Self renewal/maintenance
Showing 1–12 of 25 results
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Dedifferentiation
(±) Tranylcypromine hemisulfate | Demethylase inhibitor
Tranylcypromine (13492-01-8) is an irreversible and non-selective monoamine oxidase inhibitor.1,2 It has been shown to inhibit the histone demethyl...$40.00 – $150.00 Select options -
Cardiovascular
6BIO | GSK-3 inhibitor
6BIO (667463-62-9) is a potent and selective inhibitor of glycogen synthase kinase-3 (GSK-3) IC50=5 nM.1 The first pharmacological agent shown to m...$65.00 – $260.00 Select options -
ALK
A 83-01 | ALK inhibitor
A 83-01 (909910-43-6) is a potent and selective ALK4, 5 and 7 inhibitor.1,2 IC50 = 45, 12 and 7.5 nM respectively. Prevents phosphorylation of Smad...$50.00 – $180.00 Select options -
Adipogenesis
CHIR-99021 | GSK3ß inhibitor
CHIR-99021 (252917-06-9) is a potent and selective inhibitor of glycogen synthase kinase-3β (GSK3β, IC50 = 5 nM) and GSK3α (IC50 = 10 nM).1 Induces...$60.00 – $170.00 Select options -
New Products
Chroman 1 | ROCK II inhibitor / Stem cell cytoprotectant
Chroman 1 (1273579-40-0) is an extremely potent inhibitor of Rho kinase II (ROCK-II)1,2 – it displayed greater selectivity and potency compared to ...$49.00 – $195.00 Select options -
AMPK
Cordycepin | AMPK activator
Cordycepin (73-03-0) is an adenosine analog lacking the hydroxyl at the 3’ position. Inhibits PARP1 and polyadenylation2. Displays anti-inflammator...$40.00 – $120.00 Select options -
New Products
CPI203 | BET bromodomain inhibitor
CPI203 (1446144-04-2), a JQ1 analog, is a potent and selective inhibitor of the BET bromodomain BRD4 (IC50 = 26 nM).1 It helps promote the maintena...$100.00 – $350.00 Select options -
New Products
EHNA HCl | PDE2 inhibitor
EHNA (51350-19-7) inhibits phosphodiesterase 2 (PDE2) (IC50 = 0.8 – 5.5 µM in a variety of tissues and species) over PDE1, PDE3, or PDE4 (IC50 valu...$60.00 – $240.00 Select options -
Bioinorganic chemistry
Eltrombopag | Small molecule thrombopoietin agonist
Eltrombopag (496775-61-2) is a novel, orally active, small molecule human thrombopoietin receptor (TPO-R) agonist, EC50=0.27 μM.1,2 Maintains human...$55.00 – $165.00 Select options -
New Products
Emricasan | pan-Caspase inhibitor
Emricasan (254750-02-2) is a liver-targeted antiapoptotic pan-caspase inhibitor.1,2 It has been investigated as a hepatoprotective agent in the tre...$80.00 – $310.00 Select options -
Cardiovascular
Go-6983 | PKC inhibitor
Go-6983 (133053-19-7) potent and pan-specific, ATP-competitive protein kinase C inhibitor. PKC isotype IC50s= 7, 7, 6, 10 and 60 nM for PKC α, β, γ...$40.00 – $130.00 Select options -
Cardiovascular
GW-501516 | PPAR delta agonist
GW-501516 (317318-70-0) is a potent and selective PPARδ (NR1C2) agonist, EC50=1.2 nM and 1000-fold selective over other PPAR subtypes.1 Induces ap...$55.00 – $190.00 Select options
