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  • Focus Biomolecules reagent supplier, chemical structure of BAY K8644 | L-type calcium channel activator | CAS 71145-03-4
    $75.00
    BAY K8644 (71145-03-4) is an L-type Ca2+-channel activator with positive inotropic and vasoconstrictive effects.1-4 References/Citations1) Schramm et al. (1983) Novel Dihydropyridines with positive inotropic action through...

  • Focus Biomolecules supplier, chemical structure of B!X-01294 | Histone Methyltransferase inhibitor | CAS 935693-62-2
    $60.00
    BIX-01294 (935693-62-2) is a selective inhibitor of G9a histone methyltransferase (G9aHMTase; IC50 = 1.7 μM) as well as GLP HMTase (IC50 = 38 μM) leading to a decrease in H3K9me2(histone H3 lysine 9 methylation) in...

  • Focus Biomolecules cell signaling reagent supplier, structure of CHIR-99021 | GSK3 beta inhibitor | CAS 252917-06-9
    $70.00
    CHIR-99021 (252917-06-9) is a potent and selective inhibitor of glycogen synthase kinase-3β (GSK3β, IC50 = 5 nM) and GSK3α (IC50 = 10 nM)1. Induces osteoblastogenesis, increases mineralization and inhibits...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Ciglitazone | PPARŒ≥ agonist | CAS 74772-77-3
    $80.00
    Ciglitazone (74772-77-3) is a PPARγ agonist (EC50=3 μM). Stimulates adipogenesis in human mesenchymal stem cells. Ciglitazone inhibits HUVEC differentiation and angiogenesis. Cell permeable. References/Citations1)...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure DZNep | Methyltransferase inhibitor | CAS 102052-95-9
    $142.00
    DZNep (102052-95-9) is a potent histone methyltransferase inhibitor which decreases global histone methylation.1 Inhibits trimethylation of H3K27 and H4K20 in vitro.1 Selectively induces apoptosis in multiple cancer cell...

  • Focus Biomolecules supplier, chemical structure of Forskolin | Adenylate cyclase activator | CAS 66575-29-9
    $60.00
    Forskolin (66575-29-9) is a widely used adenylate cyclase activator.1 Forskolin also is a positive inotropic agent, vasodilator and induces platelet activation among other activities.2-5 References/Citations1) Awad et al...

  • Focus Biomolecules supplier, chemical structure of LM11A-31 | p75NTR ligand | Promotes neurogenesis | CAS 1243259-19-9
    $48.00
    LM11A-31 (CAS 1243259-19-9) is a nonpeptide neurotrophic factor receptor p75 (p75NTR) agonist which promotes survival signaling in neurotrophin-responsive cells.1 Promotes functional recovery in a mouse model of spinal...

  • Focus Biomolecules supplier, chemical structure Neurodazine | Induces stem cell neuronal differentiation | CAS 937807-66-4
    $70.00
    Neurodazine (937807-66-4) was able to induce neurogenesis of non-pluripotent myoblasts and cells derived from mature, human skeletal muscle (using 2 μM neurodazine). It was able to upregulate genes involved in...

  • Focus Biomolecules supplier, chemical structure of PluriSln#1 | Stearoyl CoA desaturase inhibitor | CAS 91396-88-2
    $50.00
    PluriSln#1 (91396-88-2) is an inhibitor of stearoyl-coA desaturase (SCD1). PluriSln#1 was able to selectively eliminate human pluripotent stem cells (hPSCs) while not affecting a large array of progenitor and differentiated...

  • Focus Biomolecules cell signaling supplier, chemical structure of Purmorphamine | Smoothened activator | CAS 483367-10-8
    $75.00
    Purmorphamine (CAS  483367-10-8) induces osteogenesis in multipotent mesenchymal progenitor cells via activation of hedgehog signaling.1,2 Activation of hedgehog is achieved via direct targeting of Smoothened.3...

  • Focus Biomolecules cell signaling supplier, chemical structure of RepSox | TGFbetaR-1 | ALK5 inhibitor | CAS 446859-33-2
    $65.00
    RepSox (446859-33-2) is a potent (IC50 ALK5 auto-P= 4 nM; IC50 TGF-β cellular assay = 23 nM) inhibitor of the TGF-β type I receptor (ALK5).1 RepSox can replace Sox2 in reprogramming adult cells into pluripotent...

  • Focus Biomolecules cell signaling tech supplier, structure of Thiazovivin | Induces stem cell generation | CAS 1226056-71-8
    $75.00
    Thiazovivin (1226056-71-8) dramatically improves (200-fold) the efficiency of induced pluripotent stem cell generation from human fibroblasts1. Induces direct conversion of porcine embryonic fibroblasts into adipocytes2...

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