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  • Focus Biomolecules supplier, chemical structure of Cytochalasin D | Disrupts actin filaments | CAS 22144-77-0
    Cytochalasin D (22144-77-0) is a potent inhibitor of actin polymerization which also causes the disruption of actin filaments. More potent that cytochalasin B (10-fold) and does not inhibit monosaccharide transport across...

  • Focus Biomolecules supplier, chemical structure of Importazole | Blocks importin-β-mediated nuclear import | CAS 662163-81-7
    Importazole (662163-81-7) specifically inhibits importin-β-mediated nuclear import without disrupting transportin-mediated nuclear import or CRM1-mediated nuclear export.1 When added to cells during mitosis,...

  • Focus Biomolecules cell signaling reagent supplier, structure of Mirin | Mre11-Rad50-Nbs1 inhibitor | CAS 299953-00-7
    Mirin (299953-00-7) is an inhibitor of the Mre11-Rad50-Nbs1(MRN) complex (IC50 = 12 μM for inhibition of ATM activity), part of the MRN-ATM(ataxia-telangiectasia mutated) pathway, an essential pathway for sensing and...

  • Salirasib | 162520-00-5 | Structure | Supplier
    Salirasib (162520-00-5) is a synthetic farnesylcysteine mimetic that inhibits ras proteins1,2 via disruption of interactions between the S-Prenyl moiety of Ras and the membrane anchorage domains3.  It has been...

  • SU-5402 | FGFR Phosphorylation inhibitor
    SU-5402 (215543-92-3) inhibits FGFR phosphorylation in vitro, in cell culture1, and in mouse tumor cell models2. SU-5402 can suppress ECP induced cardiomyocyte differentiation of P19CL6 embryonic carcinoma cells via an FGFR3...

  • Focus Biomolecules supplier, chemical structure of WEB-2086 | PAF receptor antagonist | CAS 105219-56-5
    WEB-2086 (105219-56-5) is a potent and selective antagonist of the platelet activating factor (PAF) receptor (Ki = 16.3 nM).1 Displays an activity profile which includes antiinflammatory, antiangiogenesis and anticancer...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of YM-155 | Survivin inhibitor | CAS 781661-94-7
    YM-155 (781661-94-7) is a novel small molecule survivin suppressant. YM-155 suppresses expression of survivin (a member of the IAP family) and induced apoptosis in human tumor cell lines at 10 nmol/L with little effect on...

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