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Signaling Pathways

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  • AE 51310 | OPN4/Melanopsin antagonist
    $50.00
    AE 51310 (433966-92-8) is a potent antagonist of the GPCR OPN4/melanopsin (Ki = 0.096 nM human OPN4).1 OPN4 regulates circadian rhythms, pupil functions, melatonin expression, cognition, and sleep. OPN4 has been found to...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of AG-490 | JAK-2 inhibitor | CAS 133550-30-8
    $50.00
    AG-490 (133550-30-8) is a potent inhibitor of the JAK-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells, which abundantly express JAK-2, AG-490 dose-dependently blocked cell growth, induced apoptosis and...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of AICAR | AMPK activator | CAS 2627-69-2
    $30.00
    Activates AMP-activated protein kinase (AMPK). Promotes ligand-independent activation of the insulin receptor.1 Promotes skeletal muscle autophagy via activation of FoxO3a.2 Controls smooth muscle cell hyperproliferation in...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Anisomycin | Anoikis sensitizer | CAS 22862-76-6
    $35.00
    Anisomycin (22862-76-6) activates JNK/SAPKs and reduces c-fos and c-jun. Protein synthesis inhibitor. Anisomycin induces apoptosis and sensitizes cells to anoikis. Cell permeable. References/Citations1) Hazzalin et al...

  • Baricitinib | JAK 1/2 inhibitor
    $50.00
    Baricitinib (1187594-09-7), approved by the FDA for two inflammatory disorders, rheumatoid arthritis and alopecia areata, selectively inhibits Janus kinase 1 (IC50 = 5.9 nM) and 2 (5.7 nM), over 3 (0.56 µM).1 It...

  • Buparlisib (CAS# 944396-07-0) chemical structure Focus Biomolecules
    $70.00
    Buparlisib is potent pan-Class I PI3-kinase inhibitor (IC50’s: p110a = 52 nM, p110b = 166 nM, p110d = 116 nM. P110g = 262 nM).1,2 It inhibited microtubule dynamics at in vitro concentrations >1µM and doses...

  • Focus Biomolecules supplier, chemical structure of CUR 61414 | Hedgehog pathway antagonist | CAS 334998-26-6
    $90.00
    CUR 61414 (334998-26-6) is a novel Hedgehog signaling pathway inhibitor (IC50=100-200 nM). Selectively binds to Smo but not other GPCRs. CUR 61414 blocks the formation of and induces the regression of basaloid lesions in...

  • Focus Biomolecules cell signaling reagent supplier, structure Cyclopamine | Inhibits hedgehog signaling | CAS 4449-51-8
    $45.00
    Cyclopamine (4449-51-8) is a naturally occurring steroidal alkaloid with teratogenic activity. Blocks sonic hedgehog signaling by binding to smoothened. Antitumor activity. Cell Permeable. References/Citations1) Watkins et...

  • Focus Biomolecules supplier, chemical structure of Cytochalasin D | Disrupts actin filaments | CAS 22144-77-0
    $63.00
    Cytochalasin D (22144-77-0) is a potent inhibitor of actin polymerization which also causes the disruption of actin filaments. More potent that cytochalasin B (10-fold) and does not inhibit monosaccharide transport across...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of DAPT | gamma-secretase inhibitor | CAS 208255-80-5
    $60.00
    DAPT (208255-80-5)is an inhibitor of γ-secretase (IC50 in human primary neurons = 115 nM for total Aβ or 200 nM for Aβ42 specifically)1. Oral administration of DAPT has been shown to reduce levels of Aβ...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Deguelin | Akt inhibitor | CAS 522-17-8
    $70.00
    Deguelin (522-17-8) inhibits Akt.1,2 Induces apoptosis in a variety of cells.2,3 Displays cancer chemopreventive activity.4 Deguelin is cell permeable and active in vivo. References/Citations1) Chun et al...

  • Focus Biomolecules reagent supplier, chemical structure of Destruxin B | Apoptosis inducer; anticancer agent | CAS 2503-26-6
    $125.00
    Destruxin B (2503-26-6) is a cyclic depsipeptide produced by various species of fungi.1 Induces apoptosis in human nonsmall cell lung cancer cells.2 Displays selective cytotoxic effects on human oral cancer cell lines.3...

  • Emetine hydrochloride | Protein synthesis inhibitor
    $50.00
    Emetine hydrochloride (483-18-1) is one of the active ingredients of ipecac root extract, used as an emetic.1 Induces apoptosis in breast cancer cells via inhibition of Wnt/β-catenin signaling.2 Inhibits Zika and Ebola...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Enzastaurin | PKC inhibitor | CAS 170364-57-5
    $60.00
    Enzastaurin (170364-57-5) is a potent and selective PKCβ inhibitor.  IC50 = 6, 39, 83 and 110 nM, for PKCβ, PKCα, PKCγ and PKCε respectively.1 Induces apoptosis in multiple myeloma cell...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Everolimus | mTOR inhibitor | CAS 159351-69-6
    $50.00
    Everolimus (159351-69-6) is a semisynthetic analog of rapamycin (Cat.# 10-1104) with potent immunosuppressive activity.1 Inhibits mTOR.2 Everolimus is a clinically useful immunosuppressant.3 References/Citations1)...

  • Focus Biomolecules cell signaling reagent supplier, structure of FH-535 | Wnt/beta-cantenin inhibitor | CAS 108409-83-2
    $50.00
    FH-535 (108409-83-2) suppresses Wnt/β-catenin signaling. It antagonizes PPARγ and PPARδ ligand-dependent activation which is mediated by inhibition of recruitment of the coactivators β-catenin and GRIP1...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of FLI-06 | Notch pathway inhibitor | CAS 313967-18-9
    $80.00
    FLI-06 (313967-18-9) was discovered in a screen designed to monitor the trafficking and processing of a ligand-independent Notch-enhanced GFP reporter. It disrupts the Golgi apparatus in a manner distinct from that of...

  • Focus Biomolecules supplier, chemical structure of Forskolin | Adenylate cyclase activator | CAS 66575-29-9
    $60.00
    Forskolin (66575-29-9) is a widely used adenylate cyclase activator.1 Forskolin also is a positive inotropic agent, vasodilator and induces platelet activation among other activities.2-5 References/Citations1) Awad et al...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of GDC-0941 | pan-PI3K inhibitor | CAS 957054-30-7
    $58.00
    GDC-0941 (957054-30-7) is a potent and selective inhibitor of class I phosphatidylinositol-3-kinases (PI3K) with significant antitumor activity – IC50’s: PI3Kα = 3nM, PI3Kβ = 33 nM, PI3Kδ = 3 nM,...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of GW-5074 | c-Raf1 inhibitor | CAS 220904-83-6
    $50.00
    GW-5074 (220904-83-6) is a potent inhibitor of cRAF1 kinase (IC50 = 9 nM). Displays 100-fold selectivity for cRAF1 over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm. GW-5074 displays neuroprotective effects In...