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Wnt/b-Catenin

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  • Focus Biomolecules reagent supplier, chemical structure of Destruxin B | Apoptosis inducer; anticancer agent | CAS 2503-26-6
    $125.00
    Destruxin B (2503-26-6) is a cyclic depsipeptide produced by various species of fungi.1 Induces apoptosis in human nonsmall cell lung cancer cells.2 Displays selective cytotoxic effects on human oral cancer cell lines.3...

  • Focus Biomolecules cell signaling reagent supplier, structure of FH-535 | Wnt/beta-cantenin inhibitor | CAS 108409-83-2
    $50.00
    FH-535 (108409-83-2) suppresses Wnt/β-catenin signaling. It antagonizes PPARγ and PPARδ ligand-dependent activation which is mediated by inhibition of recruitment of the coactivators β-catenin and GRIP1...

  • Focus Biomolecules cell signaling supplier, chemical structure of ICG-001 | Wnt beta-catenin inhibitor | CAS 847591-62-2
    $65.00
    ICG-001 (847591-62-2) inhibits TCF/β-catenin mediated transcription by specifically blocking β-catenin/CBP interaction References/Citations 1) Emami et al. (2004), A small molecule inhibitor of...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of iCRT5 | Beta-catenin inhibitor | CAS 18623-44-4
    $57.00
    iCRT5 (18623-44-4) is a selective CRT (β-catenin-responsive transcription) inhibitor.1  IC50=18 nM for Wnt responsive STF16 luciferase. Acts via interfering with the β-catenin, TCF4 interaction.1 Displays poor...

  • Focus Biomolecules supplier, structure of IWP-2 | PORCN inhibitor, Wnt/Beta-catenin pathway inhibitor | CAS 686770-61-1
    $75.00
    IWP-2 (686770-61-6) is an inhibitor of Wnt secretion and processing. It blocks Wnt-dependent signaling (IC50= 27 nM) by inhibition of the O-acyltransferase Porcn1. Induces cardiomyocyte differentiation from human pluripotent...

  • Focus Biomolecules supplier, chemical structure of KY-02111 | Wnt pathway inhibitor | CAS 1118807-13-8
    $55.00
    KY-02111 (1118807-13-8) promotes cardiac differentiation of human pluripotent stem cells. Inhibits Wnt signaling in a manner that appears to be distinct from previously described Wnt inhibitors.1 Cell permeable and active in...

  • Focus Biomolecules reagent supplier, chemical structure of Nitazoxanide | Antiviral and antiparasitic agent | CAS 55981-09-4
    $40.00
    Nitazoxanide (55981-09-4) is a clinically relevant antiparasitic agent.1It has since been repurposed as a broad-spectrum antiviral agent that is active against many RNA and DNA viruses including influenza, Hepatitis B and C,...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of PNU 74654 | Wnt pathway blocker | CAS 113906-27-7
    $60.00
    PNU-75654 (113906-27-7) disrupts the Wnt signaling pathway via inhibition of the interaction (KD50 = 450 nM) between β-catenin and T cell factor 4 (Tcf4). References/Citations1) Trosset et al. (2006) Inhibition of...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Wnt-C59 | Porcupine Inhibitor | CAS 1243243-89-1
    $65.00
    Wnt-C59 (1243243-89-1) is a potent (IC50 = 74 pmol/L) inhibitor of Porcupine (PORCN), a Wnt-acyltransferase.1 Blockage of Wnt-acyltransferase prevents secretion of all Wnt isoforms.  It was able to block progression of...

  • Focus Biomolecules supplier, chemical structure of XAV-939 | Tankyrase inhibitor, Cardiomyogenesis inducer | CAS 284028-89-3
    $45.00
    XAV-939 (284028-89-3) is a tankyrase inhibitor (IC50=11 and 4 nM for TNKS1 and 2 respectively).  Antagonizes wnt signaling via stimulation of β-catenin degradation and stabilization of actin.1  XAV-939...

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