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Ro 31-6045 | p70 S6 Kinase inhibitor

Ro 31-6045 (113963-68-1) is a bis indolylmaleimide derivative that is a potent inhibitor of the mitogen-stimulated protein kinase p70 (S6K) acting independently of its upstream activator mTOR.1 Does not inhibit PKC (at concentrations <100 μM) and therefore may be used as a negative control for bisindolylmaleimide PKC inhibitors2 such as GF 109203X3 and other structurally related inhibitors4.


1) Marmy-Conus et al. (2002), Ro 31-6045, the inactive analogue of the protein kinase C inhibitor Ro 31-8220, blocks in vivo activation of p70(s6k)/p85(s6k): implications for the analysis of S6K signalling; FEBS Lett., 519 135
2) Harmon et al. (1997), Bisindolylmaleimide protein-kinase C inhibitors delay in the decline in DNA synthesis in mouse hair follicle organ cultures; Skin Pharmacol., 10 71
3) Toullec et al. (1991), The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C; J. Biol. Chem., 266 15771
4) Davis et al. (1992), Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides; J. Med. Chem., 35 177

Focus Biomolecules cell signaling reagent supplier, chemical structure Ro 31-6045 | MAP Kinase inhibitor | CAS 113963-68-1

Catalog#  10-1603-0001

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Catalog Number:
MAP Kinase inhibitor
Chemical Name:
Alternate Names:
Bisindolylmaleimide V; BIM V
Molecular Weight:
Molecular Formula:
Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 9 mg/ml)
Physical Properties:
Orange solid
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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