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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of AI-1 | Nrf2 activator | CAS 75483-04-4
    AI-1 (75483-04-4) is a novel antioxidant response element (ARE) activator which activates Nrf2 by covalently modifying Keap1 (Kelch-like ECH-associated protein 1) a negative regulator of Nrf2. Modification of Cys151 of Keap1...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of AI-3 | ARE activator | CAS 882288-28-0
    AI-3 (882288-28-0) is an activator of antioxidant response element (ARE) which induces cytoprotective genes in human cells. It alkylates Keap1 at Cys151 and is reactive toward additional cysteines at higher concentrations...

  • Ambroxol HCl | Free radical scavenger
    Ambroxol HCl (18683-91-5) is a radical scavenger with anti-inflammatory activity. Blocks the generation of reactive oxygen species by bronchoalveolar lavage cells, inhibits doxorubicin-induced lipid peroxidation (70 mg/kg in...

  • Focus Biomolecules cell signaling reagent supplier, structure of Apigenin | Protein kinase inhibitor | CAS 520-36-5
    Apigenin (520-36-5) is a plant flavonoid with antioxidant properties. It has been reported to have myriad effects on biochemical pathways including kinase inhibition (CK2, PKC, ERK)1-3, CYP2CP inhibition4, inhibition of...

  • Bakuchiol | Antioxidant
    Bakuchiol (10309-37-2) is a natural terpenoid antioxidant.1 Inhibits oxidative stress-induced decrease in mitochondrial membrane potential and associated release of pro-apoptotic factors.2 Protects against acute lung injury...

  • bis-BHT | Antioxidant-phenolic
    bis-BHT (118-82-1) is a potent antioxidant. Cell permeable. References/Citations1) Amorati et al. (2003), Antioxidant activity of 0-bisphenols: the role of intramolecular hydrogen bonding; J. Org. Chem. 68...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of CAPE | Inhibits NFkB activation | CAS 104594-70-9
    CAPE (104594-70-9) is an antioxidant that inhibits NFκB activation and the growth of transformed cells. CAPE inhibits lipid peroxidation and displays antiinflammatory activity. Cell permeable. References/Citations1)...

  • Carnosic acid | Antioxidant
    Carnosic acid (3650-09-7) is an antioxidant and free radical scavenger. Increases cellular levels of glutathione (GSH) and prevents 6-hydroxydopamine-induced cell death in SH-SY5Y cells1. Carnosic acid-stimulation of GSH...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Celastrol | Proteasome inhibitor | CAS 34157-83-0
    Celastrol (34157-83-0) displays potent antioxidant and anti-inflammatory activity. Inhibits NFkB (IC50=270 nM).  It induces heat shock response and cytoprotection in various cells. Inhibits 20S proteasome chymotrypsin...

  • Decylubiquinone | MPTP inhibitor
    Decylubiquinone (55486-00-5) inhibits the Ca2+ dependent mitochondrial permeability transition pore (MPTP) without inhibiting respiration.1 Maximum effect on Ca2+ retention capacity of rat liver mitochondria at 100 μM...

  • Dehydrozingerone | Glutathione sponge
    Dehydrozingerone (1080-12-2) is a structural half analog of curcumin (Cat.# 10-1243) and is isolated from ginger rhizomes. Dehydrozingerone displays antioxidant, antibacterial and antifungal properties.1 It has also been...

  • Ebselen | Glutathione peroxidase mimic
    Ebselen (60940-34-3) is a novel nontoxic selenium-containing multifunctional antioxidant and anti-inflammatory agent.1 Displays protective effects in reperfusion injury and stroke.2 Ebselen is an excellent...

  • Entacapone | COMT inhibitor - anti-Parkinsons
    Entacapone (130929-57-6) is a potent catechol O-methyltransferase (COMT) inhibitor (IC50 = 14.3, 20.1 and 73.3 nM for rat liver soluble COMT, total COMT and membrane-bound COMT respectively).1 Increases bioavailability of...

  • Focus Biomolecules supplier, chemical structure of Ferrostatin-1 | Ferroptosis inhibitor | CAS 347174-05-4
    Ferrostatin-1 (347174-05-4) inhibits ferroptosis (EC50=60 nM), an iron-dependent form of nonapoptotic cell death.1 Potent inhibitor of ferroptosis in cancer cells and glutamate-induced cell death in organotypic rat...

  • Focus Biomolecules supplier, chemical structure of Hinokitiol | Iron Chelator antioxidant | CAS 499-44-5
    Hinokitiol (499-44-5) is a potent metal chelator that induces differentiation and apoptosis in teratocarcinoma F9 cells.1 It acts as a reversible inhibitor of platelet-type 12-lipoxygenase (IC50 = 100 nM).2 Hinokitiol is...

  • Focus Biomolecules cell signaling tech supplier, Idebenone | Quinone antioxidant, free radical scavenger | CAS 58186-27-9
    Idebenone (58186-27-9) is an analog of coenzyme Q10 which acts as an antioxidant1. Protects mitochondrial membranes against lipid peroxidation and blocks glutamate neurotoxicity in vitro and in vivo2. Increases NGF...

  • L-Ergothioneine | Antioxidant - endogenous
    Naturally occurring ubiquitous antioxidant which is found in many cells at concentrations up to 2 mM.1 Rescues PC12 cells from b-amyloid-induced apoptotic cell death.2 Protects against cisplatin-induced neuronal...

  • MCI-186 | Antioxidant-nonphenolic
    MCI-186 (89-25-8), also known as edaravone,  is an antioxidant free radical scavenger used as a neuroprotective agent following acute brain ischemia and subsequent cerebral infarction.1,2 MCI-186 also protects against...

  • Mito-TEMPO | Mitochondria targeted antioxidant
    Mito-TEMPO (1334850-99-5) is a mitochondria-targeted antioxidant. Partially prevents mitochondrial permeability transition pore opening, necrosis and mitochondrial apoptosis after ATP depletion recovery.1 Resolves...

  • Focus Biomolecules supplier, chemical structure of Mitoquinone | Mitochondria-targeted antioxidant | CAS 444890-40-9
    Mitoquinone (444890-40-9) is a mitochondria-targeted antioxidant. Displays cardio- and neuroprotective effects.1 Displays beneficial effects in mouse models of Alzheimer's disease.2 Mitoquinone protects pancreatic...

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