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  • 1-EBIO | K+ channel activator; Promotes cardiomyocyte differentiation
    1-EBIO (10045-45-1) is a direct activator of small-conductance Ca2+-activated K+ channels (SK) which dose-dependently relaxes rat mesenteric vessels.1  Reverses ischemia-induced cognitive impairment2 and displays...

  • 20(S)-Hydroxycholesterol | Smoothened activator
    20-(S)-Hydroxycholesterol (516-72-3) is an endogenous ligand for the LXR receptor.1 It has anti-adipogenic and pro-osteogenic effects in mesenchymal stem cells mediated via a non-LXR dependent pathway.2 The osteogenic...

  • Focus Biomolecules cell signaling reagent supplier, structure of 24(S),25-Epoxycholesterol | LXR agonist | CAS 77058-74-3
    24(S),25-Epoxycholesterol (77058-74-3) is a cholesterol metabolite that acts as an endogenous agonist for nuclear receptor LXR.1 Controls cellular cholesterol homeostasis.2 24(S),25-Epoxycholesterol promotes neural...

  • Focus Biomolecules cell signaling reagent supplier, structure of 5-Azacytidine | DNA hypomethylation agent | CAS 320-67-2
    5-Azacytidine (320-67-2) is specific inhibitor of DNA methyltransferase1. Incorporates into DNA and covalently reacts with and inhibits DNA methyltransferases. Induces demethylation and reactivation of silenced genes2...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of A83-01 | ALK inhibitor | CAS 909910-43-6
    A83-01 (909910-43-6) is a potent and selective ALK4, 5 and 7 inhibitor.1,2 IC50 = 45, 12 and 7.5 nM respectively. Prevents phosphorylation of Smad2/3 and growth inhibition induced by TGFβ.2 Inhibits...

  • AS-8351 | 796-42-9 | Structure | Supplier
    AS-8351 (796-42-9) has been used in a cocktail of nine small molecules used to efficiently induce cardiac reprogramming of human fibroblasts.1 It is believed that AS-8351 exerts its effects by modulating the activity of the...

  • Focus Biomolecules cell signaling reagent supplier, structure of CHIR-99021 | GSK3 beta inhibitor | CAS 252917-06-9
    CHIR-99021 (252917-06-9) is a potent and selective inhibitor of glycogen synthase kinase-3β (GSK3β, IC50 = 5 nM) and GSK3α (IC50 = 10 nM)1. Induces osteoblastogenesis, increases mineralization and inhibits...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Ciglitazone | PPARŒ≥ agonist | CAS 74772-77-3
    Ciglitazone (74772-77-3) is a PPARγ agonist (EC50=3 μM). Stimulates adipogenesis in human mesenchymal stem cells. Ciglitazone inhibits HUVEC differentiation and angiogenesis. Cell permeable. References/Citations1)...

  • Focus Biomolecules cell signaling reagent supplier, structure Cyclopamine | Inhibits hedgehog signaling | CAS 4449-51-8
    Cyclopamine (4449-51-8) is a naturally occurring steroidal alkaloid with teratogenic activity. Blocks sonic hedgehog signaling by binding to smoothened. Antitumor activity. Cell Permeable. References/Citations1) Watkins et...

  • DAPT | gamma-secretase inhibitor
    DAPT (208255-80-5)is an inhibitor of γ-secretase (IC50 in human primary neurons = 115 nM for total Aβ or 200 nM for Aβ42 specifically)1. Oral administration of DAPT has been shown to reduce levels of Aβ...

  • Decitabine | DNA hypomethylation agent
    Decitabine (2353-33-5) inhibits DNA methyltransferase. Induces demethylation and reactivation of silenced genes. Increases stem cell reprogramming efficiency. Decitabine stimulates osteogenic differentiation of human bone...

  • Focus Biomolecules cell signaling tech supplier, structure Dexamethasone | Apoptosis inducing glucocorticoid | CAS 50-02-2
    Dexamethasone (50-02-2) is a synthetic glucocorticoid used clinically in the treatment of a variety of inflammatory and autoimmune conditions. References/Citations1) Merck Index 14...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure Dorsomorphin | AMPK inhibitor | CAS 866405-64-3
    Dorsomorphin (866405-64-3) is a potent, selective and ATP-competitive inhibitor of AMP-activated protein kinase (AMPK) (Ki = 109 nM).1 It displays no significant inhibition of ZAPK, SYK, PKCT, PKA and JAK3. It inhibits bone...

  • FH-1 | Induces hepatocyte differentiation
    FH-1 (2719-05-3) enhances differentiation of induced pluripotent stem cells (iPSC) to hepatocytes. Promotes the maturation of iPSC-derived hepatocytes.1 References/Citations 1) Shan et al. (2013), Identification of small...

  • Harmine | MAO-A and DYRK inhibitor
    Harmine (343-27-1) is a selective competitive and reversible inhibitor of MAO-A (IC50 = 8 μM).1 Harmine is a potent and specific inhibitor of both the kinase activity and autophosphorylation of tyrosine during translation...

  • Indolactam V | PKC activator; Stem cell inducer
    Indolactam V (-) (90365-57-4) is a PKC activator acting at the phorbol ester binding site.1,2 Directs differentiation of human and mouse ESCs to pancreatic cells.3   May be used, along with other agents, to...

  • Focus Biomolecules supplier, chemical structure of ISX9 | Neurogenic differentiation inducer | CAS 832115-62-5
    ISX9 (832115-62-5) promotes neurogenesis in vivo enhancing the proliferation and differentiation of hippocampal subgranular zone neuroblasts and enhances memory.1 Induces robust neuronal differentiation in adult neural...

  • Focus Biomolecules supplier, structure of IWP-2 | PORCN inhibitor, Wnt/Beta-catenin pathway inhibitor | CAS 686770-61-1
    IWP-2 (686770-61-6) is an inhibitor of Wnt secretion and processing. It blocks Wnt-dependent signaling (IC50= 27 nM) by inhibition of the O-acyltransferase Porcn1. Induces cardiomyocyte differentiation from human pluripotent...

  • Focus Biomolecules supplier, chemical structure of Kartogenin | Induces chrondrocyte differentiation | CAS 4727-31-5
    Kartogenin (4727-31-5) promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes (EC50 = 100 nM). Kartogenin displays chrondroprotective effects in vitro and is efficacious in two animal...

  • Focus Biomolecules supplier, chemical structure of KY-02111 | Wnt pathway inhibitor | CAS 1118807-13-8
    KY-02111 (1118807-13-8) promotes cardiac differentiation of human pluripotent stem cells. Inhibits Wnt signaling in a manner that appears to be distinct from previously described Wnt inhibitors.1 Cell permeable and active in...

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