Fibrosis
Showing all 11 results
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Cancer
AG 1478 | EGFR kinase inhibitor
AG-1478 (175478-82-2; base) is a potent and selective inhibitor of the EGFR kinase (IC50 = 3 nM). Inhibits proliferation of a variety human cancer ...$50.00 – $150.00 Select options -
New Products
BI 749327 | Selective TRPC6 blocker
BI 749327 (2361241-23-6) is a potent (IC50 = 13 nM mouse TRPC6, 19 nM human TRPC6) and selective (85-fold over TRPC3, 42-fold over TRC7) orally ava...$80.00 – $300.00 Select options -
Bioinorganic chemistry
Bleomycin sulfate | Induces double strand DNA breaks
Bleomycin sulfate (9041-93-4) coordinates with metals producing reactive oxygen species which causes oxidative damage to DNA1 and RNA2. Induces dou...$75.00 – $250.00 Select options -
Approved Drugs
Fasudil HCl | ROCK inhibitor
Fasudil HCl (105628-07-7) is a Rho-associated kinase inhibitor (IC50 = 1.9 μM and 10.7 μM for Rho-associated kinase II and Rho-associated kinase re...$45.00 – $150.00 Select options -
New Products
GW788388 | TGF-ß receptor kinase inhibitor
GW788388 (452342-67-5) is a potent inhibitor of TGF-β receptor kinases ALK4, ALK5 (IC50=18 nM), ALK7, and TGFβRII, but not BMP type II receptor kin...$80.00 – $260.00 Select options -
Approved Drugs
Minocycline HCl | Neuroprotective/anti-inflammatory
Minocycline HCl (13614-98-7) displays antiapoptotic, anti-inflammatory1 activity. Prevents neuropathic pain in a rat sciatic nerve injury model.1 R...$38.00 – $152.00 Select options -
Cellular Stress
Monocrotaline | Induces pulmonary fibrosis
Monocrotaline (315-22-0) is a naturally occurring pyrrolizidine alkaloid used to create an animal model of pulmonary arterial hypertension (PAH). I...$49.00 – $105.00 Select options -
Antioxidants
Pirfenidone | Antifibrotic
Pirfenidone (53179-13-8) is an antifibrotic agent. Prevents lung fibrosis in bleomycin-induced animal models.1 Down-regulates bleomycin-induced ove...$30.00 – $100.00 Select options -
Diabetes
SB-216763 | GSK-3 inhibitor
SB-216763 (280744-09-4) is a potent and selective inhibitor of glycogen synthase kinase-1 (GSK-3) IC50=34.3 nM.1 Acts at the ATP-binding domain. Di...$50.00 – $190.00 Select options -
ALK
SB-525334 | ALK5 inhibitor
SB-525334 (356559-20-1) is a potent and selective inhibitor of the transforming growth factor beta 1 receptor, activin receptor-like kinase (ALK5) ...$60.00 – $220.00 Select options -
Approved Drugs
Suplatast tosilate | Immunomodulator
Suplatast tosilate (94055-79-2) is a potent immunoregulator that suppresses IgE production.1 Suppresses innate immunity by down-regulating TLR2, TL...$55.00 – $220.00 Select options
