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  • Focus Biomolecules supplier, chemical structure of CUR 61414 | Hedgehog pathway antagonist | CAS 334998-26-6
    CUR 61414 (334998-26-6) is a novel Hedgehog signaling pathway inhibitor (IC50=100-200 nM). Selectively binds to Smo but not other GPCRs. CUR 61414 blocks the formation of and induces the regression of basaloid lesions in...

  • Focus Biomolecules cell signaling reagent supplier, structure Cyclopamine | Inhibits hedgehog signaling | CAS 4449-51-8
    Cyclopamine (4449-51-8) is a naturally occurring steroidal alkaloid with teratogenic activity. Blocks sonic hedgehog signaling by binding to smoothened. Antitumor activity. Cell Permeable. References/Citations1) Watkins et...

  • HPI-1 | Hedgehog pathway inhibitor
    HPI-1 (599150-20-6) is a Hedgehog pathway inhibitor acting downstream of Smo and independently of PKA, PI3K and MAPK. It can suppress Hh pathway activation induced by loss of Su(fu) or Gli overexpression. HPI-1 inhibits both...

  • Itraconazole | Autophagy inducer / Inhibits glioblastoma growth
    Itraconazole (84625-61-6) inhibits the conversion of lanosterol to ergosterol via inhibition of the 14-α demethylase, a cytochrome P-450 enzyme.1 Clinically useful antifungal agent. It inhibits the proliferation of...

  • Jervine | Hedgehog pathway
    Jervine (469-59-0) is an inhibitor of Hedgehog signaling (IC50 = 0.5-0.7 μM). Binds directly to Smoothened (Smo)1. Inhibits the response of target tissues to Sonic hedgehog signaling2. Jervine induces COX-2 overexpression...

  • Purmorphamine | Smoothened activator
    Purmorphamine induces osteogenesis in multipotent mesenchymal progenitor cells via activation of hedgehog signaling.1,2 Activation of hedgehog is achieved via direct targeting of Smoothened.3 Purmorphamine has also been used...

  • SAG | Smoothened agonist
    SAG (912545-86-9) is a smoothened agonist which bind directly to SMO and can block SMO inhibition by cyclopamine (Cat.# 10-1082). The conformation of SMO is altered by SAG binding which results in the accumulation of SMO in...

  • Salinomycin Na | Cancer stem cell inhibitor
    Salinomycin Na (55721-31-8) is a polyether ionophore with antibiotic and anti-cancer properties. It induces cell death in some types of cancer cells such as breast, lung, gastric cancer, leukemia and osteosarcoma...

  • Synaptamide | 162758-94-3 |Structure | Supplier
    Synaptamide (162758-94-3) is an anandamide-like lipid mediator produced from DHA in the brain. Stimulates neurite growth, synaptogenesis and glutamatergic synaptic activity in developing hippocampal neurons at 10-100 nM.1...

  • Veratramine | 60-70-8 | Structure | Supplier
    Veratramine (60-70-8) is a teratogenic steroidal alkaloid found in the corn lily (Veratrum sp.).1,2 It is an analog of cyclopamine which can inhibit the hedgehog signaling pathway-dependent proliferation in NIH/3T3 cells at...

  • Focus Biomolecules supplier, chemical structure of Vismodegib | Sonic Hedgehog signaling pathway inhibitor | CAS 879085-55-9
    A potent and selective Hedgehog (Hh) pathway signaling inhibitor antagonizing SMO with a Ki of 1.3 nM).1 Alters intracellular Ca2+ homeostasis and inhibits growth of cisplatin-resistant lung cancer cells.2  Inhibits two...

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