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  • (R)-(+)-Etomoxir Na | Carnitine palmitoyltransferase inhibitor
    (R)-(+)-Etomoxir Na | Carnitine palmitoyltransferase inhibitor
    $70.00
    Etomoxir (828934-41-4) is an irreversible inhibitor of mitochondrial carnitine palmitoyl transferase 1 (CPT1).1 It is widely used to study fatty acid oxidation. Etomoxir has been investigated as a therapeutic agent for heart...

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  • Focus Biomolecules cell signaling reagent supplier, structure of 3-Aminobenzamide | PARP inhibitor | CAS 3544-24-9
    3-Aminobenzamide | PARP inhibitor
    $50.00
    3-Aminobenzamide (3544-24-9) inhibits endogenous poly-ADP-ribosyltransferases1. Inhibits nitric oxide-induced apoptosis but not differentiation in HL-60 cells2. Inhibits stress-induced apoptosis3. 3-Aminobenzamide has been...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of AI-1 | Nrf2 activator | CAS 75483-04-4
    AI-1 | Nrf2 activator
    $70.00
    AI-1 (75483-04-4) is a novel antioxidant response element (ARE) activator which activates Nrf2 by covalently modifying Keap1 (Kelch-like ECH-associated protein 1) a negative regulator of Nrf2. Modification of Cys151 of Keap1...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of AI-3 | ARE activator | CAS 882288-28-0
    AI-3 | ARE activator
    $75.00
    AI-3 (882288-28-0) is an activator of antioxidant response element (ARE) which induces cytoprotective genes in human cells. It alkylates Keap1 at Cys151 and is reactive toward additional cysteines at higher concentrations...

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  • Focus Biomolecules cell signaling tech supplier, chemical structure Ambroxol HCl | Free radical scavenger | CAS 18683-91-5
    Ambroxol HCl | Free radical scavenger
    $50.00
    Ambroxol HCl (18683-91-5) is a radical scavenger with anti-inflammatory activity. Blocks the generation of reactive oxygen species by bronchoalveolar lavage cells, inhibits doxorubicin-induced lipid peroxidation (70 mg/kg in...

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  • Focus Biomolecules cell signaling reagent supplier, structure of Apigenin | Protein kinase inhibitor | CAS 520-36-5
    Apigenin | Protein kinase inhibitor
    $36.00
    Apigenin (520-36-5) is a plant flavonoid with antioxidant properties. It has been reported to have myriad effects on biochemical pathways including kinase inhibition (CK2, PKC, ERK)1-3, CYP2CP inhibition4, inhibition of...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure Artesunate | Kills cancer stem cells | CAS 88495-63-0
    Artesunate | Kills cancer stem cells / Depolarizes mitochondria
    $45.00
    Artesunate (88495-63-0) is a semisynthetic derivative of the natural product artemisinin which is clinically useful for treatment of malaria and other parasitic diseases. Depolarizes mitochondrial membrane via generation of...

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  • Auraptene | Neuroprotective / Neuritogenic agent
    Auraptene | Neuroprotective / Neuritogenic agent
    $30.00
    Auraptene (495-02-3) is a bioactive terpenoid occurring in a variety of citrus fruits and possessing therapeutic potential.1   Displays neuritogenic activity2 and neuroprotective effects via suppression of...

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  • Bakuchiol | Antioxidant
    Bakuchiol | Antioxidant
    $65.00
    Bakuchiol (10309-37-2) is a natural terpenoid antioxidant.1 Inhibits oxidative stress-induced decrease in mitochondrial membrane potential and associated release of pro-apoptotic factors.2 Protects against acute lung injury...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of bis-BHT | Antioxidant-phenolic | CAS 118-82-1
    bis-BHT | Antioxidant-phenolic
    $35.00
    bis-BHT (118-82-1) is a potent antioxidant. Cell permeable. References/Citations1) Amorati et al. (2003), Antioxidant activity of 0-bisphenols: the role of intramolecular hydrogen bonding; J. Org. Chem. 68...

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  • Focus Biomolecules supplier, chemical structure of Bleomycin sulfate | Induces double strand DNA breaks | CAS 9041-93-4
    Bleomycin sulfate | Induces double strand DNA breaks
    $90.00
    Bleomycin sulfate (9041-93-4) coordinates with metals producing reactive oxygen species which causes oxidative damage to DNA1 and RNA2. Induces double-strand DNA damage.3 Commonly used to induce lung fibrosis in animal...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of CAPE | Inhibits NFkB activation | CAS 104594-70-9
    CAPE | Inhibits NFkB activation
    $30.00
    CAPE (104594-70-9) is an antioxidant that inhibits NFκB activation and the growth of transformed cells. CAPE inhibits lipid peroxidation and displays antiinflammatory activity. Cell permeable. References/Citations1)...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Carnosic acid | Antioxidant | CAS 3650-09-7
    Carnosic acid | Antioxidant
    $40.00
    Carnosic acid (3650-09-7) is an antioxidant and free radical scavenger. Increases cellular levels of glutathione (GSH) and prevents 6-hydroxydopamine-induced cell death in SH-SY5Y cells1. Carnosic acid-stimulation of GSH...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Celastrol | Proteasome inhibitor | CAS 34157-83-0
    Celastrol | Proteasome inhibitor
    $50.00
    Celastrol (34157-83-0) displays potent antioxidant and anti-inflammatory activity. Inhibits NFkB (IC50=270 nM).  It induces heat shock response and cytoprotection in various cells. Inhibits 20S proteasome chymotrypsin...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of CHS-828 | NAMPT inhibitor | CAS 200484-11-3
    CHS-828 | NAMPT inhibitor
    $50.00
    CHS-828 (200484-11-3) is a potent and selective inhibitor of nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in the biosynthesis of NAD, which may be used to deplete cells of NAD.1 Displays potent...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of CYPMPO | Spin trap | CAS 934182-09-9
    CYPMPO | Spin trap
    $40.00
    CYPMPO (934182-09-9) is a free radical spin-trap with hydroxyl and superoxide free radical trapping capabilities similar to DEPMPO (Cat.# 10-4502). Better solubility and increased half-life in aqueous buffers can give CYPMPO...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Decylubiquinone | MPTP inhibitor | CAS 55486-00-5
    Decylubiquinone | MPTP inhibitor
    $48.00
    Decylubiquinone (55486-00-5) inhibits the Ca2+ dependent mitochondrial permeability transition pore (MPTP) without inhibiting respiration.1 Maximum effect on Ca2+ retention capacity of rat liver mitochondria at 100 μM...

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  • Deferiprone | Iron Chelator
    Deferiprone | Iron Chelator
    $20.00
    Deferiprone (30652-11-0) is a clinically useful iron chelator.1 It attenuated blood-brain-barrier breakdown and brain mitochondrial dysfunction in rats with chronic iron-overload.2 Iron chelation therapy has been suggested...

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  • Focus Biomolecules cell signaling tech supplier, chemical structure of Dehydrozingerone | Glutathione sponge | CAS 1080-12-2
    Dehydrozingerone | Glutathione sponge
    $35.00
    Dehydrozingerone (1080-12-2) is a structural half analog of curcumin (Cat.# 10-1243) and is isolated from ginger rhizomes. Dehydrozingerone displays antioxidant, antibacterial and antifungal properties.1 It has also been...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of DEPMPO | Spin trap | CAS 157230-67-6
    DEPMPO | Spin trap
    $95.00
    DEPMPO (157230-67-6) is a spin trap capable of detecting oxygen, nitrogen, sulfur and carbon-centered free radicials both in vitro and in vivo. DEPMPO is useful for distinguishing between superoxide-dependent pathways of...

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