IWR-1 endo | Wnt signaling inhibitor
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $50.00 | ||
| 25 mg | $200.00 |
IWR-1 endo (1127442-82-3) is a potent inhibitor of Wnt signaling (IC50=180 nM).1 Inhibits zebrafish tailfin regeneration (0.5 mM).2 Acts via inhibition of tankyrase and attenuates Wnt/β-catenin signaling in cancer stem-like cells.3 Promotes self-renewal and maintains pluripotency of human embryonic stem cells.4 Promotes differentiation of pluripotent stem cells into cardiomyocytes.5
References/Citations:
1) Chen et al. (2009), Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer; Nature Chem. Biol., 5 100
2) Lu et al. (2009), Structure-activity Relationship Studies of Small-Molecule Inhibitors of Wnt Response; Bioorg. Med. Chem. Lett., 19 3825
3) Martins-Neves et al. (2018), IWR-1, a tankyrase inhibitor, attenuates Wnt/ß-catenin signaling in cancer stem-like cells and inhibits in vivo the growth of subcutaneous human osteosarcoma xenograft; Cancer Lett., 414 1
4) Kim et al. (2013), Modulations of ß-catenin function maintains mouse epiblast stem cell and human embryonic stem cell self-renewal; Nat. Commun., 4 4403
5) Ren et al. (2011), Small Molecule Wnt Inhibitors Enhance the Efficiency of BMP-4-directed Cardiac Differentiation of Human Pluripotent Stem Cells; J. Mol. Cell. Cardiol., 51 280
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
IWR-1 endo (1127442-82-3) is a potent inhibitor of Wnt signaling (IC50=180 nM).1 Inhibits zebrafish tailfin regeneration (0.5 mM).2 Acts via inhibition of tankyrase and attenuates Wnt/β-catenin signaling in cancer stem-like cells.3 Promotes self-renewal and maintains pluripotency of human embryonic stem cells.4 Promotes differentiation of pluripotent stem cells into cardiomyocytes.5
References/Citations:
1) Chen et al. (2009), Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer; Nature Chem. Biol., 5 100
2) Lu et al. (2009), Structure-activity Relationship Studies of Small-Molecule Inhibitors of Wnt Response; Bioorg. Med. Chem. Lett., 19 3825
3) Martins-Neves et al. (2018), IWR-1, a tankyrase inhibitor, attenuates Wnt/ß-catenin signaling in cancer stem-like cells and inhibits in vivo the growth of subcutaneous human osteosarcoma xenograft; Cancer Lett., 414 1
4) Kim et al. (2013), Modulations of ß-catenin function maintains mouse epiblast stem cell and human embryonic stem cell self-renewal; Nat. Commun., 4 4403
5) Ren et al. (2011), Small Molecule Wnt Inhibitors Enhance the Efficiency of BMP-4-directed Cardiac Differentiation of Human Pluripotent Stem Cells; J. Mol. Cell. Cardiol., 51 280
Related products
-
AG-1296 | PDGFR kinase inhibitor
From $60.00CAS:146535-11-7Catalog Number:10-1087Activity:PDGFR kinase inhibitorChemical Name:6,7-Dimethoxy-3-phenylquinoxalineMolecular Weight:266.3Molecular Formula:C16H14N2O2Solubility:Soluble in DMSO.Physical Properties:Yellow solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT -
Imatinib mesylate | BCR-ABL inhibitor
From $30.00CAS:220127-57-1Catalog Number:10-1060Activity:BCR-ABL inhibitorAlternate Names:GleevecChemical Name:4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide methanesulfonateMolecular Weight:589.73Molecular Formula:C29H31N7O CH3SO3HSolubility:Soluble in DMSO (up to 50 mg/ml) or in Water (up to 50 mg/ml).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or water may be stored at -20°C for up to 3 months.Shipping Code:RT -
AG-490 | JAK2 inhibitor
From $50.00CAS:133550-30-8Catalog Number:10-1091Activity:JAK2 inhibitorChemical Name:(E)-2-Cyano-3-(3,4-dihydrophenyl)-N-(phenylmethyl)-2-propenamideMolecular Weight:294.31Molecular Formula:C17H14N2O3Solubility:Soluble in DMSO (up to 25 mg/ml), in DMF (up to 40 mg/ml), or in Ethanol (up to 10 mg/ml).Physical Properties:Tan solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO, DMF, or ethanol may be stored at -20°C for up to 1 month.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21
Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21
Website Created by Advanta Advertising LLC.