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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of AG 1478 | EGFR kinase inhibitor | CAS 175178-82-2
    AG-1478 (175478-82-2; base) is a potent and selective inhibitor of the EGFR kinase (IC50 = 3 nM). Inhibits proliferation of a variety human cancer cell lines1,2. AG-1478 reduces pulmonary fibrosis in a rat model3. Cell...

  • Bleomycin sulfate | Induces double strand DNA breaks
    Bleomycin sulfate (9041-93-4) co ordinates with metals producing reactive oxygen species which causes oxidative damage to DNA1 and RNA2. Induces double-strand DNA damage3. Commonly used to induce lung fibrosis in animal...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Fasudil HCl | ROCK inhibitor | CAS 105628-07-7
    Fasudil HCl (105628-07-7) is a Rho-associated kinase inhibitor (IC50 = 1.9 μM and 10.7 μM for Rho-associated kinase II and Rho-associated kinase respectively)1. Inhibits other kinases including cyclic...

  • Minocycline HCl | Neuroprotective; antiapoptotic
    Minocycline HCl (13614-98-7) displays antiapoptotic, anti-inflammatory1 activity. Prevents neuropathic pain in a rat sciatic nerve injury model1. Reduces MMP-9 activity2. Attenuates disease severity in mouse models of...

  • Monocrotaline | Induces pulmonary fibrosis
    Monocrotaline (315-22-0) is a naturally occurring pyrrolizidine alkaloid used to create an animal model of pulmonary arterial hypertension (PAH). It can mimic several important aspects of human PAH including vascular...

  • Pirfenidone | Antifibrotic
    Pirfenidone (53179-13-8) is an antifibrotic agent. Prevents lung fibrosis in bleomycin-induced animal models.1 Down-regulates bleomycin-induced overexpression of lung procollagen I and III genes.2 Up-regulates RGS2...

  • SB-216763 | GSK-3 inhibitor
    SB-216763 (280744-09-4) is a potent and selective inhibitor of glycogen synthase kinase-1 (GSK-3) IC50=34.3 nM1. Acts at the ATP-binding domain. Displays protective effects in lung fibrosis mouse model2. Displays...

  • SB-525334 | ALK5 (TGFbeta R1) inhibitor
    SB-525334 (356559-20-1) is a potent and selective inhibitor of the transforming growth factor beta 1 receptor, activin receptor-like kinase (ALK5) (IC50 = 14.3 nM) and ALK4, (IC50 = 58.5 nM) with no activity at ALK2, 3 and 6...

  • Suplatast tosilate | Immunomodulator
    Suplatast tosilate (94055-79-2) is a potent immunoregulator that suppresses IgE production.1 Suppresses innate immunity by down-regulating TLR2, TLR4 and CD14 gene expression on splenocytes stimulated with LPS and TLR2/TLR4...

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