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Cardamonin | NFkB inhibitor

CAS:
19309-14-9
Catalog Number:
10-2754
Activity:
NFκB inhibitor
Chemical Name:
(2E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-phenyl-2-propen-1-one
Molecular Weight:
270.29
Molecular Formula:
C16H14O4
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 5 mg/ml).
Physical Properties:
Yellow solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 weeks.
Shipping Code:
RT

Cardamonin (19309-14-9) inhibits NF-κB activation via inhibition of IκBα degradation and phosphorylation, IκB kinase activation and NF-κB nuclear translocation.1,2 Cardamonin displays anti-inflammatory activity in various models.3 Cell permeable.

References/Citations:

1) Lee et al. (2006), Blockade of nuclear factor-kappaB signaling pathway and anti-inflammatory activity of cardamonin, a chalcone analog from Alpinia conchigera; J. Pharmacol. Exp. Ther., 316 271
2) Israf et al. (2007), Cardamonin inhibits COX and iNOS expression via inhibition of p65NF-kappaB nuclear translocation and Ikappa-B phosphorylation in RAW 264.7 macrophage cells; Mol. Immunol., 44 673
3) Ahmad et al. (2006), Cardamonin, inhibits pro-inflammatory mediators in activated RAW 264.7 cells and whole blood; Eur. Pharmacol. Exp. Ther., 538 188

Cardamonin | NFkB inhibitor is also available in the Cellular Metabolism Library.
CAS:
19309-14-9
Catalog Number:
10-2754
Activity:
NFκB inhibitor
Chemical Name:
(2E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-phenyl-2-propen-1-one
Molecular Weight:
270.29
Molecular Formula:
C16H14O4
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 5 mg/ml).
Physical Properties:
Yellow solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 weeks.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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