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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Cilostamide | PDE3 inhibitor | CAS 68550-75-4
    Cilostamide (68550-75-4) is a selective inhibitor of phosphodiesterase-3 (PDE3). Displays limited selectivity for PDE3A versus PDE3B (IC50 = 27 and 50 nM)1,2. Blocks PKB/Akt signaling pathway downstream via inhibition of...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of ISO-1 | MIF antagonist | CAS 478336-92-4
    ISO-1 (478336-92-4) is an antagonist of macrophage migration inhibitory factor (MIF, a pro-inflammatory cytokine). Displays anti-inflammatory activity. Increases survival in severe sepsis1. Inhibits airway remodeling in...

  • Focus Biomolecules supplier, chemical structure of Montelukast sodium | Leukotriene & GPR17 antagonist | CAS 151767-02-1
    Montelukast sodium (151767-02-1) is a potent, selective CysLT1 receptor (leukotriene D4) antagonist (Ki = 0.18 nM).1,2 Displays anti-inflammatory and anti-asthmatic effects. Clinically useful agent for treatment of chronic...

  • Pranlukast | Leukotriene CysLT1 antagonist / GPR17 antagonist
    Pranlukast (103177-37-3)is a selective Leukotriene CysLT1 antagonist1 and has been used in the treatment of asthma2. Pranlukast is also an inhibitor of GPR173 (IC50’s = 10.5nM hGPR17, 31nM rGPR17) and is superior to...

  • Suplatast tosilate | Immunomodulator
    Suplatast tosilate (94055-79-2) is a potent immunoregulator that suppresses IgE production.1 Suppresses innate immunity by down-regulating TLR2, TLR4 and CD14 gene expression on splenocytes stimulated with LPS and TLR2/TLR4...

  • Focus Biomolecules offers cell signaling reagent, Zafirlukast | HSP70 inhibitor, leukotriene antagonist | CAS 107753-78-6
    Zafirlukast (107753-78-6) is a competitive and selective leukotriene receptor antagonist1. Also inhibits calcium ionophore induced production of leukotriene B4 and leukotriene C4, which suggests a potential 5-LO inhibitory...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Zileutin | 5-LO inhibitor | CAS 111406-87-2
    Zileuton (111406-87-2) is a reversible inhibitor (IC50 = 500nM RBL-1 cells, 300nM rat PMNL cells) of 5-Lipoxygenase (5-LO).1 It also inhibited leukotriene B4 biosynthesis (IC50's = 400nM rat PMNL, 400nM human PMNL and 900nM...

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