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Small G-Proteins

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of MLS-532223 | GTPase inhibitor | CAS 16616-39-0
    $62.00
    MLS-532223 is a high-affinity selective inhibitor of Rho family GTPases (EC50=10 μM). It inhibits EGF-stimulated Rac1 activation (3-10 μM). Cell permeable. References/Citations1) Surviladze et al. (2010),...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of MLS-573151 | Cdc42 inhibitor | CAS 10179-57-4
    $65.00
    MLS-573151 (10179-57-4) is a potent and specific inhibitor of Cdc42 a small GTPase of the Rho-subfamily (IC50=2 μM).1 A useful agent fpr probing the involvement of Cdc42 in cellular signaling and physiology.2...

  • Focus Biomolecules cell signaling supplier, chemical structure of NSC-23766 | Rac1 GTPase inhibitor | CAS 733767-34-5
    $67.00
    NSC-23766 (733767-34-5) is a selective inhibitor of Rac1-GEF interaction. Prevents Rac1 activation by Rac-specific guanine nucleotide exchange factors (GEFs) Trio and Tiam1 (IC50 ca. 50 μM) with no effect on the closely...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Salirasib | Ras inhibitor | CAS 162520-00-5
    $30.00
    Salirasib (162520-00-5) is a synthetic farnesylcysteine mimetic that inhibits ras proteins1,2 via disruption of interactions between the S-Prenyl moiety of Ras and the membrane anchorage domains3.  It has been...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Sulindac Sulfide | NFkB inhibitor | CAS 32004-67-4
    $50.00
    Sulindac sulfide (32004-67-4) is the active metabolite of cyclooxygenase inhibitor sulindac.1 Strongly inhibits Ras induced malignant transformation and Ras/Raf dependent transactivation.2 Sulindac sulfide induces apoptosis...

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