Ro 31-6045 (113963-68-1) is a bis indolylmaleimide derivative that is a potent inhibitor of the mitogen-stimulated protein kinase p70 (S6K) acting independently of its upstream activator mTOR.1 Does not inhibit PKC (at concentrations <100 μM) and therefore may be used as a negative control for bisindolylmaleimide PKC inhibitors2 such as GF 109203X3 and other structurally related inhibitors4.
1) Marmy-Conus et al. (2002), Ro 31-6045, the inactive analogue of the protein kinase C inhibitor Ro 31-8220, blocks in vivo activation of p70(s6k)/p85(s6k): implications for the analysis of S6K signalling; FEBS Lett., 519 135
2) Harmon et al. (1997), Bisindolylmaleimide protein-kinase C inhibitors delay in the decline in DNA synthesis in mouse hair follicle organ cultures; Skin Pharmacol., 10 71
3) Toullec et al. (1991), The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C; J. Biol. Chem., 266 15771
4) Davis et al. (1992), Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides; J. Med. Chem., 35 177