Deferiprone | Iron Chelator
Deferiprone (30652-11-0) is a clinically useful iron chelator.1 It attenuated blood-brain-barrier breakdown and brain mitochondrial dysfunction in rats with chronic iron-overload.2 Iron chelation therapy has been suggested as a possible therapy for Alzheimer’s Disease.3
References/Citations:
1) Hider and Hoffbrand (2018), The Role of Deferiprone in Iron Chelation; N. Engl. J. Med., 379 2140
2) Sripetchwandee et al. (2016), A combination of an iron chelator with an antioxidant effectively diminishes the dendritic loss, tau-hyperphosphorylation, amyloid-β accumulation and brain mitochondrial dynamic disruption in rats with chronic iron-overload., Neuroscience 332 191
3) Liu et al. (2018), Iron and Alzheimer’s Disease: From Pathogenesis to Therapeutic Implications; Front. Neurosci, 12 632
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Deferiprone (30652-11-0) is a clinically useful iron chelator.1 It attenuated blood-brain-barrier breakdown and brain mitochondrial dysfunction in rats with chronic iron-overload.2 Iron chelation therapy has been suggested as a possible therapy for Alzheimer’s Disease.3
References/Citations:
1) Hider and Hoffbrand (2018), The Role of Deferiprone in Iron Chelation; N. Engl. J. Med., 379 2140
2) Sripetchwandee et al. (2016), A combination of an iron chelator with an antioxidant effectively diminishes the dendritic loss, tau-hyperphosphorylation, amyloid-β accumulation and brain mitochondrial dynamic disruption in rats with chronic iron-overload., Neuroscience 332 191
3) Liu et al. (2018), Iron and Alzheimer’s Disease: From Pathogenesis to Therapeutic Implications; Front. Neurosci, 12 632
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Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21
Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21
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