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Product Details

Tranilast | NFkB inhibitor

Tranilast (53902-12-8) is an anti-allergy agent (inhibitor of mast cell degranulation) that has been shown to have potent immunomodulatory effects via inhibition of endotoxin induced: PGE2, IC50 = 1-20 μM; TXB2, IC50 = 10-50 μM; TGFβ1, IC50 = 100-200 μM; IL-8, IC50 = 100 μM .1,2,3 Tranilast also displays anti-angiogenic properties.4,5

References/Citations
1) Capper et al. (2000) Modulation of human monocyte activities by tranilast, SB252218, a compound demonstrating efficacy in restenosis; J. Pharmacol. Exp. Ther., 38 2673
2) Ward et al., (2002) Tranilast prevents activation of transforming growth factor-b system, leukocyte accumulation and neointimal growth in porcine coronary arteries after stenting; Arterioscler. Thromb. Vasc. Biol., 22 940
3) Chikaraishi et al. (2001) Tranilast inhibits linterleukin-1b-induced monocyte chemoattractant protein-1 expression in rat mesangial cells; Eur. J. Pharmacol., 427 151
4) Isaji et al. (1997) Tranilast inhibits the proliferation, chemotaxis and tube formation of human microvascular endothelial cells in vitro and angiogenesis in vivo; Br. J. Pharmacol., 122 1061
5) Koyama et al. (1999) Tranilast inhibits protein kinase C-dependent signaling pathway linked to angiogenic activities and gene expression of retinal microcapillary endothelial cells; Br. J. Pharmacol., 127 537

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Focus Biomolecules cell signaling reagent supplier, chemical structure of Tranilast | NFkB inhibitor | CAS 53902-12-8

Catalog#  10-2234

$40.00
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CAS:
53902-12-8
Catalog Number:
10-2234
Activity:
NFκB inhibitor
Alternate Names:
Rizaben
Chemical Name:
N-(3',4'-Dimethoxycinnamoyl)anthranilic acid
Molecular Weight:
327.34
Molecular Formula:
C18H17NO5
Solubility:
Soluble in DMSO (up to 30 mg/ml).
Physical Properties:
Pale yellow solid
Purity:
98% by TLC
NMR (Conforrms)
Storage Temperature:
RT
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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