1 It also inhibited leukotriene B4 biosynthesis (IC50's = 400nM rat PMNL, 400nM human PMNL and 900nM...

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