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JAK-STAT

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of AG-490 | JAK-2 inhibitor | CAS 133550-30-8
    $50.00
    AG-490 (133550-30-8) is a potent inhibitor of the JAK-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells, which abundantly express JAK-2, AG-490 dose-dependently blocked cell growth, induced apoptosis and...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure Lestaurtinib | FLT3/TrkA inhibitor | CAS 111358-88-4
    $60.00
    Lestaurtinib (111358-88-4) is a potent and selective FLT3 inhibitor (IC50= 2 nM).1,2 Inhibits RET and RET phosphorylation in medullary thyroid carcinoma cells.3 Suppresses JAK2/STAT5 signaling and the proliferation of...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure Niclosamide | STAT3 signaling inhibitor | CAS 50-65-7
    $28.00
    Niclosamide (50-65-7) reversibly inhibits mTORC1 signaling and stimulates autophagy1. Inhibits activation and nuclear translocation of STAT3 selectively over STAT1 and STAT5. Niclosamide inhibits transcription of STAT3...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Stattic | STAT3 inhibitor | CAS 19983-44-9
    $45.00
    Stattic (19983-44-9) is a STAT3 inhibitor that inhibits binding of tyrosine-phosphorylated peptides to STAT3 SH2 domain and inhibiting STAT3 activation, dimerization and nuclear translocation1. Displays selectivity over...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Tofacitinib | JAK inhibitor | CAS 477600-75-2
    $60.00
    Tofacitinib (477600-75-2) is a potent pan-JAK inhibitor, IC50s=1, 20 and 112 nM for JAK3, JAK2 and JAK1 respectively.1 Displays potent antiinflammatory2 and immunosuppressant3 activity. Promotes a white-to-brown metabolic...

  • WP1066 | JAK2/STAT3 inhibitor
    $79.00
    WP1066 (857064-38-1) is an inhibitor of the JAK2/STAT3 pathway as well as STAT5 and AKT.1,2,3 It downregulated Bcl-XL, Mcl-1, and c-myc while activating Bax and inducing apoptosis.1 Active against human malignant glioma...

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