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PhysioProcesses

Stem cells

Stem cells are unspecialized cells that can renew themselves via cell division and can differentiate to become tissue- or organ-specific cells. Embryonic stem cells are pluripotent – able to develop into any cell type in the human body. Adult or somatic stem cells are typically multipotent cells that are only able to differentiate into cells related to their tissue of origin. Induced pluripotent stem cells are adult stem cells that have been reprogrammed with various transcription factors to enable them to have embryonic stem cell-like properties. Many types of diseases and conditions that would benefit from the generation/regeneration of tissue are being investigated using stem cell-based therapies.

Dedifferentiation

Verteporfen | YAP Inhibitor

CAS:
129497-78-5
Catalog Number:
10-3487
Activity:
YAP inhibitor
Chemical Name:

(4R,4aS)-18-Ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-24H,26H-benzo[b]porphine-9,13-dipropanoic acid monomethyl ester

Alternate Names:
CL 318952; BPD-MA
Molecular Weight:
718.79
Molecular Formula:
C41H42N4O8
Solubility:
Soluble in DMSO (up to 14 mg/ml)
Physical Properties:
Black solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchsae as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Purmorphamine | Smoothened activator

CAS:
483367-10-8
Catalog Number:
10-4622
Activity:
Smoothened activator
Chemical Name:
1-(1-Naphthoxy)-6-(4-morpholinoanilino)-9-cyclohexylpurine
Molecular Weight:
520.62
Molecular Formula:
C31H32N6O2
Solubility:
Soluble in DMSO (up to 10 mg/ml)
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

RepSox | TGFß type I / ALK5 inhibitor

CAS:
446859-33-2
Catalog Number:
10-4546
Activity:
TGFß type I/ALK5 inhibitor
Chemical Names:
2-(3-(6-Methylpyridine-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine; E-616452; SNJ 2511
Molecular Weight:
287.32
Molecular Formula:
C17H13N5
Solubility:
Soluble in DMSO (>25 mg/ml); ethanol (10 mg/ml)
Physical Properties:
Pale yellow solid
Purity:
99% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Differentiation

IDE2 | Inducer of Definitive Endoderm

IDE2 (1136466-93-7) induces robust differentiation of embryonic stem cells into endoderm (EC50 = 223 nM) in both mouse and human cells via activation of the TGFß signaling pathway.1 It was

IDE1 | Inducer of Definitive Endoderm

IDE1 (1160927-48-9) induces robust differentiation of embryonic stem cells into endoderm (EC50 = 125 nM) in both mouse and human cells via activation of the TGFß signaling pathway.1,2 It has

TTNPB | Retinoid RAR agonist

CAS:
71441-28-6
Catalog Number:
10-2517
Activity:
Retinoid RAR agonist
Chemical Names:
4-[(E)-2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl]benzoic acid
Alternate Name:
Ro 13-7410; AGN-191183
Molecular Weight:
348.49
Molecular Formula:
C24H28O3
Solubility:
Soluble in DMSO (4 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Generation

GSK126 | EZH2 methyltransferase inhibitor

CAS:
1346574-57-9
Catalog Number:
10-3394
Activity:
EZH2 methyltransferase inhibitor
Chemical Names:
N-[(1,2-Dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-methyl-1-[(1S)-1-methylpropyl]-6-[6-(1-piperazinyl)-3-pyridinyl]-1H-indole-4-carboxamide
Molecular Weight:
526.69
Molecular Formula:
C31H38N6O2
Solubility:
Soluble in DMSO (16 mg/ml)
Physical Properties:
Cream solid
Purity:
>98% HPLC/TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Chroman 1 | ROCK II inhibitor / Stem cell cytoprotectant

CAS:
1273579-40-0
Catalog Number:
10-4912
Activity:
ROCK II inhibitor / Stem cell cytoprotectant
Chemical Names:
(3S)-N-[2,[2-(Dimethylamino)ethoxy)-4-(1H-pyrazol-4-yl)phenyl]-6-methoxy-3,4-dihydro-2H-chromen-3-carboxamide
Molecular Weight:
436.51
Molecular Formula:
C24H28N4O4
Solubility:
Soluble in DMSO (at least 50 mg/ml)
Physical Properties:
White solid
Purity:
99% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Proliferation

PY-60 | YAP Activator

PY-60 (2765218-56-0) activates YAP transcriptional activity (EC50 = 1.6 µM) via delocalization of annexin A2 (ANXA2) from cell membranes leading to Hippo inactivation, a key controller of YAP.1 It was

TPCA-1 | IkB kinase inhibitor

CAS:
507475-17-4
Catalog Number:
10-5571
Activity:
IkB kinase inhibitor
Chemical Names:
2-[(Aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide
Molecular Weight:
229.29
Molecular Formula:
C12H10FN3O4S
Solubility:
Soluble in DMSO (30 mg/ml)
Physical Properties:
Pale yellow solid
Purity:
>98% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Verteporfen | YAP Inhibitor

CAS:
129497-78-5
Catalog Number:
10-3487
Activity:
YAP inhibitor
Chemical Name:

(4R,4aS)-18-Ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-24H,26H-benzo[b]porphine-9,13-dipropanoic acid monomethyl ester

Alternate Names:
CL 318952; BPD-MA
Molecular Weight:
718.79
Molecular Formula:
C41H42N4O8
Solubility:
Soluble in DMSO (up to 14 mg/ml)
Physical Properties:
Black solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchsae as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Self renewal/maintenance

CPI203 | BET bromodomain inhibitor

CPI203 (1446144-04-2), a JQ1 analog, is a potent and selective inhibitor of the BET bromodomain BRD4 (IC50 = 26 nM).1 It helps promote the maintenance of hematopoietic stem

Chroman 1 | ROCK II inhibitor / Stem cell cytoprotectant

CAS:
1273579-40-0
Catalog Number:
10-4912
Activity:
ROCK II inhibitor / Stem cell cytoprotectant
Chemical Names:
(3S)-N-[2,[2-(Dimethylamino)ethoxy)-4-(1H-pyrazol-4-yl)phenyl]-6-methoxy-3,4-dihydro-2H-chromen-3-carboxamide
Molecular Weight:
436.51
Molecular Formula:
C24H28N4O4
Solubility:
Soluble in DMSO (at least 50 mg/ml)
Physical Properties:
White solid
Purity:
99% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Emricasan | pan-Caspase inhibitor

CAS:
254750-02-2
Catalog Number:
10-4280
Activity:
pan-Caspase inhibitor
Chemical Names:
(3S)-3-[[(2S)-2-[[2-(2-tert-butylanilino)-2-oxoacetyl]amino]propanoyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid
Alternate Name:
IDN-6556; PF-03491390
Molecular Weight:
569.51
Molecular Formula:
C26H27F4N3O7
Solubility:
Soluble in DMSO (20 mg/ml)
Physical Properties:
White solid
Purity:
98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Other Stem Cells

A939572 | SCD1 inhibitor

CAS:
1032229-33-6
Catalog Number:
10-4639
Activity:
Potent SCD1 inhibitor
Chemical Names:
4-(2-Chlorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide
Molecular Weight:
387.86
Molecular Formula:
C20H22ClN3O3
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
White solid
Purity:
98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

GW788388 | TGF-ß receptor kinase inhibitor

CAS:
452342-67-5
Catalog Number:
10-5521
Activity:
TGF-ß receptor kinase inhibitor
Chemical Names:
4-(4-(3-(Pyridin-2-yl)-1H-pyrazol-4-yl)pyridin-2-yl)-N-(tetrahydro-2H-pyran-4-yl)benzamide
Molecular Weight:
425.49
Molecular Formula:
C25H23N5O2
Solubility:
Soluble in DMSO (18 mg/ml with warming)
Physical Properties:
Off-white solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT