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Inducers and pro oxidants

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  • (R)-(+)-Etomoxir Na | Carnitine palmitoyltransferase inhibitor
    Etomoxir (828934-41-4) is an irreversible inhibitor of mitochondrial carnitine palmitoyl transferase 1 (CPT1).1 It is widely used to study fatty acid oxidation. Etomoxir has been investigated as a therapeutic agent for heart...

  • Artesunate | Kills cancer stem cells / Depolarizes mitochondria
    Artesunate (88495-63-0) is a semisynthetic derivative of the natural product artemisinin which is clinically useful for treatment of malaria and other parasitic diseases. Depolarizes mitochondrial membrane via generation of...

  • CHS-828 | NAMPT inhibitor
    CHS-828 (200484-11-3) is a potent and selective inhibitor of nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in the biosynthesis of NAD, which may be used to deplete cells of NAD.1 Displays potent...

  • DMNQ | Induces ROS generation
    DMNQ (6956-96-3) is a non-alkylating redox cycling quinone. A useful tool for studying reactive oxidant species and oxidative stress. Cellular effects are dependent on concentration and cell type. References/Citations1)...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of HQNO | NADH oxidase inhibitor | CAS 341-88-8
    HQNO (341-88-8) is a naturally occurring antagonist of dihydrostreptomycin. Potent inhibitor of the respiratory chain binding to the mitochondrial cytochrome b protein. HQNO inhibits NADH oxidase (NADH) and Na+-dependent...

  • Patulin | Oxidative- and ER-stress inducer
    Patulin (149-29-1) is a mycotoxin found in contaminated fruits.  Increases ROS generation and oxidative stress in cells which is mediated by p53.1 Displays cytotoxic effects on a variety of cell lines.2 Causes damage to...

  • Piperlongumine | Glutathione sponge / Increases ROS levels
    Piperlongumine (20069-09-4) elevates cellular levels of reactive oxygen species selectively in cancer cell lines1. Irreversible glutathionylation leading to depletion of cellular glutathione is associated with its cellular...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Pyocyanin | ROS generator | CAS 85-66-5
    Pyocyanine (85-66-5), a redox-active phenazine produced by P. aeruginosa and other pathogens, is an electron receptor, which stimulates redox cycling in bacteria as well as in a variety of human cell lines. It enhances...

  • R162 | Glutamate dehydrogenase 1 inhibitor
    R162 (64302-87-0) is a selective inhibitor of glutamate dehydrogenase 1 (GDH1), a commonly upregulated enzyme in human cancers (Ki = 28.6 µM).  It does not inhibit the activity of other NADPH enzymes such as...

  • TTFA | Mitochondrial Complex II inhibitor
    TTFA (326-91-0) blocks the respiratory chain complex II causing inhibition of mitochondrial respiration.  Respiratory chain complex II inhibition is caused via binding of TTFA to two ubiquinone binding sites, Qp...

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