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Product Details

TMP-153 | ACAT inhibitor

TMP-153 (128831-46-9) is a potent and selective inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), IC50=5-10 nM. It inhibits cholesterol absorption and lowers plasma cholesterol in rats and hamsters.1,2 TMP-153 displays hypertoxic effect with prion-infected neuronal cell lines (ScGT1 and ScN2a cells) compared to their uninfected equivalents (GT1 and N2a).3 Inhibition of cholesterol ester biosynthesis with TMP-153 reduces HCV particle density and infectivity in hepatocytes.4

References/Citations
1) Sugiyama et al. (1995), TMP-153, a novel ACAT inhibitor, inhibits cholesterol absorption and lowers plasma cholesterol in rats and hamsters; Atherosclerosis, 113 71
2) Sugiyama et al. (1995), TMP-153, a novel ACAT inhibitor, lowers plasma cholesterol through its hepatic action in hamsters; Atherosclerosis., 118 145
3) Bate et al. (2008), Cholesterol esterification reduces the neurotoxicity of prions; Neuropharmacology, 54 1247
4) Read et al. (2014), Hepatitis C virus infection mediates cholesteyl ester synthesis to facilitate infectious particle production; J. Gen. Virol., 95 (Pt. 9) 1900

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Catalog#  10-2240

$36.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
128831-46-9
Catalog Number:
10-2240
Activity:
ACAT inhibitor
Chemical Name:
1-[4-(Chlorophenyl)-6,7-dimethylquinolin-3-yl]-3-(2,4-difluorophenyl)urea
Molecular Weight:
437.88
Molecular Formula:
C24H18ClF2N3O
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 10 mg/ml with warming)
Physical Properties:
solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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