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Product Details

STF-31 | NAMPT inhibitor

STF-31 (724741-75-7) is an inhibitor of glucose transporter 1 (GLUT1; IC50 = 1 μM)1 and NAMPT3. Inhibition of glucose transporters to target It has been shown to kill renal cell carcinoma cells (the majority of which lack the von Hippel-Lindau suppressor gene) without toxicity to normal cells. The target of STF-31 anti-tumor activity has recently been questioned via use of large-scale cancer cell-line profiling.2 This profiling indicated that nicotinamide phosphoribosyltransferase (NAMPT) was in fact the target of STF-31. The inhibition of NAMPT by STF-31 was confirmed via biochemical assay against recombinant NAMPT. The ability of STF-31 to inhibit NAMPT had been previously displayed (IC50 = 19 nM).3

References/Citations
1) Chan et al. (2011), Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality; Sci. Transl. Med., 3 94ra70
2) Adams et al., (2014), NAMPT is the Cellular Target of STF-31-Like Small-Molecule Probes; ACS Chem. Biol., 9 2447
3) Dragovich et al. (2014), Fragment-based design of 3-aminopyridine-derived amides as potent inhibitors of human nicotinamide phosphribosyltransferase (NAMPT); Bioorg. Med. Chem. Lett., 24 954

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Catalog#  10-4570

$90.00
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CAS:
724741-75-7
Catalog Number:
10-4570
Activity:
NAMPT inhibitor
Chemical Name:
4-[[[[4-(1,1-Dimethylethyl)phenyl]sulfonyl]amino]methyl]-N-3-pyridinylbenzamide
Molecular Weight:
423.53
Molecular Formula:
C23H25N3O3S
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
White solid
Purity:
98% by HPLC
Storage Temperature:
-20°
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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