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MAPK

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  • Binimetinib | MEK1/2 inhibitor
    $39.00
    Binimetinib (606143-89-9) is a potent (IC50 = 12 nM) and selective allosteric inhibitor of MEK1/2.1,2 Recently approved by the FDA for treatment of melanoma in combination with Encorafenib. Binimetinib has had limited...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of GW-5074 | c-Raf1 inhibitor | CAS 220904-83-6
    $50.00
    GW-5074 (220904-83-6) is a potent inhibitor of cRAF1 kinase (IC50 = 9 nM). Displays 100-fold selectivity for cRAF1 over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm. GW-5074 displays neuroprotective effects In...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Hypothemycin | MEK inhibitor | CAS 76958-67-3
    $200.00
    Hypothemycin (76958-67-3) is a potent and selective inhibitor of MEK.1-3 Acts via covalent binding to Cys residue.2 In cells, hypothemycin inhibits the MEK-ERK axis with sufficient selectivity to normalize transformed...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of PD-98059 | MEK inhibitor | CAS 167869-21-8
    $45.00
    PD-98059 (167869-21-8) is an inhibitor of mitogen-activated protein kinase kinase (MKK / MEK). Acts via binding to the inactivated form of MEK, preventing its phosphorylation by cRAF or MEK kinase (IC50=2-7μM).1,2...

  • Focus Biomolecules supplier, chemical structure of Sorafenib | Inhibitor of Raf-1 and other kinases | CAS 475207-59-1
    $40.00
    Sorafenib (475207-59-1; base) was initially developed as a Raf kinase inhibitor, IC50 = 6 nM, but has been shown to inhibit many receptor tyrosine kinases including BRAF (IC50 = 22 nM); VEGFR-2 (IC50 = 90 nM); VEGFR-3 (IC50...

  • Focus Biomolecules supplier, chemical structure of U0126 | Selective MEK1 and MEK2 inhibitor | CAS 109511-58-2
    $90.00
    U0126 (109511-58-2) is a highly selective inhibitor of MEK1 and MEK2 in vitro and in vivo. Unlike PD98059 (Cat.# 10-2159), which only inhibits the activation of MEK1 and MEK2, U0126 inhibits both the active and inactive...

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