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Stem Cells

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  • (±) Tranylcypromine hemisulfate | Demethylase inhibitor
    $40.00
    Tranylcypromine (13492-01-8) is an irreversible and non-selective monoamine oxidase inhibitor.1,2 It has been shown to inhibit the histone demethylase BHC110/LSD1.3,4 References/Citations1) Knoll et al. (1980), Monoamine...

  • 1-EBIO | K+ channel activator; Promotes cardiomyocyte differentiation
    $40.00
    1-EBIO (10045-45-1) is a direct activator of small-conductance Ca2+-activated K+ channels (SK) which dose-dependently relaxes rat mesenteric vessels.1  Reverses ischemia-induced cognitive impairment2 and displays...

  • 20(S)-Hydroxycholesterol | Smoothened activator
    $45.00
    20-(S)-Hydroxycholesterol (516-72-3) is an endogenous ligand for the LXR receptor.1 It has anti-adipogenic and pro-osteogenic effects in mesenchymal stem cells mediated via a non-LXR dependent pathway.2 The osteogenic...

  • Focus Biomolecules cell signaling reagent supplier, structure of 24(S),25-Epoxycholesterol | LXR agonist | CAS 77058-74-3
    $150.00
    24(S),25-Epoxycholesterol (77058-74-3) is a cholesterol metabolite that acts as an endogenous agonist for nuclear receptor LXR.1 Controls cellular cholesterol homeostasis.2 24(S),25-Epoxycholesterol promotes neural...

  • Focus Biomolecules cell signaling reagent supplier, structure of 5-Azacytidine | DNA hypomethylation agent | CAS 320-67-2
    $20.00
    5-Azacytidine (320-67-2) is specific inhibitor of DNA methyltransferase1. Incorporates into DNA and covalently reacts with and inhibits DNA methyltransferases. Induces demethylation and reactivation of silenced genes2...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of 6BIO | GSK-3 inhibitor | CAS 667463-62-9
    $65.00
    6BIO (667463-62-9) is a potent and selective inhibitor of glycogen synthase kinase-3 (GSK-3) IC50=5 nM.1 The first pharmacological agent shown to maintain self-renewal in human and mouse embryonic stem cells...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of A83-01 | ALK inhibitor | CAS 909910-43-6
    $78.00
    A83-01 (909910-43-6) is a potent and selective ALK4, 5 and 7 inhibitor.1,2 IC50 = 45, 12 and 7.5 nM respectively. Prevents phosphorylation of Smad2/3 and growth inhibition induced by TGFβ.2 Inhibits...

  • AS-8351 | 796-42-9 | Structure | Supplier
    $50.00
    AS-8351 (796-42-9) has been used in a cocktail of nine small molecules used to efficiently induce cardiac reprogramming of human fibroblasts.1 It is believed that AS-8351 exerts its effects by modulating the activity of the...

  • BAY K8644 | L-type calcium channel activator
    $75.00
    BAY K8644 (71145-03-4) is an L-type Ca2+-channel activator with positive inotropic and vasoconstrictive effects.1-4 References/Citations1) Schramm et al. (1983) Novel Dihydropyridines with positive inotropic action through...

  • Focus Biomolecules supplier, chemical structure of B!X-01294 | Histone Methyltransferase inhibitor | CAS 935693-62-2
    $60.00
    BIX-01294 (935693-62-2) is a selective inhibitor of G9a histone methyltransferase (G9aHMTase; IC50 = 1.7 μM) as well as GLP HMTase (IC50 = 38 μM) leading to a decrease in H3K9me2(histone H3 lysine 9 methylation) in...

  • BRD 7116 | 329059-55-4 | Structure
    $50.00
    BRD 7116 (329059-55-4) inhibits leukemia stem cell (LSC) activity (EC50 = 200 nM). Displays a >100-fold selectivity for LSCs over normal hematopoietic stem cells.1 References/Citations 1) Hartwell et al. (2013),...

  • Focus Biomolecules cell signaling reagent supplier, structure of CHIR-99021 | GSK3 beta inhibitor | CAS 252917-06-9
    $70.00
    CHIR-99021 (252917-06-9) is a potent and selective inhibitor of glycogen synthase kinase-3β (GSK3β, IC50 = 5 nM) and GSK3α (IC50 = 10 nM)1. Induces osteoblastogenesis, increases mineralization and inhibits...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Ciglitazone | PPARŒ≥ agonist | CAS 74772-77-3
    $80.00
    Ciglitazone (74772-77-3) is a PPARγ agonist (EC50=3 μM). Stimulates adipogenesis in human mesenchymal stem cells. Ciglitazone inhibits HUVEC differentiation and angiogenesis. Cell permeable. References/Citations1)...

  • Focus Biomolecules cell signaling reagent supplier, structure Cyclopamine | Inhibits hedgehog signaling | CAS 4449-51-8
    $45.00
    Cyclopamine (4449-51-8) is a naturally occurring steroidal alkaloid with teratogenic activity. Blocks sonic hedgehog signaling by binding to smoothened. Antitumor activity. Cell Permeable. References/Citations1) Watkins et...

  • DAPT | gamma-secretase inhibitor
    $60.00
    DAPT (208255-80-5)is an inhibitor of γ-secretase (IC50 in human primary neurons = 115 nM for total Aβ or 200 nM for Aβ42 specifically)1. Oral administration of DAPT has been shown to reduce levels of Aβ...

  • Decitabine | DNA hypomethylation agent
    $60.00
    Decitabine (2353-33-5) inhibits DNA methyltransferase. Induces demethylation and reactivation of silenced genes. Increases stem cell reprogramming efficiency. Decitabine stimulates osteogenic differentiation of human bone...

  • Focus Biomolecules cell signaling tech supplier, structure Dexamethasone | Apoptosis inducing glucocorticoid | CAS 50-02-2
    $55.00
    Dexamethasone (50-02-2) is a synthetic glucocorticoid used clinically in the treatment of a variety of inflammatory and autoimmune conditions. References/Citations1) Merck Index 14...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure Dorsomorphin | AMPK inhibitor | CAS 866405-64-3
    $60.00
    Dorsomorphin (866405-64-3) is a potent, selective and ATP-competitive inhibitor of AMP-activated protein kinase (AMPK) (Ki = 109 nM).1 It displays no significant inhibition of ZAPK, SYK, PKCT, PKA and JAK3. It inhibits bone...

  • DZNep | 102052-95-9 | Structure | Supplier
    $142.00
    DZNep (102052-95-9) is a potent histone methyltransferase inhibitor which decreases global histone methylation.1 Inhibits trimethylation of H3K27 and H4K20 in vitro.1 Selectively induces apoptosis in multiple cancer cell...

  • Focus Biomolecules supplier, chemical structure of Ethopropazine HCl | Promotes stem cell self renewal | CAS 1094-08-2
    $90.00
    Ethopropazine HCl (1094-08-2) is a butyrylcholinesterase inhibitor.1 Reduces drug-induced extrapyramidal motor syndrome. Parkinson's disease therapeutic.2 Alleviates thermal hyperalgesia in neuropathic rats...

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