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  • (±) Tranylcypromine hemisulfate | Demethylase inhibitor
    Tranylcypromine (13492-01-8) is an irreversible and non-selective monoamine oxidase inhibitor.1,2 It has been shown to inhibit the histone demethylase BHC110/LSD1.3,4 References/Citations1) Knoll et al. (1980), Monoamine...

  • Purmorphamine | Smoothened activator
    Purmorphamine induces osteogenesis in multipotent mesenchymal progenitor cells via activation of hedgehog signaling.1,2 Activation of hedgehog is achieved via direct targeting of Smoothened.3 Purmorphamine has also been used...

  • RepSox | TGFbetaR-1 / ALK5 inhibitor
    RepSox (446859-33-2) is a potent (IC50 ALK5 auto-P= 4 nM; IC50 TGF-β cellular assay = 23 nM) inhibitor of the TGF-β type I receptor (ALK5).1 RepSox can replace Sox2 in reprogramming adult cells into pluripotent...

  • Focus Biomolecules supplier, Reversine | Reverses differentiated cells to multipotent stem cells | CAS 656820-32-5
    Reversine (656820-32-5) induces differentiated myogenic-lineage-committed cells to become multipotent mesenchymal progenitor cells.1-2 Acts as a selective human A3 adenosine receptor antagonist (Ki = 0.66 μM).3 Cell...

  • RG-108 | DNA Methyltransferase inhibitor
    RG-108 (48208-26-0) is a non-nucleoside DNA methyltransferase inhibitor. IC50=115 nM1 Inhibits DNA methylation in human tumor cell lines without toxicity2. RG-108 enhances the reversion of neural progenitor cells to the...

  • SMER-28 | Structure | Supplier
    Induces autophagy via an mTOR-independent pathway. Enhances clearance of b-amyloid protein in cell lines and primary neuronal culture models.1-3  May be a useful lead compound for the development of new therapeutics for...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Trichostatin A | HDAC inhibitor | CAS 58880-19-6
    Trichostatin A (58880-19-6) is a potent and selective histone deacetylase (HDAC) inhibitor (Ki = 3.4 nM). Induces reversion of ras transformed cells to normal morphology. Trichostatin A induces dedifferentiation of...

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