Verteporfen | YAP Inhibitor
(4R,4aS)-18-Ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-24H,26H-benzo[b]porphine-9,13-dipropanoic acid monomethyl ester
NMR (Conforms)
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(4R,4aS)-18-Ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-24H,26H-benzo[b]porphine-9,13-dipropanoic acid monomethyl ester
IDE2 (1136466-93-7) induces robust differentiation of embryonic stem cells into endoderm (EC50 = 223 nM) in both mouse and human cells via activation of the TGFß signaling pathway.1 It was
IDE1 (1160927-48-9) induces robust differentiation of embryonic stem cells into endoderm (EC50 = 125 nM) in both mouse and human cells via activation of the TGFß signaling pathway.1,2 It has
WS6 (1421227-53-3) stimulates human β-cell proliferation both in a dispersed islet proliferation assay and in intact human cultures.1 It has been shown to induce both α-
PY-60 (2765218-56-0) activates YAP transcriptional activity (EC50 = 1.6 µM) via delocalization of annexin A2 (ANXA2) from cell membranes leading to Hippo inactivation, a key controller of YAP.1 It was
(4R,4aS)-18-Ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-24H,26H-benzo[b]porphine-9,13-dipropanoic acid monomethyl ester
CPI203 (1446144-04-2), a JQ1 analog, is a potent and selective inhibitor of the BET bromodomain BRD4 (IC50 = 26 nM).1 It helps promote the maintenance of hematopoietic stem
UNC0224 (1197196-48-7) is a potent inhibitor of histone methyltransferases G9a / EHMT2 (IC50 = 15 nM) and GLP / EHMT1 (IC50 ~ 39 nM) but not
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