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FQI1 | LSF inhibitor

CAS:
599151-35-6
Catalog Number:
10-1360
Activity:
LSF inhibitor
Chemical Name:
8-(2-Ethoxyphenyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]quinoline-6(5H)-one
Molecular Weight:
311.33
Molecular Formula:
C18H17NO4
Solubility:
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 20 mg/ml with warming)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

FQI1 (599151-35-6) is an inhibitor of transcription factor LSF specifically targeting its DNA binding and corresponding transcriptional activity (IC50=2.1 μM). Rapidly induces apoptosis in an aggressive hepatocellular carcinoma (HCC) cell line and dramatically inhibits tumor growth in a mouse xenograft model with no general tissue cytotoxicity.1,2 In human HCC cells, FQI1 induced mitotic arrest with an accompanying increase in cyclin B1.3 Blocks LSF-stimulated activation of DNA methyltransferase 1.4 Cell permeable.

References/Citations:

1) Grant et al. (2012), Antiproliferative small-molecule inhibitors of transcription factor LSF reveal oncogene addiction to LSF in hepatocellular carcinoma; Proc. Natl. Acad. Sci. USA, 109 4503
2) Santhekadur et al. (2012), The transcription factor LSF: a novel oncogene for hepatocellular carcinoma; Am. J. Cancer Res., 2 269
3) Raiasekaran et al. (2015), Small molecule inhibitors of Late SV40 Factor (LSF) abrogate hepatocellular carcinoma (HCC): Evaluation using an endogenous HCC model; Oncotarget 6 26266
4) Chin et al. (2016), Transcription factor LSF-DNMT1 complex dissociation by FQI1 leads to aberrant DNA methylation and gene expression; Oncotarget, 7 83627

FQI1 | LSF inhibitor is also available in the Cellular Metabolism Library.
CAS:
599151-35-6
Catalog Number:
10-1360
Activity:
LSF inhibitor
Chemical Name:
8-(2-Ethoxyphenyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]quinoline-6(5H)-one
Molecular Weight:
311.33
Molecular Formula:
C18H17NO4
Solubility:
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 20 mg/ml with warming)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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