Veratramine | Cyclopamine analog

CAS:
60-70-8
Catalog Number:
10-1147
Activity:
Cyclopamine analog
Chemical Name:
(3β, 23β)-14,15,16,17-Tetrahydroveratraman-3,23-diol
Alternate Names:
NSC 17821; NSC 23880
Molecular Weight:
409.60
Molecular Formula:
C27H39NO2
Solubility:
Soluble in DMSO (up to 12 mg/ml) or in Ethanol (up to 10 mg/ml)
Physical Properties:
Tan solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Available Options

Size :PriceQuantity 
5 mg$50.00
25 mg$200.00

Veratramine (60-70-8) is a teratogenic steroidal alkaloid found in the corn lily (Veratrum sp.).1,2 It is an analog of cyclopamine which can inhibit the hedgehog signaling pathway-dependent proliferation in NIH/3T3 cells at 8 μM.1  Cell permeable.

SPECIAL HANDLING PRECAUTIONS: This product is teratogenic. Women who are, or may be pregnant should not handle veratramine

References/Citations:

1) Tang et al. (2010), Antitumor and antiplatelet activity of alkaloids from veratrum dahuricum;  Phytother. Res., 24 821
2) Mahindroo et al. (2009), Hedgehog-Gli signaling pathway inhibitors as anticancer agents;  J. Med. Chem., 52 3829

CAS:
60-70-8
Catalog Number:
10-1147
Activity:
Cyclopamine analog
Chemical Name:
(3β, 23β)-14,15,16,17-Tetrahydroveratraman-3,23-diol
Alternate Names:
NSC 17821; NSC 23880
Molecular Weight:
409.60
Molecular Formula:
C27H39NO2
Solubility:
Soluble in DMSO (up to 12 mg/ml) or in Ethanol (up to 10 mg/ml)
Physical Properties:
Tan solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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