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Metal Chelators

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  • Focus Biomolecules supplier, chemical structure of Bleomycin sulfate | Induces double strand DNA breaks | CAS 9041-93-4
    Bleomycin sulfate (9041-93-4) coordinates with metals producing reactive oxygen species which causes oxidative damage to DNA1 and RNA2. Induces double-strand DNA damage.3 Commonly used to induce lung fibrosis in animal...

  • Deferiprone | Iron Chelator
    Deferiprone (30652-11-0) is a clinically useful iron chelator.1 It attenuated blood-brain-barrier breakdown and brain mitochondrial dysfunction in rats with chronic iron-overload.2 Iron chelation therapy has been suggested...

  • Focus Biomolecules supplier, chemical structure of Hinokitiol | Iron Chelator antioxidant | CAS 499-44-5
    Hinokitiol (499-44-5) is a potent metal chelator that induces differentiation and apoptosis in teratocarcinoma F9 cells.1 It acts as a reversible inhibitor of platelet-type 12-lipoxygenase (IC50 = 100 nM).2 Hinokitiol is...

  • Focus Biomolecules cell signaling reagent supplier, structure of TPEN | Intracellular Zn2+ chelator | CAS 168858-02-9
    TPEN (16858-02-9) is a cell permeable metal chelator. Frequently used to study effects of zinc depletion on cellular processes.1,2 References/Citations1) Chimienti et al. (2001) Role of cellular zinc in programmed cell...